Protein Alignment HDAC7 and hdac7a

DIOPT Version :10

• Sequence 1: XP_011536783.2
• Gene: HDAC7 / 51564
• HGNCID: 14067
• Length: 1035
• Species: Homo sapiens
• Sequence 2: XP_073795699.1
• Gene: hdac7a / 798603
• ZFINID: ZDB-GENE-150129-1
• Length: 986
• Species: Danio rerio
• Alignment Length: 1033
• Identity: 561/1033 - (54%)
• Similarity: 681/1033 - (65%)
• Gaps: 148/1033 - (14%)

Human    57 PGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEP----------PPEPTLL-------- 103
            ||:.: ||.|              |.|||||||:| .:.|          |..|.||
Zfish    31 PGSVW-SPEG--------------PVPMDLRVGER-LLRPGSGSDTAFLSPLHPQLLIGYNTQHC 79

Human   104 ---ALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVAS 165
               :.|:.||:..:.....||.|...                   :|:|:||.|||||::|||||
Zfish    80 SQYSQQQLQRIQQYNMEQHLQDQEQA-------------------KQQLQQLKHKDKSQQSAVAS 125

Human   166 SVVKQKLAEVILK--KQQAALERT-VHP-NSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 226
            ::||||||:||||  ||||.|||| .:| :||.:.||.|.| :.....:.:|||..|.:    ||
Zfish   126 ALVKQKLAQVILKKQKQQAVLERTNSNPLSSPSVAYRELVP-DPSAPLQPLLSSTKPAL----SD 185

Human   227 PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASG 291
            ..|..|||:..||||||:::|.||.|..||:||.|||||||:::.|..:.| ||||||||||.||
Zfish   186 GAEEPPLRRATSEPNLKVKHKLKKHLNTRKSPLTRKESAPPAVKHRTPDAL-DSSPSSSSTPVSG 249

Human   292 CSSPNDS---EHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRT 353
            |||||||   |:|.:....|.:...|||.||:.|::.|.:...|.||.|||||||.::.:.|
Zfish   250 CSSPNDSLPTENGASSSSSSLSHEAQRLLLQDGSLSHFTIQNSSSLPTITLGLPANSKVEGD--- 311

Human   354 HPTLGP----RGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSG-SHAPLLTVPGLGPL 413
               ||.    |.|:: |..:||.||.|:|...       :||:|:|:||| .|.|||.||||||:
Zfish   312 ---LGSLKLGRVPLV-SGSSPLLLPLGVEEPL-------MQPVLILEPSGLVHTPLLAVPGLGPV 365

Human   414 PFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPR-------------LEQLK 465
            |..|          |.||.|.|||||||||||.|      ||.:||.             |.:||
Zfish   366 PLQF----------SASGPHKPLSRTRSEPLPQS------PGRLQPHPHLLQQQQHSTHLLHRLK 414

Human   466 THVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQ---- 526
            .:..:.|...|.||||||||||| ||::::..||..    |..|  ||.|:.|::.....|
Zfish   415 QNTHLGKLMQKSSEKPRLRQIPS-EDMDSEEAGPAA----GDAH--LGRGRAESQREMENQEEQM 472

Human   527 --QHPQVL----LWEQQRLAGRLPRGSTG-DTVLLPLAQGG--HRPLSRAQSSPAAPASLSAPEP 582
              ||..:|    |||.|:...:|.|.:.. :|:.:|:..||  ||||||.|||||: .||:.||
Zfish   473 NLQHTLILHQSRLWETQKHLQQLRRQTAQMETLAVPMMLGGGQHRPLSRTQSSPAS-TSLTLPE- 535

Human   583 ASQARVLSSSETPARTLP-FTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQ 646
              :...|::...|.::.| |||||:|||.||||||:|||||.|||||||||||||||||||||.|
Zfish   536 --KTLPLTTPAEPPQSQPRFTTGLVYDSQMLKHQCTCGDNSSHPEHAGRIQSIWSRLQERGLRGQ 598

Human   647 CECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTI 711
            ||.:|||||:||||||||:||||||||||||:||||||.||||:|:|||||||||||||||.|||
Zfish   599 CESIRGRKATLEELQSVHTERHVLLYGTNPLNRLKLDNRKLAGILSQRMFVMLPCGGVGVDNDTI 663

Human   712 WNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQ 776
            |||:|:|.|:|.||||||:|||:||..|||||||||||||||||.|..||||||||||||.:|||
Zfish   664 WNEMHTSTASRMAAGSVTELAFRVAKGELKNGFAVVRPPGHHADPSNPMGFCFFNSVAIAAKQLQ 728

Human   777 QQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVN 841
            |:..||||||||||||||||||:.||.|||||||||||:|:||||||||...|||:|:|||||||
Zfish   729 QKLSASKILIVDWDVHHGNGTQEIFYNDPSVLYISLHRYDNGNFFPGSGGPAEVGSGAGEGFNVN 793

Human   842 VAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYM 906
            |||.|||:|||.|.|||||||.||||||:|||||:||||:|||||||||:|||||.|:|||||:|
Zfish   794 VAWTGGLEPPMADAEYLAAFRTVVMPIAQEFSPDVVLVSSGFDAAEGHPSPLGGYKVTAKCFGFM 858

Human   907 TQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVI 971
            |:|||.||||.||||||||||||||||||||||:||||.. :||.|....|.|:.:.:.||:.|:
Zfish   859 TRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLGLE-EPLPESTLLQTPSASGVLSLQRVL 922

Human   972 RVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILA-----EDRPSE 1024
            ::||:||..::.|..............|.||.:.|.|:||||||:|.     ||.|.|
Zfish   923 QIHSQYWSSLKPLMGTVGMSFLGAQRKDCEETDTVNAMASLSVGVLTNKTSLEDEPME 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC7	XP_011536783.2	PTZ00449	<49..370	CDD:185628	142/344 (41%)
		HDAC7	601..978	CDD:212532	297/376 (79%)
hdac7a	XP_073795699.1	None