DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC7 and hdac7a

DIOPT Version :9

Sequence 1:	XP_011536780.1	Gene:	HDAC7 / 51564	HGNCID:	14067	Length:	1035	Species:	Homo sapiens
Sequence 2:	XP_021325750.1	Gene:	hdac7a / 798603	ZFINID:	ZDB-GENE-150129-1	Length:	960	Species:	Danio rerio

Alignment Length:	1017	Identity:	549/1017 - (53%)
Similarity:	670/1017 - (65%)	Gaps:	143/1017 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    57 PGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEP----------PPEPTLL-------- 103
            ||:.: ||.|              |.|||||||:| .:.|          |..|.||
Zfish    31 PGSVW-SPEG--------------PVPMDLRVGER-LLRPGSGSDTAFLSPLHPQLLIGYNTQHC 79

Human   104 ---ALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVAS 165
               :.|:.||:..:.....||.|...                   :|:|:||.|||||::|||||
Zfish    80 SQYSQQQLQRIQQYNMEQHLQDQEQA-------------------KQQLQQLKHKDKSQQSAVAS 125

Human   166 SVVKQKLAEVILK--KQQAALERT-VHP-NSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSD 226
            ::||||||:||||  ||||.|||| .:| :||.:.||:...|:..|....:||...
Zfish   126 ALVKQKLAQVILKKQKQQAVLERTNSNPLSSPSVAYRSENTLKHTGLWSVLLSMLA--------- 181

Human   227 PPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASG 291
                |....:.||||||:::|.||.|..||:||.|||||||:::.|..:.| ||||||||||.||
Zfish   182 ----FCSCFSASEPNLKVKHKLKKHLNTRKSPLTRKESAPPAVKHRTPDAL-DSSPSSSSTPVSG 241

Human   292 CSSPNDS---EHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRT 353
            |||||||   |:|.:....|.:...|||.||:.|::.|.:...|.||.|||||||.::.:.| .:
Zfish   242 CSSPNDSLPTENGASSSSSSLSHEAQRLLLQDGSLSHFTIQNSSSLPTITLGLPANSKVEGD-LS 305

Human   354 HPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSG-SHAPLLTVPGLGPLPFHF 417
            ...|| |.|:: |..:||.||.|:|...       :||:|:|:||| .|.|||.||||||:|..|
Zfish   306 SLKLG-RVPLV-SGSSPLLLPLGVEEPL-------MQPVLILEPSGLVHTPLLAVPGLGPVPLQF 361

Human   418 AQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPR-------------LEQLKTHVQ 469
                      |.||.|.|||||||||||.|      ||.:||.             |.:||.:..
Zfish   362 ----------SASGPHKPLSRTRSEPLPQS------PGRLQPHPHLLQQQQHSTHLLHRLKQNTH 410

Human   470 VIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQ------QH 528
            :.|...|.||||||||||| ||::::..||..    |..|:  |.|:.|::.....|      ||
Zfish   411 LGKLMQKSSEKPRLRQIPS-EDMDSEEAGPAA----GDAHQ--GRGRAESQREMENQEEQMNLQH 468

Human   529 PQVL----LWEQQRLAGRLPRGSTG-DTVLLPLAQGG--HRPLSRAQSSPAAPASLSAPEPASQA 586
            ..:|    |||.|:...:|.|.:.. :|:.:|:..||  ||||||.|||||: .||:.||   :.
Zfish   469 TLILNQSRLWETQKHLQQLRRQTAQMETLAVPMMLGGGQHRPLSRTQSSPAS-TSLTLPE---KT 529

Human   587 RVLSSSETPARTLP-FTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECL 650
            ..|::...|.::.| |||||:|||.||||||:|||||.|||||||||||||||||||||.|||.:
Zfish   530 LPLATPAEPPQSQPRFTTGLVYDSQMLKHQCTCGDNSSHPEHAGRIQSIWSRLQERGLRGQCESI 594

Human   651 RGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNEL 715
            |||||:||||||||:||||||||||||:||||||.||||:|:|||||||||||||||.||||||:
Zfish   595 RGRKATLEELQSVHTERHVLLYGTNPLNRLKLDNRKLAGILSQRMFVMLPCGGVGVDNDTIWNEM 659

Human   716 HSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSK 780
            |:|.|:|.||||||:|||:||..|||||||||||||||||.|..||||||||||||.:||||:..
Zfish   660 HTSTASRMAAGSVTELAFRVAKGELKNGFAVVRPPGHHADPSNPMGFCFFNSVAIAAKQLQQKLS 724

Human   781 ASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWA 845
            ||||||||||||||||||:.||.|||||||||||:|:||||||||...|||:|:||||||||||.
Zfish   725 ASKILIVDWDVHHGNGTQEIFYNDPSVLYISLHRYDNGNFFPGSGGPAEVGSGAGEGFNVNVAWT 789

Human   846 GGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQL 910
            |||:|||.|.|||||||.||||||:|||||:||||:|||||||||:|||||.|:|||||:||:||
Zfish   790 GGLEPPMADAEYLAAFRTVVMPIAQEFSPDVVLVSSGFDAAEGHPSPLGGYKVTAKCFGFMTRQL 854

Human   911 MNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHS 975
            |.||||.||||||||||||||||||||||:||||.. :||.|....|.|:.:.:.||:.|:::||
Zfish   855 MTLAGGRVVLALEGGHDLTAICDASEACVSALLGLE-EPLPESTLLQTPSASGVLSLQRVLQIHS 918

Human   976 KYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGIL 1017
            :||..::.|..............|.||.:.|.|:||||||:|
Zfish   919 QYWSSLKPLMGTVGMSFLGAQRKDCEETDTVNAMASLSVGVL 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC7	XP_011536780.1	HDAC7	601..978	CDD:212532	297/376 (79%)
hdac7a	XP_021325750.1	HDAC_classIIa	545..921	CDD:212544	297/376 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	552	1.000	Domainoid score	I2135
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9124
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	9	9.420