DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDGFRA and drpr

DIOPT Version :9

Sequence 1:	NP_001334757.1	Gene:	PDGFRA / 5156	HGNCID:	8803	Length:	1114	Species:	Homo sapiens
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	55/259 - (21%)
Similarity:	87/259 - (33%)	Gaps:	98/259 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   870 HDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFY-NK 933
            ||:|         |..| .|...|||                        |..||..::... |.
  Fly   840 HDTN---------PPSW-PPNHNFDN------------------------PVYGMQAETRLLPNN 870

Human   934 IKSGYRMAKPD-------------HATSEV--------YEIMVKCWNSEPEKRPSFYHLSEIVEN 977
            ::|  :|...|             :|:..|        ::::.|..|:: ...|..|:.|...|:
  Fly   871 MRS--KMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNHDLLTKNLNAD-RTNPIVYNESLKEEH 932

Human   978 LL-----PGQYK---KSYEKI--------HLDFLK---SDHPAVARMRVDSDNAYIGVTYKNEE- 1022
            :.     ...||   |.|.||        |||:.:   |..|...||    ::|.:.:....|:
  Fly   933 VYDEIKHKEGYKDPVKIYSKILFPEDEYDHLDYSRPSTSQKPHYHRM----NDAMLNINQDEEKP 993

Human  1023 DKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIK 1086
            ..:|:....|::           |||..:|.|:.|.....|.:....|..|.    |||..|:|
  Fly   994 SNVKNMTVLLNK-----------PLPPTEPEPQHECFDNTNTNLDNVSTASP----SSSPKFLK 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
PDGFRA	NP_001334757.1	None
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900