Protein Alignment PDGFRA and tor

DIOPT Version :9

• Sequence 1: NP_001334757.1
• Gene: PDGFRA / 5156
• HGNCID: 8803
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 223/905 - (24%)
• Similarity: 356/905 - (39%)
• Gaps: 259/905 - (28%)

Human   291 VPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNL- 354
            :|.::...|..:....:...|.|...|          |..|.:...:|:   :|  |::.||||
  Fly   136 LPGLESNSTHNITALAMHGDGSYSLIA----------KDQTFATLIRGY---QP--SKMGAVNLL 185

Human   355 ------HEVKHFVVEVRAYPPPR-------ISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKL 406
                  .::.|...|:...|...       :|:..|::.:.|.|           |:::|.:.||
  Fly   186 RFVPQPDDLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDEPL-----------EVQFRDRKKL 239

Human   407 IRAKEEDSGHYTIVAQNEDAVKSY-----TFELLTQVPS----------SILD-------LVDDH 449
            .|        :|:  .|.:..|.|     |..::.::.|          |.||       |...|
  Fly   240 YR--------HTV--DNLEFDKQYHVGVRTVNIMNRLESDLQWLPIAVPSCLDWYPYNYTLCPPH 294

Human   450 HGSTGGQTVR-----------CTAEGTPLPDIEWMICKDIKKCNNETSWTILANN----VSNIIT 499
            .......|.:           ..|....|||...:...|:.|...|.::|:..|.    |..|..
  Fly   295 KPENLTVTQKQYLPNILALNITWARPRYLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITV 359

Human   500 -----EIH----SRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAA 555
                 |:|    |.....|.| :|..||.         :.:|.:|...:|
  Fly   360 LGSHFEVHLVAQSAGGKNVSG-LTLDKVH---------RGVLLSEGNMVK--------------- 399

Human   556 VLVLLVIVIISLIVLV--VIWKQKPRYEIRWRVIESISPDGHEYIYVDPM-------------QL 605
             |||.:||.|..|:::  :.:.::.|.|::...:::......|: ::..|             .|
  Fly   400 -LVLFIIVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEF-HLSLMDSSGLLVTLSANESL 462

Human   606 PYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL 670
            ......|.....::|..|||.||||.|..|.       ....:||||:||......:..|...|:
  Fly   463 EVMDELEVEPHSVLLQDVLGEGAFGLVRRGV-------YKKRQVAVKLLKDEPNDEDVYAFKCEI 520

Human   671 KIMTHLGPHLNIVNLLGACTK-SGPIYIITEYCFYGDLVNYLHK--------------------- 713
            :::..:|.|.|||.::|..|: |..:.::.|||..|.|.|:|.:
  Fly   521 QMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNV 585

Human   714 -----NR--------------DSFLSHHPEKPKKE------LDIFGL----NPADESTRSYVILS 749
                 ||              :|.||...|:.:.:      .:.:.|    |.||  .:.|.:..
  Fly   586 DNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAAD--NKGYGLED 648

Human   750 FENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSE- 813
            .||.|.....|.|:..:..|..:.|...|    :.|..|..:..||:...:.|..:.|...:::
  Fly   649 IENIGGSYIPKTAEAPKDRPKRKLKPQPK----KDSKQDFKSDNKKRIFENKEYFDCLDSSDTKP 709

Human   814 --GLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY-V 875
              .|...|||....|||.||||||....|||||||||||::..:.:||.||||:||:.|::.| .
  Fly   710 RIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRK 774

Human   876 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRM 940
            |.||..||:||:|.||:...:||:.|||||:|:||:||.:|||.|||.:. .|.....::.|:||
  Fly   775 SGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRM 838

Human   941 AKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE------IVENLLPGQYKKSYEKIHLDFLKSDH 999
            .:|:..|.|::.:|..||:|.|..||:|..|..      :..|.:|.:.|:
  Fly   839 KRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQ-------------- 889

Human  1000 PAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDL 1059
                             .....|.|||..: ||:.:              ::.||.||:|
  Fly   890 -----------------LQAATESKLKSCD-GLNSK--------------VEQVPCEEEL 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDGFRA	NP_001334757.1	None
tor	NP_476762.1	FN3	199..261	CDD:214495	16/82 (20%)
		STYKc	475..873	CDD:214568	136/411 (33%)
		PTKc	479..873	CDD:270623	135/407 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010