Protein Alignment RAB14 and Rab7

DIOPT Version :10

• Sequence 1: NP_057406.2
• Gene: RAB14 / 51552
• HGNCID: 16524
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_524472.1
• Gene: Rab7 / 42841
• FlyBaseID: FBgn0015795
• Length: 207
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 74/214 - (34%)
• Similarity: 117/214 - (54%)
• Gaps: 23/214 - (10%)

Human    11 IFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRA 75
            :.|.||:||..|||:.|::|:..|:|......|||.:|.|:.:.|:.:.:.:|||||||||||::
  Fly     8 LLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQS 72

Human    76 VTRSYYRGAAGALMVYDITRRSTYNHLSSW----LTDARNLTNPNTVIILIGNKADLEAQRDVTY 136
            :..::||||...::|||:|..:::.:|.||    |..|......:...:::|||.||: .|.|:.
  Fly    73 LGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLD-NRQVST 136

Human   137 EEAKQFAE-ENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGG 200
            ..|:|:.: :|.:.:.|.|||.|.|||.||        |.|...:|:|.|....:...|.
  Fly   137 RRAQQWCQSKNDIPYYETSAKEGINVEMAF--------QVIAKNALELEAEAEVINDFPD----- 188

Human   201 RLTSEPQPQREG----CGC 215
            ::|...|..|.|    |.|
  Fly   189 QITLGSQNNRPGNPDNCQC 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB14	NP_057406.2	Rab14	10..175	CDD:133322	62/168 (37%)
		Switch 1. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	42..47		3/4 (75%)
		Switch 2. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	68..77		6/8 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..215		6/30 (20%)
Rab7	NP_524472.1	Rab7	9..179	CDD:206655	66/178 (37%)