Protein Alignment RAB14 and Rab8

DIOPT Version :10

• Sequence 1: NP_057406.2
• Gene: RAB14 / 51552
• HGNCID: 16524
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Alignment Length: 187
• Identity: 82/187 - (43%)
• Similarity: 118/187 - (63%)
• Gaps: 0/187 - (0%)

Human     8 YSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQER 72
            |.|:||.::|||.||||:|:|.:|:|..|......|||::|..|.||:..:||||||||||||||
  Fly     5 YDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTAGQER 69

Human    73 FRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYE 137
            ||.:|.:|||||.|.::|||||:..::.::.:|:.:.....:.:...:|:|||.:|..:|.|:.|
  Fly    70 FRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQVSKE 134

Human   138 EAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKP 194
            ..:|.|.|.|:.|:|.|||...|||:|||..|..|....:......|..:.|.|.||
  Fly   135 RGEQLAIEYGIKFMETSAKASINVEEAFLTLASDIKAKTEKRMEANNPPKGGHQLKP 191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB14	NP_057406.2	Rab14	10..175	CDD:133322	76/164 (46%)
		Switch 1. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	42..47		3/4 (75%)
		Switch 2. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	68..77		7/8 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..215		4/7 (57%)
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	76/165 (46%)