Protein Alignment RAB14 and Rab3

DIOPT Version :10

• Sequence 1: NP_057406.2
• Gene: RAB14 / 51552
• HGNCID: 16524
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Alignment Length: 213
• Identity: 77/213 - (36%)
• Similarity: 123/213 - (57%)
• Gaps: 7/213 - (3%)

Human     4 APYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTA 68
            |..|:.|:||.:|||:..|||:..|.::.:..|.:....|:|::|..:.:....:::||||||||
  Fly    14 ADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTA 78

Human    69 GQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRD 133
            ||||:|.:|.:|||||.|.:::||:|...::|.:..|:|..:..:..|..:||:|||.|:|.||.
  Fly    79 GQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRV 143

Human   134 VTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQ 198
            :::|..:|.|::.|:.|.|.|||...||:..|......|...:.: |||.:....|     ...:
  Fly   144 ISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSE-SLDADPTLVG-----GGQK 202

Human   199 GGRLTSEPQ-PQREGCGC 215
            |.|||.:|| .....|.|
  Fly   203 GQRLTDQPQGTPNANCNC 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB14	NP_057406.2	Rab14	10..175	CDD:133322	63/164 (38%)
		Switch 1. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	42..47		2/4 (50%)
		Switch 2. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	68..77		6/8 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..215		8/27 (30%)
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	62/163 (38%)