Protein Alignment RAB14 and Rab21

DIOPT Version :10

• Sequence 1: NP_057406.2
• Gene: RAB14 / 51552
• HGNCID: 16524
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_001036321.2
• Gene: Rab21 / 3355163
• FlyBaseID: FBgn0039966
• Length: 222
• Species: Drosophila melanogaster
• Alignment Length: 219
• Identity: 81/219 - (36%)
• Similarity: 121/219 - (55%)
• Gaps: 27/219 - (12%)

Human    12 FKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEV-SGQKIKLQIWDTAGQERFRA 75
            ||.:::|:..|||:.|:.::.|.:|.|....|:...|.:|.:.: .|::.:|.||||||||||.|
  Fly    14 FKAVLLGEGCVGKTSLVLRYMEDRFNAQHLSTLQASFVSRKMSLEDGRRAQLNIWDTAGQERFHA 78

Human    76 VTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAK 140
            :...||||:.|||:|||||.|.::..:.||:.:.|.:......:|::|||.|||.||.||::||.
  Fly    79 LGPIYYRGSDGALLVYDITDRDSFQKVKSWVRELRQMRGTEIALIIVGNKTDLEEQRAVTHDEAL 143

Human   141 QFAEENGLLFLEASAKTGENVEDAF-------LE--------AAKKIYQNIQDGSLDLNAAESGV 190
            |:|...|..::|.|||..|.|.:.|       ||        |:....||....:|: |:.:|
  Fly   144 QYARTVGAQYVETSAKENEGVAELFELLTQLMLEQLSQRQPDASPLRLQNPDTDNLN-NSDDS-- 205

Human   191 QHKPSAPQGGRLTSEPQPQREGCG 214
                .||..|    :|..||..||
  Fly   206 ----EAPDPG----DPAGQRSCCG 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB14	NP_057406.2	Rab14	10..175	CDD:133322	68/178 (38%)
		Switch 1. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	42..47		1/4 (25%)
		Switch 2. /evidence=ECO:0000269|PubMed:26032412, ECO:0007744|PDB:4D0G	68..77		7/8 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..215		9/27 (33%)
Rab21	NP_001036321.2	Rab21	14..176	CDD:133323	65/161 (40%)