Protein Alignment VPS54 and vps54

DIOPT Version :10

• Sequence 1: NP_057600.2
• Gene: VPS54 / 51542
• HGNCID: 18652
• Length: 977
• Species: Homo sapiens
• Sequence 2: NP_001124248.1
• Gene: vps54 / 562169
• ZFINID: ZDB-GENE-081022-176
• Length: 998
• Species: Danio rerio
• Alignment Length: 1004
• Identity: 671/1004 - (66%)
• Similarity: 817/1004 - (81%)
• Gaps: 33/1004 - (3%)

Human     1 MASSHSSSPVPQ-----GSSSDVFFKIEVDP---SKHIRPVPSLPDVCPKEPTGDSHSLYVAPSL 57
            |:|:..|||:||     |.:||.||:...:|   .||.|...|||||||||||||...|...||:
Zfish     1 MSSNQGSSPIPQCSGAGGGTSDGFFRKHREPPLAPKHYRTARSLPDVCPKEPTGDGGGLCEGPSV 65

Human    58 VTDQHRWTVYHSKVNLPAALNDPRLAKRESDFFTKTWGLDFVDTEVIPSFYLPQISKEHFTVYQQ 122
            |.||||||||:||||||||||||||||||||||||||||||.:|||:||||||.|::|||:.|.|
Zfish    66 VADQHRWTVYNSKVNLPAALNDPRLAKRESDFFTKTWGLDFSETEVMPSFYLPNITREHFSSYLQ 130

Human   123 EISQREKIHERCKNICPPKDTFE-RTLLHTHDKSRTDLEQVPKIFMKPDFALDDSLTFNSVLPWS 186
            :.:||||||||||||||.||... .::.:.|:|:|.:|||||||||||:|.|:|..|||:|||||
Zfish   131 DTAQREKIHERCKNICPSKDDLSVSSITNNHEKARAELEQVPKIFMKPEFVLNDPATFNAVLPWS 195

Human   187 HFNTAGGKGNRDAASSKLLQEKLSHYLDIVEVNIAHQISLRSEAFFHAMTSQHELQDYLRKTSQA 251
            ||:.||||.:||.|||:|||||||||||:|||:||.|||||||||||||:|||||||.||:|:.|
Zfish   196 HFSVAGGKNSRDVASSRLLQEKLSHYLDVVEVSIARQISLRSEAFFHAMSSQHELQDQLRETADA 260

Human   252 VKMLRDKIAQIDKVMCEGSLHILRLALTRNNCVKVYNKLKLMATVHQTQPTVQVLLSTSEFVGAL 316
            |..||.:.|.||:|||.|.|.:||.|||||||:|::|||||||.|||||||||:|||||||||||
Zfish   261 VAKLRARTAAIDRVMCRGPLRVLRDALTRNNCIKLHNKLKLMAAVHQTQPTVQLLLSTSEFVGAL 325

Human   317 DLIATTQEVLQQELQGIHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEDDCQVLEEER 381
            :|||||:||||||||||||||||||||||:|:||||||:|:||||:.|||:|..|:|.||||::|
Zfish   326 ELIATTKEVLQQELQGIHSFRHLGSQLCEMERLIDKMMVADFSTYAQSDLSRTFEEDGQVLEKDR 390

Human   382 LISLVFGLLKQRKLNFLEIYGEKMVITAKNIIKQCVINKVSQTEEIDTDVVVKLADQMRMLNFPQ 446
            |.|||||||:||||:||:||.|:|:..|||:::|||:..:||..|:|.| .|::.:|||::.|..
Zfish   391 LQSLVFGLLRQRKLDFLDIYSEEMIRAAKNVVRQCVVKSLSQVNEVDAD-TVRIHEQMRLMAFHH 454

Human   447 WFDLLKDIFSKFTIFLQRVKATLNIIHSVVLSVLDKNQRTREL--------------EEISQQKN 497
            |||||.|||..|.:||:|:||||.:|.:|||.|||.:||:|..              |:..::..
Zfish   455 WFDLLLDIFEHFILFLKRIKATLGVIRNVVLEVLDSSQRSRLADATTATSHPDGRVNEDEEEESG 519

Human   498 AAKDNSLDTEVAYLIHEGMFISDAFGEGELTPIAVDTTSQRNA-SPNSEPCSSDSVSEPECTTDS 561
            ....:..:.|:|||.|||:|||||..:.|...:.....:|..| :|.::.|.|||.|   .||:|
Zfish   520 GPALHPGEAELAYLTHEGLFISDALNDAEQRSVTTAAQTQTRAQTPRADACGSDSAS---ATTES 581

Human   562 SSSKEHTS--SSAIPGGVDIMVSEDMKLTDSELGKLANNIQELLYSASDICHDRAVKFLMSRAKD 624
            |||:||.|  :|.:|.|...:  ||:..:|.|||::|||:|||||:|||:.|||.||.||:||||
Zfish   582 SSSREHNSNTTSCLPVGAAAL--EDVMPSDLELGRVANNVQELLYAASDVSHDRCVKVLMTRAKD 644

Human   625 GFLEKLNSMEFITLSRLMETFILDTEQICGRKSTSLLGALQSQAIKFVNRFHEERKTKLSLLLDN 689
            |.||:|:|.||:.||:.:|:|:.|||::|||:|.||.|||||||.:||.||||||||||||||||
Zfish   645 GSLERLSSSEFVCLSQAVESFVKDTEELCGRRSVSLRGALQSQANRFVQRFHEERKTKLSLLLDN 709

Human   690 ERWKQADVPAEFQDLVDSLSDGKIALPEKK-SGATEERKPAEVLIVEGQQYAVVGTVLLLIRIIL 753
            ||||||:|||||||||||::||:|:|||:| |..:|:|||.|.|.|:||:||||||||||||:.|
Zfish   710 ERWKQAEVPAEFQDLVDSIADGRISLPERKHSSGSEDRKPTEFLCVDGQKYAVVGTVLLLIRMFL 774

Human   754 EYCQCVDNIPSVTTDMLTRLSDLLKYFNSRSCQLVLGAGALQVVGLKTITTKNLALSSRCLQLIV 818
            ||||||::|||:|||::|||:||||:||||.|||||||||||.||||||||:||||:||||||:|
Zfish   775 EYCQCVNDIPSITTDIITRLADLLKHFNSRCCQLVLGAGALQAVGLKTITTRNLALASRCLQLVV 839

Human   819 HYIPVIRAHFEARLPPKQYSMLRHFDHITKDYHDHIAEISAKLVAIMDSLFDKLLSKYEVKAPVP 883
            |||||||||||.||.|||||:|||||||||||:|||||:||||||||||:|:|.:||||||||:|
Zfish   840 HYIPVIRAHFETRLQPKQYSILRHFDHITKDYNDHIAEVSAKLVAIMDSMFEKAVSKYEVKAPMP 904

Human   884 SACFRNICKQMTKMHEAIFDLLPEEQTQMLFLRINASYKLHLKKQLSHLNVINDGGPQNGLVTAD 948
            |||.||:||||.||||||.:|||||||||||||||||:|||||:|||.|.|.||||||||||..|
Zfish   905 SACLRNVCKQMLKMHEAIHELLPEEQTQMLFLRINASFKLHLKRQLSRLGVSNDGGPQNGLVMVD 969

Human   949 VAFYTGNLQALKGLKDLDLNMAEIWEQKR 977
            ||||:.|:|.|:.|:.|||||.|||||||
Zfish   970 VAFYSENVQGLRSLERLDLNMPEIWEQKR 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS54	NP_057600.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..575		18/42 (43%)
		Vps54	737..865	CDD:462318	107/127 (84%)
vps54	NP_001124248.1	Vps54	758..886	CDD:462318	107/127 (84%)