Protein Alignment PDE9A and Pde11

DIOPT Version :9

• Sequence 1: NP_002597.1
• Gene: PDE9A / 5152
• HGNCID: 8795
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 146/543 - (26%)
• Similarity: 237/543 - (43%)
• Gaps: 83/543 - (15%)

Human    69 ANSERTPYKVR-PVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRP 132
            |.|..:||:.| |:.|     |:.....|: |::...|               .|:|..:.:...
  Fly   654 ATSRTSPYESRFPINI-----GITGHVATT-GETVNVP---------------NAYEDDRFDASV 697

Human   133 REPQGCYQEGQRIPPEREEL---IQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLK 194
            .| ..|::       .|..|   |::.|.|:........|.|||.. ..|....:|......|:.
  Fly   698 DE-NSCFK-------HRSILCMAIKNSLGQIIGVIQLINKFNELDF-TKNDENFVEAFAIFCGMG 753

Human   195 VVEIEKCKSDIKKMR------EELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETI 253
            :......:..|..|.      |.|:..:|.|        :|...:|. |..||:...:.|.....
  Fly   754 IHNTHMYEKAIVAMAKQSVTLEVLSYHASAT--------MDEAHRLR-RLRVPSAVHFRLHDFKF 809

Human   254 EALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCF 318
            :       |:...:.:.:.:|| .|:.||..|..|.|:...|.|||..|..||||..:||:||.|
  Fly   810 D-------DIHFEDDDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAF 866

Human   319 CVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLEN 383
            .|||||::::......:.|.:.:.|.|:...:||||||.|.||::||.|.:.||..|: .|.:|:
  Fly   867 NVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEH 930

Human   384 HHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKME--NFDYSN 446
            ||......||..|...|.:|:..|.:.::.:.:...||:||:|.:.:....|.|.:.  ...:..
  Fly   931 HHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVA 995

Human   447 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAP--FMDRDKVTK 509
            ||...||:.:.:..||:|...:|.|:.:...|.:..|:|.|.|.||.| |.:.|  .|:|:|..:
  Fly   996 EEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDE 1059

Human   510 -ATAQIGFIKFVLIPMFETVT----KLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDS 569
             ...|:.||..:.:|::|...    ||.|:||.:.     ::|..:.:|.   |.:|       :
  Fly  1060 LPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVR-----DNRGHWIDLA---DVVK-------T 1109

Human   570 LTSGATEKSRERSRDVKNSEGDC 592
            .||...|...|:.:....|.|||
  Fly  1110 KTSQDQEPEEEQQQQNVISNGDC 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE9A	NP_002597.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..141		8/53 (15%)
		PDEase_I	311..539	CDD:278654	77/236 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..593		8/29 (28%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	27/137 (20%)
		PDEase_I	859..1094	CDD:278654	77/236 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820