DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DTL and l(2)dtl

DIOPT Version :9

Sequence 1:	NP_057532.4	Gene:	DTL / 51514	HGNCID:	30288	Length:	730	Species:	Homo sapiens
Sequence 2:	NP_524871.1	Gene:	l(2)dtl / 46326	FlyBaseID:	FBgn0013548	Length:	769	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	228/758 - (30%)
Similarity:	336/758 - (44%)	Gaps:	145/758 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    49 PVPP-FGCTFSSAPNMEHVLAVANEEGFVRLYNT-------ESQSF-RKKCFKEWMAHWNAVFDL 104
            |.|| |...|::.....|:||:|||:|.:.|.:|       |.||. ..:|      |:||||||
  Fly    49 PEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQC------HFNAVFDL 107

Human   105 AWVPGELKLVTAAGDQTAKFWDVKAGELIG--TCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMV 167
            .|.||:::.|:|:||.||:.|:|....:.|  :..||..|:||.||.:.:.|||.||||||.|::
  Fly   108 EWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILI 172

Human   168 WDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVS 232
            ||.|.|.......:|:....:.:|....||...:|::.............|:|.:.|||.:||:|
  Fly   173 WDIRANLNMDLTSRVDNCIYSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLIS 237

Human   233 AGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYM 297
            .||.||:|||||||:|||||::||:......|.||||.: |:::||:|::|:.|:|||.|:.||.
  Fly   238 CGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPYAGSSTFR-GFTNLIVDASGTRLYANCMDNTIYC 301

Human   298 FNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQE 362
            :|:......|:|.:.|..|||||:||.||||.::|:||||||.||||.:....:|...|.||:.|
  Fly   302 YNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHAEEPLVALAGHTVE 366

Human   363 VTSVCWCPSDFTKIATCSDDNTLKIWRLN---RGLEEKPGGDKLSTVGWAS-------------- 410
            ||.|.|..|....|.|||||...||||:.   .||.|....:|..  |.||
  Fly   367 VTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAERAEKYR--GTASYVREFGKKAFGPSS 429

Human   411 --------------------QKKKESRPGLVTVTSS------------QSTPA-KAPRAKCNPSN 442
                                ..:.|..||.|..|::            |.|.| :.|:.:..|..
  Fly   430 GNHKYNLRDLESTPRSLKRLMDQNERTPGSVEKTTTKRSFLEMLGVAGQETEATEQPQKRAKPLE 494

Human   443 S------SPSS--AACAPSCAGDLPLPSNTPTFSIK-TSPAKARSPINRRGSVSSVSPKPPSSFK 498
            |      .|||  .||.......:.....:|:...| .|.|:..||:::..|..|.||     ..
  Fly   495 SRGRRLFGPSSQETACRHIQLQSINEEDASPSKRQKENSAAEDVSPLHKLLSTPSHSP-----LS 554

Human   499 MSIRNWVTRTPSSS--------PPITPPASETKIMSPRKALIPVSQKSSQAE--ACSESRNRVKR 553
            .::.:..|..|::|        ..:.||.....|.||...| |......:|.  .....:.:.|.
  Fly   555 ENVNHVYTSPPTTSAAAAAVAADALNPPPISAAIYSPTSNL-PNYVLDGEAPHLGIMSPKRKAKE 618

Human   554 RLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGTSI 618
            ::|  .|.:::::.:.|......|..::             .|:...|.|.   |.:::....|.
  Fly   619 KVD--WLTNIRKQKLMSGRAHVTLSEKI-------------SEEQQADVLA---SPRLQSLRQSE 665

Human   619 SEPPSPISP-----YASESCGTLPLPLRPCGEGSEMVGKENSSPENKNWLLAMAAKRKAENP--- 675
            ..|....||     :.....||      |.|..|.  ....|.|:...     :::|.:|..
  Fly   666 CSPRIHASPRRRISHTDGGGGT------PAGSSSH--SHSQSQPKTPT-----SSRRNSETTLLR 717

Human   676 ------SPRSPSSQTPNSRRQSGKKLPSPVTI-----TPSSMR 707
                  |...|:.:|..:........|.|..:     ||.|||
  Fly   718 FFSIQRSSSVPAEETTTTNAAPSSSDPHPPAVTAPAATPLSMR 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DTL	NP_057532.4	WD 1	47..89		17/48 (35%)
		WD40	55..389	CDD:238121	146/343 (43%)
		WD40 repeat	55..96	CDD:293791	14/48 (29%)
		WD 2	96..135		19/40 (48%)
		WD40 repeat	101..137	CDD:293791	16/37 (43%)
		WD 3	138..178		21/39 (54%)
		WD40 repeat	144..197	CDD:293791	20/52 (38%)
		DDB1-binding motif	168..171		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..210		4/21 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	197..203		1/5 (20%)
		WD 4	214..253		23/38 (61%)
		WD40 repeat	219..312	CDD:293791	45/92 (49%)
		DDB1-binding motif	243..246		2/2 (100%)
		WD40 repeat	264..304	CDD:293791	18/39 (46%)
		WD 5	267..308		16/40 (40%)
		WD 6	313..354		24/40 (60%)
		WD40 repeat	320..356	CDD:293791	19/35 (54%)
		WD 7	358..398		21/42 (50%)
		WD40 repeat	363..388	CDD:293791	12/24 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		14/90 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..498		10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..631		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..703		11/72 (15%)
l(2)dtl	NP_524871.1	WD40	27..442	CDD:225201	159/401 (40%)
		WD40	52..393	CDD:295369	148/347 (43%)
		WD40 repeat	53..99	CDD:293791	14/45 (31%)
		WD40 repeat	105..143	CDD:293791	15/37 (41%)
		WD40 repeat	148..212	CDD:293791	23/63 (37%)
		WD40 repeat	220..263	CDD:293791	26/42 (62%)
		WD40 repeat	270..316	CDD:293791	19/46 (41%)
		WD40 repeat	324..361	CDD:293791	19/36 (53%)
		WD40 repeat	367..392	CDD:293791	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143696
Domainoid	1	1.000	62	1.000	Domainoid score	I10407
eggNOG	1	0.900	-	-		E1_KOG0321
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4390
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1288134at2759
OrthoFinder	1	1.000	-	-		FOG0005579
OrthoInspector	1	1.000	-	-		oto88504
orthoMCL	1	0.900	-	-		OOG6_104235
Panther	1	1.100	-	-	LDO	PTHR22852
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4627
SonicParanoid	1	1.000	-	-		X4553
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.690