DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DTL and dtl

DIOPT Version :9

Sequence 1:	NP_057532.4	Gene:	DTL / 51514	HGNCID:	30288	Length:	730	Species:	Homo sapiens
Sequence 2:	NP_775348.1	Gene:	dtl / 192314	ZFINID:	ZDB-GENE-020419-34	Length:	647	Species:	Danio rerio

Alignment Length:	730	Identity:	354/730 - (48%)
Similarity:	445/730 - (60%)	Gaps:	125/730 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    16 RNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYN 80
            |||....:||.|||..|:|:..|||.|||.:...|||||||||||...::.||||||||||.::|
Zfish    17 RNGEQRLFPLSSLLDCYECARRDEHISYGASAAAVPPFGCTFSSAHGQQNCLAVANEEGFVTIFN 81

Human    81 T-ESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLK 144
            | |.||   ...|||.||.|||||:|||||...||||:|||||:.|||..|:|:||.||||||||
Zfish    82 TGEKQS---SVLKEWQAHDNAVFDIAWVPGTNCLVTASGDQTARLWDVITGDLLGTFKGHQCSLK 143

Human   145 SVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGL 209
            ||||.|.|||||.|||||||||:|||||:|||||||||.||||||...::.||...|:    :|:
Zfish   144 SVAFYKQEKAVFSTGGRDGNIMIWDTRCSKKDGFYRQVKQISGAHMKPERFTPQTKKR----RGM 204

Human   210 APSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGY 274
            ||.||.||.||||||.||..|:|:||||||||:||||:|||||.|.|:..:::.||||.||||||
Zfish   205 APPVDSQQGVTVVLFCDETKLISSGAVDGIIKMWDLRRNYTAYHQNPLPLQAYPYPGSCTRKLGY 269

Human   275 SSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDE 339
            |.|.||.|||.||:|||||||||||::||||:|:|:|:||.:|:|||||::|||||||.|||||.
Zfish   270 SGLSLDYTGSRLFSNCTDDNIYMFNISGLKTTPIAVFSGHSSSSFYVKSTVSPDDQFLASGSSDH 334

Human   340 AAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLS 404
            ..|||::|.|.|.|.:|.|||||||||.|||:||||||:||||||::||||||    ||.|:. |
Zfish   335 NVYIWRISDPKQAPMMLQGHSQEVTSVAWCPTDFTKIASCSDDNTVRIWRLNR----KPEGEN-S 394

Human   405 T------VGWASQKKKESR--PGLVTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLP 461
            |      |||..:|.:...  ||  ..:..:.||:|.|.:..:.|.:||..|.|||:.|. ||||
Zfish   395 TIQDGNLVGWTIRKVQSPNRTPG--HHSPVELTPSKNPGSVRSVSLASPQPATCAPTGAA-LPLP 456

Human   462 SNTPTFSIKTSPAKARSPINRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMS 526
            |||.:    ..|||.            .|||.||    |::.|::|  ||..|:
Zfish   457 SNTSS----APPAKL------------TSPKMPS----SLQQWISR--SSKSPV----------- 488

Human   527 PRKALIPVSQKSSQAEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCL 591
             ||||.||.|..|       ...||||||::.  :|......:..:.|:||...|:.....:..|
Zfish   489 -RKALTPVLQGLS-------FERRVKRRLETG--DSASSGLGEEIDGVSELYPNVKRSRSSVSTL 543

Human   592 AGNQEDLSKDSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSS 656
            .      .:||.| .:|.|.:|:                              :|:|..||||||
Zfish   544 K------KEDSFG-LESEKRQGS------------------------------DGAEASGKENSS 571

Human   657 PENKNWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITP-----------------S 704
            |...:||..::.|.|. :..|:||||   .|.:|..:.|.||..::|                 .
Zfish   572 PRRTDWLSVISQKFKG-SAQPKSPSS---GSSQQDTRTLESPAAVSPRPMKVFSPPTNKKASPSK 632

Human   705 SMRKICTYFHRKSQE 719
            .|:||.:||.:::|:
Zfish   633 PMKKISSYFMKRTQD 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DTL	NP_057532.4	WD 1	47..89		26/42 (62%)
		WD40	55..389	CDD:238121	228/334 (68%)
		WD40 repeat	55..96	CDD:293791	24/41 (59%)
		WD 2	96..135		26/38 (68%)
		WD40 repeat	101..137	CDD:293791	24/35 (69%)
		WD 3	138..178		34/39 (87%)
		WD40 repeat	144..197	CDD:293791	40/52 (77%)
		DDB1-binding motif	168..171		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..210		6/21 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	197..203		2/5 (40%)
		WD 4	214..253		29/38 (76%)
		WD40 repeat	219..312	CDD:293791	65/92 (71%)
		DDB1-binding motif	243..246		2/2 (100%)
		WD40 repeat	264..304	CDD:293791	31/39 (79%)
		WD 5	267..308		31/40 (78%)
		WD 6	313..354		26/40 (65%)
		WD40 repeat	320..356	CDD:293791	23/35 (66%)
		WD 7	358..398		30/39 (77%)
		WD40 repeat	363..388	CDD:293791	19/24 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		14/51 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..498		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..631		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..703		23/58 (40%)
dtl	NP_775348.1	WD40 repeat	46..95	CDD:293791	29/51 (57%)
		WD 1	48..88		26/42 (62%)
		WD40	<68..387	CDD:225201	225/325 (69%)
		WD40	68..384	CDD:238121	222/322 (69%)
		WD 2	95..134		26/38 (68%)
		WD40 repeat	100..136	CDD:293791	24/35 (69%)
		WD 3	137..177		34/39 (87%)
		WD40 repeat	143..185	CDD:293791	35/41 (85%)
		DDB1-binding motif. /evidence=ECO:0000250	167..170		2/2 (100%)
		WD 4	209..248		29/38 (76%)
		WD40 repeat	214..307	CDD:293791	65/92 (71%)
		DDB1-binding motif. /evidence=ECO:0000250	238..241		2/2 (100%)
		WD 5	264..303		30/38 (79%)
		WD40 repeat	269..299	CDD:293791	22/29 (76%)
		WD 6	308..349		26/40 (65%)
		WD40 repeat	315..352	CDD:293791	23/36 (64%)
		WD 7	353..393		33/43 (77%)
		WD40 repeat	358..383	CDD:293791	19/24 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..487		34/101 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..647		36/153 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194326458
Domainoid	1	1.000	96	1.000	Domainoid score	I26839
eggNOG	1	0.900	-	-		E1_KOG0321
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32313
Inparanoid	1	1.050	601	1.000	Inparanoid score	I5258
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40939
OrthoDB	1	1.010	-	-		D1288134at2759
OrthoFinder	1	1.000	-	-		FOG0005579
OrthoInspector	1	1.000	-	-		oto51642
orthoMCL	1	0.900	-	-		OOG6_104235
Panther	1	1.100	-	-	LDO	PTHR22852
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4627
SonicParanoid	1	1.000	-	-		X4553
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300