DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DTL and cdt-2

DIOPT Version :9

Sequence 1:	NP_057532.4	Gene:	DTL / 51514	HGNCID:	30288	Length:	730	Species:	Homo sapiens
Sequence 2:	NP_506685.2	Gene:	cdt-2 / 179995	WormBaseID:	WBGene00011318	Length:	682	Species:	Caenorhabditis elegans

Alignment Length:	783	Identity:	174/783 - (22%)
Similarity:	299/783 - (38%)	Gaps:	204/783 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    22 QYP------LQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYN 80
            :||      |:|..........|:|.::         ....||...|.||:|.:.::.|.:.:::
Worm    15 RYPSSIYEELESKHYSMPAGETDDHDTW---------VTARFSPHLNQEHILYMGDDPGNIGIFD 70

Human    81 TESQSFRKKCFKE-----WMAHWNAVFDLAWVP-GELKLVTAAGDQTAKFWDVKAGELIGTCK-- 137
            ......|....:|     :.||..|:.|:..|| .|.::|:.:||.|.:.||:....|....:
Worm    71 VRKFQDRSVPLEERQLYFFPAHDGAIMDVVGVPQKESQIVSISGDSTIRCWDLNQSTLDRKSQVF 135

Human   138 -GHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSK-- 199
             ||:.|::|:.|:..:..||.|||||..:.:||.|.:............:..:.|:..: |||
Worm   136 FGHEGSVRSICFAPDDPNVFVTGGRDFQVKIWDMRVSTVKKMEEDCRMATITYKTAHPK-PSKVL 199

Human   200 ----PKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGA-VDGIIKVWDLRKNYTAYRQEPIAS 259
                ||.|..:|.:.     ...||.|||.||:.:.||.. .|..|:|||:||.......:|  :
Worm   200 TSGTPKSKAKAKTIE-----GYKVTSVLFLDEHHVASASENADSGIRVWDIRKPTRNGEGQP--A 257

Human   260 KSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSS 324
            :....|.|:.:..|.:.|.||..|:.|||:|||.:|:.:::.....||:..:.|.....||.:.:
Worm   258 RILKVPTSNKKSYGVTCLTLDRFGNRLFASCTDSSIFEYSVPSESVSPINSYTGATIHNFYTQVA 322

Human   325 LSPDDQFLVSGSSDEAAYIWKVSTPWQ------------------PPTVLLGHSQEVTSVCWCPS 371
            .||....:..||.|..|.:|.:...:.                  |.....||.::|.:|.| .|
Worm   323 CSPVSDVIACGSEDSRAVVWDLQDQYNYMNDRKLPDDIDKRRTKLPRFSCDGHLKQVLNVGW-SS 386

Human   372 DFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGW-ASQKKKESRPGLVTVTSSQSTPAKAPR 435
            ..|...:| |:..::||           .:..:...| .:.:...|.|     |:||.......:
Worm   387 RGTYFMSC-DEGGVRIW-----------SEPRNRCTWKLNDEDDTSYP-----TTSQELGLSYEK 434

Human   436 AKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAK-------ARSPINRRGSVSSVSPKP 493
            .|......|..:.:|..               ||..||.:       :.||...|||...:
Worm   435 IKKFELKESDEAMSCFD---------------SISLSPRQRADSSGLSGSPQKNRGSKRPI---- 480

Human   494 PSSFKMSIRNWVTRTPSSSPPI----TPPASETKI-MSPRKALIPVSQKSSQAEACSESRNRVKR 553
               |:..:::..|.:|.   |:    :|.|..:|: .||...|.|.:         |.:::.|..
Worm   481 ---FESPLKSICTNSPK---PLRLNRSPRAKMSKLSFSPPSPLQPTN---------SNNQDLVGY 530

Human   554 RLDSSCLESVKQKCVKSCNCVTE--LDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGT 616
            |..    ..::.|..|:.....|  .:| :.|...|         ...|..:|.:..|.||.:|.
Worm   531 RTP----RQIRNKKKKNNPFYNEHPTEG-LPNFVYD---------TFVKKLIGESSKSDIEDSGK 581

Human   617 SISEP------------------------PSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSP 657
            |:|:.                        || :|.:...:|             |:::.::..
Worm   582 SLSKTGQKRIEDWWQTKGENVATVTRARLPS-VSEFGESAC-------------SKVITEDER-- 630

Human   658 ENKNWLLAMAAKRKAENPSPRSPSSQTP---NSRRQSGKKLPSPVTITP-------SSMRKICTY 712
                  :|:.:.||.   ..:|.|:|:|   ||:       |.|:.:||       .:.|.:..|
Worm   631 ------IALHSPRKL---VLKSSSTQSPCPSNSK-------PKPIPMTPRKPMDKRPTSRNLLHY 679

Human   713 FHR 715
            |.:
Worm   680 FKK 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DTL	NP_057532.4	WD 1	47..89		8/41 (20%)
		WD40	55..389	CDD:238121	100/367 (27%)
		WD40 repeat	55..96	CDD:293791	9/45 (20%)
		WD 2	96..135		14/39 (36%)
		WD40 repeat	101..137	CDD:293791	11/36 (31%)
		WD 3	138..178		15/39 (38%)
		WD40 repeat	144..197	CDD:293791	13/52 (25%)
		DDB1-binding motif	168..171		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..210		8/27 (30%)
		Nuclear localization signal. /evidence=ECO:0000255	197..203		5/11 (45%)
		WD 4	214..253		16/39 (41%)
		WD40 repeat	219..312	CDD:293791	33/93 (35%)
		DDB1-binding motif	243..246		2/2 (100%)
		WD40 repeat	264..304	CDD:293791	14/39 (36%)
		WD 5	267..308		14/40 (35%)
		WD 6	313..354		11/58 (19%)
		WD40 repeat	320..356	CDD:293791	9/53 (17%)
		WD 7	358..398		11/39 (28%)
		WD40 repeat	363..388	CDD:293791	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..498		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..631		11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..703		12/61 (20%)
cdt-2	NP_506685.2	WD40	39..403	CDD:392136	102/393 (26%)
		WD40 repeat	44..91	CDD:293791	9/46 (20%)
		WD40 repeat	96..136	CDD:293791	11/39 (28%)
		WD40 repeat	143..187	CDD:293791	12/43 (28%)
		WD40 repeat	218..261	CDD:293791	17/44 (39%)
		WD40 repeat	272..310	CDD:293791	13/37 (35%)
		WD40 repeat	318..342	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0321
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4390
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005579
OrthoInspector	1	1.000	-	-		oto21999
orthoMCL	1	0.900	-	-		OOG6_104235
Panther	1	1.100	-	-	LDO	PTHR22852
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4627
SonicParanoid	1	1.000	-	-		X4553
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.680