DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDE7A and Pde11

DIOPT Version :9

Sequence 1:	NP_001229247.1	Gene:	PDE7A / 5150	HGNCID:	8791	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	89/345 - (25%)
Similarity:	161/345 - (46%)	Gaps:	31/345 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   150 KVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNA 214
            ::.::.||...|:    .:..:.....:|.....:|.||:|...|.|:|:.::::|.:.. |||.
  Fly   803 RLHDFKFDDIHFE----DDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVT-YHNW 862

Human   215 VHAADVTQAMHCYLKEPKLANSVTPW-------DILLSLIAAATHDLDHPGVNQPFLIKTNHYLA 272
            .||.:|.|.|...|       :.|.|       :.|..:|....|||||.|.|..|.||.:..||
  Fly   863 RHAFNVAQMMFAIL-------TTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLA 920

Human   273 TLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRS 335
            .|| :||.:|:||:...:.:|...|  :.::|..:...::...:...||:||::...:....|..
  Fly   921 QLY-STSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLE 984

Human   336 HLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 400
            .:.:..........|.|:..|::...|:....:.||:.|:.::.|:.|||.|||:||: .|.::|
  Fly   985 SVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQ-ELNITP 1048

Human   401 --LCDRHTE-SIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSE 462
              :.:|..| .:..:|:.|:..:..|::..:|..|: :|...:.| |..|:..|..|.....:..
  Fly  1049 IDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSD-KLEPLVEG-VRDNRGHWIDLADVVKTKT 1111

Human   463 DTDAAFELNSQLLPQENRLS 482
            ..|...|...|   |:|.:|
  Fly  1112 SQDQEPEEEQQ---QQNVIS 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDE7A	NP_001229247.1	PDEase_I	211..444	CDD:395177	67/244 (27%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	67/245 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750