DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKFY1 and ankfy1

DIOPT Version :9

Sequence 1:	XP_016880222.1	Gene:	ANKFY1 / 51479	HGNCID:	20763	Length:	1273	Species:	Homo sapiens
Sequence 2:	XP_005171962.1	Gene:	ankfy1 / 568480	ZFINID:	ZDB-GENE-041222-1	Length:	1167	Species:	Danio rerio

Alignment Length:	1172	Identity:	984/1172 - (83%)
Similarity:	1072/1172 - (91%)	Gaps:	12/1172 - (1%)

- Green bases have known domain annotations that are detailed below.

Human   107 EQEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQA----NKESSSESFISRLLAIVADLYE 167
            |:||.||:|||.||||||||:|:||.|||:||::|||||    :...:|:||||||||||:|||:
Zfish     3 EEEVQKLQKHLALLRQEYVKMQQKLVETERRCSVLAAQASVPGSSSQASDSFISRLLAIVSDLYQ 67

Human   168 QEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEF 232
            ||||||||:|:||:.:|||||||||||:.||||||:||.|||||||.|||.|.||||.|||:||.
Zfish    68 QEQYSDLKVKIGDQRLSAHKFVLAARSEIWSLANLASTSELDLSDAKPEVAMAMLRWTYTDDLEL 132

Human   233 REDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASH 297
            ..:|.||.:||||||||||.||||||||||||.||||||||||||||||:|:||||||.||||||
Zfish   133 NGNDGFLIDLMKLANRFQLHLLRERCEKGVMSSVNVRNCIRFYQTAEELDAATLMNYCGEIIASH 197

Human   298 WDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDL 362
            ||||||||||:|.||||||||||||||||||||||||||||||||||||:||||||||.|:||||
Zfish   198 WDDLRKEDFSTMDAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDAQLPGKLNELDNNGDL 262

Human   363 ALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQ 427
            |||||||::|||||||||::||||||||:||||||||.|||||.||:||||::.|.|||||:||.
Zfish   263 ALDLALSKKLESIATTLVNNKADVDMVDQSGWSLLHKAIQRGDEFASTFLIRHSAQVNAATVGAV 327

Human   428 ETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 492
            |||||||..:|.||||.:||:.||:||||||:||||||||:||||||||.::::|||.||:||||
Zfish   328 ETPLHLVCSFSPKKHSGEVMAGMARIAEALLKAGANPNMQNSKGRTPLHEAVVSGNEPVFNQLLQ 392

Human   493 CKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFED-VPVVNGTSFDENSFAARLIQRGSHTDA 556
            ||||||||||||||||||||:|:|||:||.||||||| .||||||||||||||||||||||:.||
Zfish   393 CKQLDLELKDHEGSTALWLALQYITVASDPSVNPFEDEAPVVNGTSFDENSFAARLIQRGSNPDA 457

Human   557 PDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANP 621
            ||| .||||:||||.||:||||:||||:||.|||.|||||||||||||.|||.||.|||||||||
Zfish   458 PDT-NGNCLMQRAAVAGSEAAAIFLATHGAKVNHTNKWGETPLHTACRCGLAGLTVELLQQGANP 521

Human   622 NLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDF 686
            ||||:.|||...|.      :..|..|:|||:||.:|||||||||||||||||||||||||||||
Zfish   522 NLQTDIALPGGVEK------SQGVSQQSPLHLAIVHNHPDVVSVILEQKANALHATNNLQIIPDF 580

Human   687 SLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQAD 751
            |||||.||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
Zfish   581 SLKDSMDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIKRQDSKSALFLLEHQAD 645

Human   752 INVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGC 816
            ||||||:|:|||||||.|||||||||||||||||||.:|||:|||||||.|.|||||||||||||
Zfish   646 INVRTQEGQTALQLAISNQLPLVVDAICTRGADMSVVNEKGDPPLWLALENGLEDIASTLVRHGC 710

Human   817 DATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLA 881
            |||||..|||||.|||||||||||||.||||||||||||||.|:||.||||:|||||||.|||||
Zfish   711 DATCWSSGPGGCQQTLLHRAIDENNEVTACFLIRSGCDVNSSRRPGPNGEGDEEARDGQCPLHLA 775

Human   882 ASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFA 946
            |||||||..||||||||||||||:|||.|||||||:|..||||||:|||:|.||:|||||:||||
Zfish   776 ASWGLEEVAQCLLEFGANVNAQDSEGRAPIHVAISNQQSVIIQLLISHPEIRLNIRDRQGMTPFA 840

Human   947 CAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKL 1011
            ||||.||||:||||||||.||||||||||||||||||||||||||||||||.|||||||||::||
Zfish   841 CAMTHKNNKAAEAILKREPGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVQANVNSRVQDSAKL 905

Human  1012 TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENG 1076
            :|||||||||||||||||||||||||||||||||||||||||||.||||||:|||||||||||||
Zfish   906 SPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLSTICSVLIENGVDFAAVDENG 970

Human  1077 NNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPL 1141
            |||||||||.|||||:|.||||..|||||:|||||||:|:|||||||||||||:|||||||.|||
Zfish   971 NNALHLAVMQGRLNNVRALLTESNVDAEAYNLRGQSPMHVLGQYGKENAAAIFELFLECMPEYPL 1035

Human  1142 DKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEP 1206
            ||||.:|:||||||||||||||||||||:||||||.||||:||||||||||||||||||||||||
Zfish  1036 DKPDNEGNTVLLLAYMKGNANLCRAIVRAGARLGVTNNQGINIFNYQVATKQLLFRLLDMLSKEP 1100

Human  1207 PWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGG 1271
            ||||||.||||..:||||||||||||||||||||||.|||||||||||||||||:||||||||||
Zfish  1101 PWCDGSNCYECITKFGVTTRKHHCRHCGRLLCHKCSIKEIPIIKFDLNKPVRVCDICFDVLTLGG 1165

Human  1272 VS 1273
            ||
Zfish  1166 VS 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKFY1	XP_016880222.1	None
ankfy1	XP_005171962.1	BTB	64..160	CDD:279045	72/95 (76%)
		BTB	73..160	CDD:197585	64/86 (74%)
		BACK	171..>239	CDD:197943	62/67 (93%)
		ANK repeat	225..257	CDD:293786	30/31 (97%)
		Ank_2	226..321	CDD:289560	79/94 (84%)
		ANK	254..391	CDD:238125	102/136 (75%)
		ANK repeat	259..290	CDD:293786	26/30 (87%)
		ANK repeat	292..323	CDD:293786	23/30 (77%)
		Ank_2	297..402	CDD:289560	77/104 (74%)
		ANK repeat	325..368	CDD:293786	31/42 (74%)
		ANK	365..561	CDD:238125	153/202 (76%)
		ANK repeat	370..402	CDD:293786	24/31 (77%)
		ANK repeat	494..525	CDD:293786	27/30 (90%)
		Ank_2	499..616	CDD:289560	97/122 (80%)
		ANK repeat	540..572	CDD:293786	25/31 (81%)
		ANK	542..672	CDD:238125	120/129 (93%)
		ANK repeat	586..617	CDD:293786	29/30 (97%)
		ANK repeat	619..650	CDD:293786	29/30 (97%)
		Ank_2	624..711	CDD:289560	77/86 (90%)
		ANK repeat	652..683	CDD:293786	27/30 (90%)
		ANK repeat	685..710	CDD:293786	21/24 (88%)
		Ank_2	690..798	CDD:289560	94/107 (88%)
		ANK repeat	724..765	CDD:293786	35/40 (88%)
		ANK	762..924	CDD:238125	140/161 (87%)
		ANK repeat	767..798	CDD:293786	27/30 (90%)
		Ank_2	772..858	CDD:289560	71/85 (84%)
		ANK repeat	800..832	CDD:293786	23/31 (74%)
		ANK repeat	834..867	CDD:293786	28/32 (88%)
		ANK	864..990	CDD:238125	116/125 (93%)
		ANK repeat	873..901	CDD:293786	26/27 (96%)
		ANK repeat	906..934	CDD:293786	26/27 (96%)
		Ank_2	908..1001	CDD:289560	85/92 (92%)
		ANK	931..1062	CDD:238125	115/130 (88%)
		ANK repeat	936..967	CDD:293786	28/30 (93%)
		FYVE_ANFY1	1099..1161	CDD:277267	55/61 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329007
Domainoid	1	1.000	209	1.000	Domainoid score	I12166
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9491
Inparanoid	1	1.050	1967	1.000	Inparanoid score	I477
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52170
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	1	1.000	-	-		FOG0007415
OrthoInspector	1	1.000	-	-		oto52117
orthoMCL	1	0.900	-	-		OOG6_105751
Panther	1	1.100	-	-	LDO	PTHR24118
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3101
SonicParanoid	1	1.000	-	-		X5546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440