Protein Alignment PDE6C and Pde11

DIOPT Version :9

• Sequence 1: NP_006195.3
• Gene: PDE6C / 5146
• HGNCID: 8787
• Length: 858
• Species: Homo sapiens
• Sequence 2: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 817
• Identity: 266/817 - (32%)
• Similarity: 416/817 - (50%)
• Gaps: 85/817 - (10%)

Human    48 MSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPE--- 109
            :|.:||.|::|..|..||:..:..|... ....|:.||.::.||.|||.|:||.:.|...|:
  Fly   393 LSRNELKQLDEKELIFELVKDICNELEV-RTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLK 456

Human   110 --VASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQT 172
              :.|:|.||.|.|..|:  :....||......||.|..|.:.:..|:||..::..|:..:|..|
  Fly   457 KCLVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLT 519

Human   173 GYVTKNLLATPIVVGK-EVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIE 236
            ||.||.||..||.... :|:.|...:||:|...||:.||:|||.||.|..|.||.........:|
  Fly   520 GYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLE 584

Human   237 SRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEV 301
            .:|:|:|:..|..:|||.:.:|....:.|..::|.:.|:|..|.|:.
  Fly   585 IKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVH------------------ 631

Human   302 EPYKGPKTPDGREVNFYKIIDYILH--GKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNA 364
            |..||         :|.::.|:..:  .:||.....:|....:.:..|:..:||..|...|:.||
  Fly   632 EADKG---------SFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNA 687

Human   365 PADEYFTFQKGPVDETG-WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQF 428
            ..|:.|   ...|||.. :..:::|.:.|.|....|:||....|:.:...|.::||...|....|
  Fly   688 YEDDRF---DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIF 749

Human   429 LGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAI 493
            .|..:.||..|:|......::.:..|:|.....||.:|...:.:.:
  Fly   750 CGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLR------------------- 795

Human   494 LKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRA 558
                :|......|::|:|.|....:...:|..:|:|.:::.||:|.:..|||.||:.:|:|.||.
  Fly   796 ----VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRN 856

Human   559 VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLAR 623
            ||||||||.|||.|.||.:|.|.:..|.:.::|..|::....|||:|||||||.:|:|::||||:
  Fly   857 VTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQ 921

Human   624 LHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIV 688
            |:.:|.:|.||.:....:|......|..||:...:..||.:.|.||::||||:|||||..|.:.|
  Fly   922 LYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESV 986

Human   689 DACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLER 753
                    .:....:|..:|  :.::.||.||.|||||||||||::.:||.:|::||:||||:|:
  Fly   987 --------SQPTSYWVAEEP--RALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEK 1041

Human   754 TVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADE 818
            ..|...||.:|:|.|.||||.:||.|||.:|..:|:.|:....::.|::.|:::||..|..|||.
  Fly  1042 QELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV 1106

Human   819 YDAKMKVIEEEAKKQE------GGAEKAAEDSGGGDD 849
            ...|....:|..::|:      .|..||..|    ||
  Fly  1107 VKTKTSQDQEPEEEQQQQNVISNGDCKAMSD----DD 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE6C	NP_006195.3	GAF	80..231	CDD:214500	58/156 (37%)
		GAF	256..443	CDD:214500	44/189 (23%)
		PDEase_I	561..806	CDD:278654	105/244 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	830..858		7/26 (27%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	58/164 (35%)
		GAF	611..762	CDD:214500	42/180 (23%)
		PDEase_I	859..1094	CDD:278654	105/244 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750