DRSC/TRiP Functional Genomics Resources

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Protein Alignment PDE4D and Pde8

DIOPT Version :10

Sequence 1:NP_001098101.1 Gene:PDE4D / 5144 HGNCID:8783 Length:809 Species:Homo sapiens
Sequence 2:NP_001163275.2 Gene:Pde8 / 37741 FlyBaseID:FBgn0266377 Length:1050 Species:Drosophila melanogaster


Alignment Length:585 Identity:164/585 - (28%)
Similarity:253/585 - (43%) Gaps:145/585 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   153 FDVDNGTSAGRSPL-DPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDI 216
            |||..|.....:.| .|..:|...|       ||.||.||..|                ||||| 
  Fly   553 FDVPGGQMDFIATLPQPKEAPRGSL-------HSVRRCSFDVR----------------SIASD- 593

Human   217 HGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETL 281
                           .||  |.:.|.||:|...||                ||:           
  Fly   594 ---------------GLR--RTSLAKLTSLPLEAP----------------ITK----------- 614

Human   282 EELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI 346
                 .::.|..:|...|..|      .|::::.|..|   .|.|                   :
  Fly   615 -----IINLLSQVQENCSADE------ARLIDKVLEFL---KREG-------------------L 646

Human   347 PSPTQKEKEKKKRPMSQISGV----KKLMHSSSLTNSSIPRFG----------VKTEQEDVLAKE 397
            .||..||........:.:.|.    ..:..|...:|.||.|.|          .|.:...::.:.
  Fly   647 YSPQMKEIRTDDPIATDLIGALLTGPSVYSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMEL 711

Human   398 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH 462
            |::...|...:|::.|::...||..:...:|:..|:..|..|..:....:|..:|.||.....||
  Fly   712 LDESLSWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKAWLAVIEAHYRKSNTYH 776

Human   463 NNIHAADVVQSTHVLLS--TPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMY 525
            |:.|||||:|:|...::  |.....|...:|...|:.|:|.|||||||.|:.||.|:|..||::|
  Fly   777 NSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLY 841

Human   526 NDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV 589
            ||.:||||||.|:.||| |.::..:||:||.|:..:|.|..:||::|||:|::|...||...::.
  Fly   842 NDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVF 906

Human   590 ----------ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFR 644
                      :|.:.||            |.:.:.::..||:|||.:|:|...:|..||.||:|.
  Fly   907 GGEEPRDHNPQTDEETS------------ILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFM 959

Human   645 QGDRERERGMEI-SPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN-REW 707
            |.|.|::|.:.| .||.|:...|:.|||:|||:||:..:...|...:  |...::..::.| .:|
  Fly   960 QTDEEKQRHLPIVMPMFDRATCSIPKSQIGFIEYIIQDMMHAWESFI--DMPQLITYMQINYSQW 1022

Human   708  707
              Fly  1023  1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDE4DNP_001098101.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..107
PDE4_UCR 223..339 CDD:465648 20/115 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 343..364 4/20 (20%)
PDEase_I 461..701 CDD:459723 96/253 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..729
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 739..809
Pde8NP_001163275.2 NtrB 446..>539 CDD:443061
PDEase_I 775..1016 CDD:459723 96/254 (38%)
Blue background indicates that the domain is not in the aligned region.

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