Protein Alignment PDE4D and Pde11

DIOPT Version :9

• Sequence 1: NP_001098101.1
• Gene: PDE4D / 5144
• HGNCID: 8783
• Length: 809
• Species: Homo sapiens
• Sequence 2: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 1012
• Identity: 212/1012 - (20%)
• Similarity: 367/1012 - (36%)
• Gaps: 296/1012 - (29%)

Human     9 PARAGSGEGS----DSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQP 69
            |...||..||    .:.||..  |.::.:.|:|||            |.|.||........|
  Fly   297 PMDNGSVGGSCSNLQNVGGVV--AGQYQYNHQQHH------------HNHAHLHHSQHSHYQ--- 344

Human    70 QCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDT----------ERYLY------- 117
                              .|.|.|. :|.|:||.....|.:.:          .:|.|
  Fly   345 ------------------AGGAVGS-SSLGSTGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRP 390

Human   118 ------------------------CRAM-------------------DRTSYAVETGH---RPGL 136
                                    |..:                   ||.|..:..|.   ..||
  Fly   391 QRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGL 455

Human   137 KKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSP-------GSGL---ILQA----NFVHSQR 187
            ||..:|        :.|||     ..||.::.|...       |:|:   :.::    |...:.:
  Fly   456 KKCLVS--------KLFDV-----CPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507

Human   188 RESFLYRSDSDYDLSPKSM----SRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQD 248
            .|.|....||......|::    .::||      ||   |...|||:..:     |....:.:.:
  Fly   508 DERFNCEIDSLTGYRTKALLCMPIKDSS------GD---VIGVAQVINKM-----NGECFSEIDE 558

Human   249 RAPSKRSPMC------------NQPSINKATITEEAYQKLASE--TLEELDW-------CLDQLE 292
            :..|.....|            :|..|.:..:..:..:.:..|  |:|.:.:       .|.|.:
  Fly   559 KVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQ 623

Human   293 TLQTRHSVSEMASNKFKRMLNRELTHLSE---MSRSGNQVSEF-----ISNTFLDKQHEVEIPSP 349
            .:|.. .|.|.....|.|:.:.|...|||   .||:....|.|     |:.........|.:|:.
  Fly   624 RVQIL-LVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNA 687

Human   350 TQKE------------KEKK------KRPMSQISGVKKL-------------------------- 370
            .:.:            |.:.      |..:.||.||.:|
  Fly   688 YEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGM 752

Human   371 -MHSSSLTNSSIPRFGVKTEQEDVL----AKELEDVNK-----------WGLHVFRIAEL--SGN 417
             :|::.:...:|.....::...:||    :..:::.::           :.||.|:..::  ..:
  Fly   753 GIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDD 817

Human   418 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA 482
            ..|...:. :|.:.|.::.|.|..:.|..:|::::.:|. :|.|||..||.:|.|....:|:|..
  Fly   818 DTLKACLR-MFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQ 880

Human   483 LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEEN 547
            ...:|.::|.||.|.....||:||.|.:|.|.|..:|.||.:|: :|.:|:||......:|....
  Fly   881 WWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPG 944

Human   548 CDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVL 612
            ..|..||:......:.:::.|.:|:||::.:.......  :....:.||..|      ::..:.|
  Fly   945 NQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPRAL 1001

Human   613 ---QNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS---- 670
               .:|..| |||..|||.::.::..|.:..|||.|||.|::. :.|:|: |..|...|..
  Fly  1002 LRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPI-DIMNREKEDELPMM 1063

Human   671 QVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNR-EWYQ-STIPQSPSPAPDDPEEGRQGQT-- 731
            ||.|||.|..|::|.:|.| ....:.:::.:.||| .|.. :.:.::.:....:|||.:|.|.
  Fly  1064 QVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVI 1127

Human   732 -----------EKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIP------ 779
                       :....|..:..|..|:....:||.|..::|.::.|........||: |
  Fly  1128 SNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQ-PSDDDND 1191

Human   780 -------LDEQVEEEAVGEEEESQPEACVIDDRSPDT 809
                   :|||..||. |.:.|....:|    ||..|
  Fly  1192 VDADADDVDEQAAEEN-GHDAEVDEASC----RSNST 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE4D	NP_001098101.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107		24/101 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364		4/38 (11%)
		PDEase_I	461..702	CDD:278654	73/247 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..729		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..809		20/82 (24%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	34/188 (18%)
		GAF	611..762	CDD:214500	26/151 (17%)
		PDEase_I	859..1094	CDD:278654	73/247 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154159
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750