Protein Alignment PDE4D and dnc

DIOPT Version :10

• Sequence 1: NP_001098101.1
• Gene: PDE4D / 5144
• HGNCID: 8783
• Length: 809
• Species: Homo sapiens
• Sequence 2: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 979
• Identity: 449/979 - (45%)
• Similarity: 563/979 - (57%)
• Gaps: 235/979 - (24%)

Human     8 APARAGSGEGSDSAGGATLK----APKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP-------- 60
            |.|...||..:..|...||.    :|..:.:.:|..|..|:||   ||....|..|.
  Fly   212 AAASLASGLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQP---LLQSQPHFVPSSGNILSQV 273

Human    61 -------------------------PPPSPQP-------QPQCPLQPPPPP-------------- 79
                                     |.|:..|       |.:|..||...|
  Fly   274 TLYSGSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQAN 338

Human    80 -----------PLPPP---------------------------PP-------------------- 86
                       |||||                           ||
  Fly   339 FKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRI 403

Human    87 ------------------PPGAARG--------------RYASSGATG--RVRHRGYSDTERYLY 117
                              |.|:|.|              ..|||..||  ....:..|......:
  Fly   404 KLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAH 468

Human   118 CRAMDRTSYAVETGHRPG---LKKSRM-----------SWPSSFQGLR-------RFDVDNGTSA 161
            .|....::.|:.|.|...   |..|:|           .:.|.:...|       ||||:||..|
  Fly   469 HRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGA 533

Human   162 GRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASD----------- 215
             ||||:. .||.:||:|| |.  .|||||||||||||:::|||||||||||||:
  Fly   534 -RSPLEG-GSPSAGLVLQ-NL--PQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILV 593

Human   216 --IHGDDLIVTPFAQVLASLRTVRNNFAALTNL----QDRAPSKRSPMCNQPSINKATIT--EEA 272
              .||:|||||||||:|||||:||||..:|||:    :.|.|::.|......:...|.::  |||
  Fly   594 DRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEA 658

Human   273 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTF 337
            |.:||::|:||||||||||||:||..|||:|||.|||||||:||:|.||.||||||:||:|.:||
  Fly   659 YTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTF 723

Human   338 LDKQHEVEIP--------------------SPTQKEKEKKKR--PMSQISGVKK-LMHSSSLTNS 379
            ||||.|.::|                    |..|..:.:..|  |||||||||: |.|::|.|..
  Fly   724 LDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGE 788

Human   380 SIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTL 444
            .:|.|||:|.:|:.|...|.:::.||:.:|.|.|.|.|||||.:.:||||.|:||.:..||..|.
  Fly   789 RLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTF 853

Human   445 ITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV 509
            :.::.||||||..|..:||::|||||.|||:|||:|||||.|||.||:..|:||:.||||||||:
  Fly   854 LNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGL 918

Human   510 SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATD 574
            :||||:|::|||||||||.||||||||||.|||||.:.||||.|:.|||||:||||||||||:||
  Fly   919 TNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTD 983

Human   575 MSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIM 639
            |||||:||||||||||||||..|||||||||:||||||:|:|||||||||||||.||::|...:|
  Fly   984 MSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLM 1048

Human   640 EEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDN 704
            ||||.|||:|||.||:||||||:|||::|||||||||||||||||||||||||||||||||||:|
  Fly  1049 EEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEEN 1113

Human   705 REWYQSTIPQSPSPA--PDDPEEGRQGQTEKFQFELTLEE-DGESDTEKDSGSQVEEDTSCSDSK 766
            |::|||.||.||.|:  .::|:|      ::.:|::|||| |.|:..|.:.|     |.|..:|.
  Fly  1114 RDYYQSMIPPSPPPSGVDENPQE------DRIRFQVTLEESDQENLAELEEG-----DESGGEST 1167

Human   767 TLCT 770
            |..|
  Fly  1168 TTGT 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE4D	NP_001098101.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..107		41/248 (17%)
		PDE4_UCR	223..339	CDD:465648	72/121 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364		8/42 (19%)
		PDEase_I	461..701	CDD:459723	190/239 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..729		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..809		13/33 (39%)
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	72/121 (60%)
		PDEase_I	870..1110	CDD:459723	190/239 (79%)