Protein Alignment SNX9 and VPS5

DIOPT Version :10

• Sequence 1: NP_057308.1
• Gene: SNX9 / 51429
• HGNCID: 14973
• Length: 595
• Species: Homo sapiens
• Sequence 2: NP_014712.2
• Gene: VPS5 / 854235
• SGDID: S000005595
• Length: 675
• Species: Saccharomyces cerevisiae
• Alignment Length: 672
• Identity: 134/672 - (19%)
• Similarity: 245/672 - (36%)
• Gaps: 168/672 - (25%)

Human    14 EPGNNELTVNEGEIITITNPDVGGGWLE-GRNIKGERGLVPTDYVEILPSDGKDQFSCGNSVA-D 76
            |..:|||...........:.|....|.: |.::.|...|...|     .|...|..   ||:| :
Yeast    41 ERKDNELLETTASFADKIDLDSAPEWKDPGLSVAGNPQLEEHD-----NSKADDLI---NSLAPE 97

Human    77 QAFLDSLSASTAQASSSAASNNHQ-VGSGNDPW----SAWSASKSGNWESSEGW--GAQP----E 130
            |..:..|..||.|..::..|.... .|:.|.|.    :.:.|:.|.|...|...  ..:|    :
Yeast    98 QDPIADLKNSTTQFIATRESGGALFTGNANSPLVFDDTIYDANTSPNTSKSISGRRSGKPRILFD 162

Human   131 GAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGP----KSSSYFKDSESADAGGAQR 191
            .|.||||:...::....         ..|..||.....:..|    :..:.|.:....|....:.
Yeast   163 SARAQRNSKRNHSLKAK---------RTTASDDTIKTPFTDPLKKAEKENEFVEEPLDDRNERRE 218

Human   192 GNSRASSSSMK--------IPLNKFP----GFAKPGTEQYLLAKQLAKPK--EKIPIIVGDYGPM 242
            .|....::|::        .||...|    ..:.| .|....:::..|.|  .|:|
Yeast   219 NNEGKFTASVEKNILEQVDRPLYNLPQTGANISSP-AEVEENSEKFGKTKIGSKVP--------- 273

Human   243 WVYPTS---TFDCVVADPRKGSKMYGLKSYIEYQLTPTNT-----NRSVNHRYKHFDWLYERLLV 299
               ||.   .|...|.||.|..::..:  ::||.:...::     ...|:.||:.|.|||.:|..
Yeast   274 ---PTEKAVAFKVEVKDPVKVGELTSI--HVEYTVISESSLLELKYAQVSRRYRDFRWLYRQLQN 333

Human   300 K-FGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRD----- 358
            . :|..||.|  |:||..|.|:|.||:.|..::::.:.::|:.||:.:.:.|..||...|
Yeast   334 NHWGKVIPPP--PEKQSVGSFKENFIENRRFQMESMLKKICQDPVLQKDKDFLLFLTSDDFSSES 396

Human   359 -EKEWKTGKRKA-ERDELAGVMIFSTMEPEAPDLDLVEIEQKCE--------------------- 400
             ::.:.||.... :.::|:.|.|        .::.|:..|...|
Yeast   397 KKRAFLTGSGAINDSNDLSEVRI--------SEIQLLGAEDAAEVLKNGGIDAESHKGFMSISFS 453

Human   401 AVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAIT 465
            ::.|:.:|.:..:::         |:....|....:|:.|:|:.:.|        ....|..:..
Yeast   454 SLPKYNEADEFFIEK---------KQKIDELEDNLKKLSKSLEMVDT--------SRNTLAASTE 501

Human   466 EAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKIT 530
            |.....|.:|||...:|..:|             |..|.|:..:.|.::|:....:.|  |..:.
Yeast   502 EFSSMVETLASLNVSEPNSEL-------------LNNFADVHKSIKSSLERSSLQETL--TMGVM 551

Human   531 LQDKQNMVKRV-------SIMSY---ALQAEMNHFHS------NRIY---------DYNSVIRLY 570
            |.|....:..|       |.:.|   .::.:||..||      ..|:         ::.::.|.|
Yeast   552 LDDYIRSLASVKAIFNQRSKLGYFLVVIENDMNKKHSQLGKLGQNIHSEKFREMRKEFQTLERRY 616

Human   571 LEQQVQFYETIAEKLRQALSRF 592
            ...:.| ::.:.:|::.....|
Yeast   617 NLTKKQ-WQAVGDKIKDEFQGF 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX9	NP_057308.1	SH3_SNX9	4..60	CDD:212831	10/46 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..201		21/124 (17%)
		Critical for tubulation activity	201..213		3/23 (13%)
		PX_SNX9	250..375	CDD:132818	37/137 (27%)
		BAR_SNX9	386..595	CDD:153352	41/253 (16%)
VPS5	NP_014712.2	PX_Vps5p	281..390	CDD:132771	34/112 (30%)
		BAR_Vps5p	460..673	CDD:153311	37/211 (18%)