Protein Alignment SNX9 and snx9b

DIOPT Version :10

• Sequence 1: NP_057308.1
• Gene: SNX9 / 51429
• HGNCID: 14973
• Length: 595
• Species: Homo sapiens
• Sequence 2: XP_021324123.1
• Gene: snx9b / 558917
• ZFINID: ZDB-GENE-031118-50
• Length: 620
• Species: Danio rerio
• Alignment Length: 628
• Identity: 395/628 - (62%)
• Similarity: 467/628 - (74%)
• Gaps: 41/628 - (6%)

Human     1 MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGK 65
            |.:||:|:||||||||||||:|.|||.|||||.::||||:|.||.:||.||||.||:||  :..:
Zfish     1 MESKAQVLYDFAAEPGNNELSVREGETITITNQNIGGGWIEARNSRGEVGLVPEDYIEI--NQAQ 63

Human    66 DQFSCGNSV-ADQAFLDS---LSASTAQASSS----------------AASNNHQVGSGNDPWSA 110
            ...|.||:. .|.:|.||   ..|||||...:                .:::..:..:|||||:.
Zfish    64 PLTSGGNAAPLDLSFFDSHVPTPASTAQVDVAQPESPVTPVTPVTPGFTSTSPDETSNGNDPWAV 128

Human   111 WSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDT-AFGHPQAYQGP-----------ATGDDD 163
            :..:.||.:  |..|.|||||....:.:|. |.|.: ..|||||||||           :..:||
Zfish   129 FDNNASGGF--SNNWAAQPEGTETGKTSNN-NAWQSGGHGHPQAYQGPDIYPYPCLIDLSGAEDD 190

Human   164 DWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKP 228
            :|||:||..|||..:.:||:.:.|...||.  |..|||||.|||||||:|.|.|.|||:||..|
Zfish   191 EWDEEWDDMKSSGGYAESEAGEGGAMNRGG--AHGSSMKIALNKFPGFSKSGPELYLLSKQQTK- 252

Human   229 KEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWL 293
            ..|:.:..|:.||:|.||....|||||||:|||||||||||||||:.||.||:.|||||||||||
Zfish   253 GNKLSVYSGEVGPVWAYPDYQLDCVVADPKKGSKMYGLKSYIEYQVIPTTTNKPVNHRYKHFDWL 317

Human   294 YERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRD 358
            |||||.|||||||||.|||||||||||||||||||||||.||:|||||||:|.|||||.||:::|
Zfish   318 YERLLDKFGSAIPIPCLPDKQVTGRFEEEFIKMRMERLQGWMSRMCRHPVVSSSEVFQLFLSYKD 382

Human   359 EKEWKTGKRKAERDELAGVMIFSTMEPEA-PDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQE 422
            ||:|||||||||:||..|||||||:|||. ||:||:|:|||||...:||||||||||:|||||.|
Zfish   383 EKDWKTGKRKAEKDETVGVMIFSTIEPEGLPDMDLIEVEQKCEQFSRFTKAMDDGVKDLLTVGNE 447

Human   423 HWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLH 487
            ||||||||||||||:||||.|:|::||::|||:||..|.||:|.|||||||||.:||||||||||
Zfish   448 HWKRCTGPLPKEYQRIGKAFQNLSSVFTTSGYEGEGTLTDAMTAAGKTYEEIAQMVAEQPKKDLH 512

Human   488 FLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMSYALQAEM 552
            ||||.|:||||.||||||.||.||.|||||||:||||...|||..||..|.||.|.|||||||||
Zfish   513 FLMETNNEYKGLLGCFPDTIGVHKAAIEKVKEADKLVTAGKITASDKTTMGKRASTMSYALQAEM 577

Human   553 NHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM 595
            ||||:|||||||.|::.||||||:|||.||||||||.|:|..|
Zfish   578 NHFHNNRIYDYNRVMQQYLEQQVKFYEMIAEKLRQAHSQFTTM 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX9	NP_057308.1	SH3_SNX9	4..60	CDD:212831	40/55 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..201		43/137 (31%)
		Critical for tubulation activity	201..213		10/11 (91%)
		PX_SNX9	250..375	CDD:132818	105/124 (85%)
		BAR_SNX9	386..595	CDD:153352	156/209 (75%)
snx9b	XP_021324123.1	SH3_SNX9	4..60	CDD:212831	41/57 (72%)
		PX_SNX9	274..399	CDD:132818	105/124 (85%)
		BAR_SNX9	411..620	CDD:153352	155/208 (75%)