Protein Alignment SNX9 and SH3PX1

DIOPT Version :10

• Sequence 1: NP_057308.1
• Gene: SNX9 / 51429
• HGNCID: 14973
• Length: 595
• Species: Homo sapiens
• Sequence 2: NP_648348.1
• Gene: SH3PX1 / 39136
• FlyBaseID: FBgn0040475
• Length: 565
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 209/628 - (33%)
• Similarity: 313/628 - (49%)
• Gaps: 108/628 - (17%)

Human     1 MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGK 65
            |.:..|.||||..|||::||::..|:::::|..|||.||.||:|.:|:.||.|..|||::
  Fly     1 MTSYVRAMYDFTGEPGSSELSIATGDVLSVTRSDVGEGWWEGKNARGQIGLFPAAYVEVM----- 60

Human    66 DQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPE 130
                                |.|:|...:||....|....||:::....:.......:|
  Fly    61 --------------------SAAEAQKLSASGATSVPQVPDPFASPPLPRYDQTADDDG------ 99

Human   131 GAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWD--------GPKSSSYFKDSESADAG 187
                       :|||               |:|||.:|.|        |.||:     .:||.||
  Fly   100 -----------SNWD---------------DEDDWSDDNDTYSEIGPGGQKSA-----GQSARAG 133

Human   188 GAQRGNSRASSSSMKIPLN-------------------KFPGFAKPGTEQYLLAKQLAKPKEKIP 233
            |.....|...:..:.|..|                   |...||| .::.|:|.  |:..|||||
  Fly   134 GLSHSTSDYDNKHLPIAPNDDTQSLASVAGGTGAAGTVKKGMFAK-SSDSYILG--LSSTKEKIP 195

Human   234 -------IIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFD 291
                   ..|.|....|....|.:..|||.|:|.||..|:|::|.|||||:..|.||:.||||||
  Fly   196 ECEMAYITQVEDSIYQWTQNHSPYSVVVASPKKESKFKGMKTFIAYQLTPSFNNISVSRRYKHFD 260

Human   292 WLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNF 356
            ||:|||:.|| ..||:|.|||||::||:||:|::.|..:||.::..:|||||||:.||:..||..
  Fly   261 WLHERLVDKF-CLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDWVCRHPVISKCEVWYHFLTC 324

Human   357 RDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLV--EIEQKCEAVGKFTKAMDDGVKELLTV 419
            ||||.||:||||||||...||.....:.|  ||.:|:  :::.:.|...:|..:||..|:.|..:
  Fly   325 RDEKIWKSGKRKAERDPYMGVNYCLAISP--PDKNLLHSKVDAQVELGTQFIHSMDVAVRNLNNI 387

Human   420 GQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGET----DLNDAITEAGKTYEEIASLVAE 480
            ..:..||......||:|:||..|..||...:....:..|    .|::::...|..:..|.....:
  Fly   388 SNDMAKRSMSQSKKEFQRIGDGLSDLAKALAIDERRAPTRNAVPLSESVGRIGGIFIGIGQAFGD 452

Human   481 QPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMS 545
            |||.|...|.:..|.|:|.|.|||||..||||||:|.|:.:||....::......::.:|..::|
  Fly   453 QPKHDWIPLSDRLHIYRGVLNCFPDIFSTHKGAIQKRKDCEKLAGEGRMNNPQLHDVNRRTDVVS 517

Human   546 YALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQA 588
            |.:.||:.||.|.|.......::.::.:|::||:.:..:|::|
  Fly   518 YTVLAELTHFKSERDTHLKHTLKNFIAEQIKFYQGVVARLQEA 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX9	NP_057308.1	SH3_SNX9	4..60	CDD:212831	27/55 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..201		24/117 (21%)
		Critical for tubulation activity	201..213		4/30 (13%)
		PX_SNX9	250..375	CDD:132818	72/124 (58%)
		BAR_SNX9	386..595	CDD:153352	61/209 (29%)
SH3PX1	NP_648348.1	SH3_SNX9_like	4..59	CDD:212697	26/54 (48%)
		PX_SNX9_18_like	219..343	CDD:132772	72/124 (58%)
		BAR_SNX9_like	362..564	CDD:153310	58/199 (29%)