Protein Alignment PRKAG2 and Prkag2

DIOPT Version :10

• Sequence 1: NP_001393950.1
• Gene: PRKAG2 / 51422
• HGNCID: 9386
• Length: 619
• Species: Homo sapiens
• Sequence 2: XP_006535674.1
• Gene: Prkag2 / 108099
• MGIID: 1336153
• Length: 567
• Species: Mus musculus
• Alignment Length: 560
• Identity: 524/560 - (93%)
• Similarity: 538/560 - (96%)
• Gaps: 2/560 - (0%)

Human     1 MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDS 65
            ||||.|||||||:|||||||.||||.|.|||||||||||||||||||||||:|.|.|||||||||
Mouse     1 MGSAAMDTKKKKEVSSPGGSSGKKNPSLKRRSLRVHIPDLSSFAMPLLDGDVENSEKHSSRKVDS 65

Human    66 PFGPGSPSKGFFSRGPQPRPSSPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSS 130
            ||..||||:|.||||||||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse    66 PFSSGSPSRGLFSRGPQPRPSSPVSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSS 130

Human   131 SKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASS 195
            ||||||||||:||||||||||||||||.:||||||||||||||.|||||||.||||.|:||||||
Mouse   131 SKESSPNSNPSTSPGGIRFFSRSRKTSSVSSSPSTPTQVTKQHPFPLESYKQEPERPESRIYASS 195

Human   196 SPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEAVEDSESGV 260
            |||||||||| .:||||.||||||||::||.:.|.||||.|||||||||||||::|| |||||||
Mouse   196 SPPDTGQRFC-LAFQSPARPPLASPTYHAPLRTAVLAAAPGPAEAGMLEKLEFQEEA-EDSESGV 258

Human   261 YMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFIN 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   259 YMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFIN 323

Human   326 ILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDP 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   324 ILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDP 388

Human   391 ISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVER 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   389 ISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVER 453

Human   456 RISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETI 520
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||.||||
Mouse   454 RISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCSKLETLETI 518

Human   521 VDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAG 560
            ||||||||||||||||||||||||||||||||||||||||
Mouse   519 VDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAG 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAG2	NP_001393950.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..222		196/220 (89%)
		PHA03307	46..>221	CDD:223039	155/174 (89%)
		CBS_euAMPK_gamma-like_repeat1	269..406	CDD:341388	136/136 (100%)
		CBS repeat	277..350	CDD:341388	72/72 (100%)
		CBS repeat	362..406	CDD:341388	43/43 (100%)
		AMPK pseudosubstrate	370..391		20/20 (100%)
		CBS_euAMPK_gamma-like_repeat2	432..555	CDD:341399	120/122 (98%)
		CBS repeat	433..498	CDD:341399	64/64 (100%)
		CBS repeat	509..552	CDD:341399	40/42 (95%)
Prkag2	XP_006535674.1	CBS_euAMPK_gamma-like_repeat1	267..404	CDD:341388	136/136 (100%)
		CBS repeat	275..348	CDD:341388	72/72 (100%)
		CBS repeat	360..404	CDD:341388	43/43 (100%)
		CBS_euAMPK_gamma-like_repeat2	430..553	CDD:341399	120/122 (98%)
		CBS repeat	431..496	CDD:341399	64/64 (100%)
		CBS repeat	507..550	CDD:341399	40/42 (95%)