DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACTL6B and ARP4

DIOPT Version :9

Sequence 1:	NP_057272.1	Gene:	ACTL6B / 51412	HGNCID:	160	Length:	426	Species:	Homo sapiens
Sequence 2:	NP_012454.1	Gene:	ARP4 / 853364	SGDID:	S000003617	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	505	Identity:	135/505 - (26%)
Similarity:	227/505 - (44%)	Gaps:	116/505 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     5 VYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDT 69
            |||||||.|:|.|.||::...||:|.|.|::..|:..|...|:||           ..|||  ..
Yeast     8 VYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEG-----------NKKIF--SE 59

Human    70 NALHVPRDGAEVMSPLKNGMIEDWECFR-----AILDHTYSKHVKSEPNLHPVLMSEAPWNTRAK 129
            .::.:||...|:...::||::.||:..:     |:.:..|   :.|...: |.|::|..||:...
Yeast    60 QSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELY---LNSNSGI-PALLTEPVWNSTEN 120

Human   130 REKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPL 194
            |:|..|::.|.....|.:|..|:...:||.||...||:|.|....:..|:.||..|.:...::.:
Yeast   121 RKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFI 185

Human   195 AGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYM-------- 251
            ||.||:...::..:..  :|||.:.|..::       |.:.||....:|.||.::|.
Yeast   186 AGKFINHLIKKALEPK--EIIPLFAIKQRK-------PEFIKKTFDYEVDKSLYDYANNRGFFQE 241

Human   252 CNEVI-------------QDFQASVLQVSDSPYDEQVA----------------------AQMPT 281
            |.|.:             .:..::..:..:||::|::.                      |..|.
Yeast   242 CKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPR 306

Human   282 VHYEMPNGYNTDYGAERLRIPEGL----------------------------FDPSNVKG----- 313
            .:..:...:..||...:...|.|:                            .|..|..|
Yeast   307 SNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLE 371

Human   314 -----LSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSM 373
                 ...|.::|:..:|.:||...|:|:|..|..:|::|||.:.:.|.:|||..||: |..||:
Yeast   372 EEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELN-KILPSL 435

Human   374 RLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVER 423
            :.:::.:..|:||::..|:|||||.|||||.|:|:.|:||||.|   |||
Yeast   436 KFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVG---VER 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACTL6B	NP_057272.1	Actin	11..426	CDD:394979	129/499 (26%)
ACTL6B	NP_057272.1	Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250\|UniProtKB:Q99MR0	39..82		10/42 (24%)
ARP4	NP_012454.1	COG5277	9..488	CDD:227602	134/504 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81844
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55702
OrthoFinder	1	1.000	-	-		FOG0001878
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102754
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.870