Protein Alignment ACTL6B and Act79B

DIOPT Version :10

• Sequence 1: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_524210.1
• Gene: Act79B / 40444
• FlyBaseID: FBgn0000045
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 428
• Identity: 155/428 - (36%)
• Similarity: 228/428 - (53%)
• Gaps: 67/428 - (15%)

Human     9 DEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKE---------KKGKI 64
            :|..|||.|.||...:||:||:|.|:|.||:.||  .....|.:...|.|:         |:|.:
  Fly     4 EEASALVVDNGSGMCKAGFAGDDAPRAVFPSIVG--RPRHQGVMVGMGQKDCYVGDEAQSKRGIL 66

Human    65 FHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAK 129
                           .:..|:::|:|.:|:....:..||:...::..|..||||::|||.|.:|.
  Fly    67 ---------------SLKYPIEHGIITNWDDMEKVWHHTFYNELRVAPEEHPVLLTEAPLNPKAN 116

Human   130 REKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDS--GATHTTAIPVHDGYVLQQGIVKS 192
            |||:|::|||.:|.||.::...|||:.:|:||:||:||||  |.:||  :|:::||.|...|::.
  Fly   117 REKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT--VPIYEGYALPHAILRL 179

Human   193 PLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQ 257
            .|||..::....::..|......   ..|.:|.||:       .||||..|:            .
  Fly   180 DLAGRDLTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKLCYVA------------L 222

Human   258 DFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGV 322
            ||:..:...:.|...|:        .||:|:|.....|.||.|.||.||.||    ..|....|:
  Fly   223 DFEQEMATAAASTSLEK--------SYELPDGQVITIGNERFRTPEALFQPS----FLGMESCGI 275

Human   323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERK 387
            ...|..||..||:|||..||.:.:::||.|:..|..||:.:|::...|.::::|:||   ..|||
  Fly   276 HETVYQSIMKCDVDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIA---PPERK 337

Human   388 FSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 425
            :|.||||||||||.||||||||||||:|.|...|.|||
  Fly   338 YSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKC 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTL6B	NP_057272.1	ASKHA_NBD_Arp4_ACTL6-like	8..417	CDD:466846	150/418 (36%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		7/51 (14%)
Act79B	NP_524210.1	ASKHA_NBD_actin	7..371	CDD:466823	150/419 (36%)