Protein Alignment ACTL6B and Arp3

DIOPT Version :10

• Sequence 1: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_523968.1
• Gene: Arp3 / 38898
• FlyBaseID: FBgn0262716
• Length: 418
• Species: Drosophila melanogaster
• Alignment Length: 447
• Identity: 116/447 - (25%)
• Similarity: 195/447 - (43%)
• Gaps: 91/447 - (20%)

Human    13 ALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPR- 76
            |.|.|:|:...:.|:||...|:...|:.:.:..:...|                 |||...:.:
  Fly     7 ACVIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVG-----------------DTNTRRITKG 54

Human    77 ---------------DGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNT 126
                           .|..:..|:::|::|||:.....|:....|::::||..|..|::|.|.||
  Fly    55 IEDLDFFIGDEAFDATGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNT 119

Human   127 RAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRS--------TGLVLDSGATHTTAIPVHDGY 183
            ...||...|:|||.:|:|..::...|||...|:..|        ||:|:|||...|..|||.:||
  Fly   120 PENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGY 184

Human   184 VLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWH 248
            |:...|...|:||..|:...:.|.:|..:.|.|...:...:.:          |||        |
  Fly   185 VIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAI----------KEK--------H 231

Human   249 NYMCNEVIQDFQASVLQVSDSPYDEQVA---AQMPTVHYEMPNGYNTDYGAERLRIPEGLFDP-- 308
            .|:|.::.::|         :.||.:..   .....|:......:|.|.|.||...||..|.|
  Fly   232 CYICPDIAKEF---------AKYDTEPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEF 287

Human   309 SNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSM 373
            ||     .:..:.:..:|...|..|.||:|..||.:::::||:|:.:.|..||.|::.:.....:
  Fly   288 SN-----PDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRL 347

Human   374 RLKLIASNSTME-------------RKFSPWIGGSILASLGTFQQMWISKQEYEEGG 417
            |:....|...::             ::::.|.|||:|||...|.|:..:|..|||.|
  Fly   348 RISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKAAYEEYG 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTL6B	NP_057272.1	ASKHA_NBD_Arp4_ACTL6-like	8..417	CDD:466846	115/445 (26%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		5/58 (9%)
Arp3	NP_523968.1	ASKHA_NBD_Arp3-like	7..410	CDD:466822	116/447 (26%)