Protein Alignment ACTL6B and Act57B

DIOPT Version :10

• Sequence 1: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_523800.1
• Gene: Act57B / 37368
• FlyBaseID: FBgn0000044
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 428
• Identity: 159/428 - (37%)
• Similarity: 230/428 - (53%)
• Gaps: 67/428 - (15%)

Human     9 DEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALH 73
            |||.|||.|.||...:||:||:|.|:|.||:.||  .....|.:...|.|:.            :
  Fly     4 DEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVG--RPRHQGVMVGMGQKDS------------Y 54

Human    74 VPRDGAEVMS---------PLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAK 129
            |   |.|..|         |:::|:|.:|:....|..||:...::..|..||||::|||.|.:|.
  Fly    55 V---GDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKAN 116

Human   130 REKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDS--GATHTTAIPVHDGYVLQQGIVKS 192
            |||:|::|||.:|.||.::...|||:.:|:||:||:||||  |.:||  :|:::||.|...|::.
  Fly   117 REKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT--VPIYEGYALPHAILRL 179

Human   193 PLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQ 257
            .|||..::....::..|......   ..|.:|.||:       .||||..|:            .
  Fly   180 DLAGRDLTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKLCYVA------------L 222

Human   258 DFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGV 322
            ||:..:...:.|...|:        .||:|:|.....|.||.|.||.||.||    ..|....|:
  Fly   223 DFEQEMATAAASTSLEK--------SYELPDGQVITIGNERFRCPESLFQPS----FLGMESCGI 275

Human   323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERK 387
            ...|..||..||:|||..||.:::::||.|:..|..||:.:|::...|.::::|:||   ..|||
  Fly   276 HETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITSLAPSTIKIKIIA---PPERK 337

Human   388 FSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 425
            :|.||||||||||.|||||||||:||:|.|...|.|||
  Fly   338 YSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKC 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTL6B	NP_057272.1	ASKHA_NBD_Arp4_ACTL6-like	8..417	CDD:466846	154/418 (37%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		8/42 (19%)
Act57B	NP_523800.1	ASKHA_NBD_actin	7..371	CDD:466823	152/419 (36%)