Protein Alignment ACTL6B and Arp6

DIOPT Version :10

• Sequence 1: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_511165.1
• Gene: Arp6 / 32514
• FlyBaseID: FBgn0011741
• Length: 398
• Species: Drosophila melanogaster
• Alignment Length: 434
• Identity: 91/434 - (20%)
• Similarity: 188/434 - (43%)
• Gaps: 64/434 - (14%)

Human    14 LVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRDG 78
            :|.|.|:.:.:.|.|.:|.|.. .|..:  :.|:........|::..:.:    ||:||:
  Fly     6 VVLDNGAHTAKVGLANQDEPHV-VPNCI--MKAKSERRRAFVGNQIDECR----DTSALY----- 58

Human    79 AEVMSPLKNGMIEDWECFRAILDHTYSKH-VKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYN 142
              .:...:.|.:.:|...:.:.|:.:||. :........::::|...|.::.:|...|::||:|.
  Fly    59 --YILAFQRGYLLNWHTQKTVWDYIFSKDGIGCSLENRNIVITEPQMNFQSIQEATLEILFEEYK 121

Human   143 IPAFFLCKTAVLTAF-----ANGRST-----GLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGD 197
            :...:....|.|.||     :..|:|     .:::|.|.:.|..:|...|..:.|||.:..:.|.
  Fly   122 VDGVYKTTAADLAAFNYVADSEERTTMESLNCIIIDVGYSFTHVVPFVLGRRVLQGIRRIDMGGK 186

Human   198 FISMQCRELFQEMAIDIIPPYMIA--AKEPV-------REGAPPNWKKKEKLPQVSKSWHNYMCN 253
            .::.|.:||.....::::....:.  .||.|       ::....:: .:||..:|:..:
  Fly   187 ALTNQLKELISYRHLNVMDESHVVNQIKEDVCFVAEDFKQAMQVHY-SEEKRREVTVDY------ 244

Human   254 EVIQDF---QASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLS 315
             |:.||   :...::|...|.:::...||.::            ..||..:||.||:||::
  Fly   245 -VLPDFTTVKRGYVRVPGKPREDEEQQQMVSL------------CNERFTVPELLFNPSDI---- 292

Human   316 GNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIAS 380
            |...:|:...|...:..|..:....|..::::.||:....||..||.|:|....|..:.:.||..
  Fly   293 GVQQVGIPEAVADCLKACPWEAHRELLLNILIVGGSAQFPGFLPRLKRDLRALVPDDLEVSLICP 357

Human   381 NSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERK 424
            ...:.   ..|.||..:|:...|::...::.:|||.|.|.:.::
  Fly   358 EDPVR---YAWYGGKEVATSPNFEEFVYTQDDYEEYGFQGINQR 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTL6B	NP_057272.1	ASKHA_NBD_Arp4_ACTL6-like	8..417	CDD:466846	89/425 (21%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		6/42 (14%)
Arp6	NP_511165.1	ASKHA_NBD_Arp6	5..391	CDD:466816	89/425 (21%)