DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDE4A and Pde11

DIOPT Version :9

Sequence 1:NP_001104777.1 Gene:PDE4A / 5141 HGNCID:8780 Length:886 Species:Homo sapiens
Sequence 2:NP_001286044.1 Gene:Pde11 / 35107 FlyBaseID:FBgn0085370 Length:1451 Species:Drosophila melanogaster


Alignment Length:1044 Identity:202/1044 - (19%)
Similarity:349/1044 - (33%) Gaps:355/1044 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    88 SSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDS 152
            ||...|| |:.||||            .||.|.|              |.|.:..:..:.:    
  Fly   352 SSLGSTG-GASGAGG------------APSLGGS--------------GGAGNGHQYPYYH---- 385

Human   153 DYDMSPKTMSRNSSVTSEAHAEDLI------VTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPL 211
             ....|:.:|||.  ..:...::||      :....:|......:..|.|:|.|.     .|..|
  Fly   386 -CHQRPQRLSRNE--LKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNA-----DRGSL 442

Human   212 -------GGPTPVCKATLSE--ETCQQLARETLEELD-----W---------------------- 240
                   .||..:.|..:|:  :.|.:...|.:|:.|     |                      
  Fly   443 FLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507

Human   241 -----CLEQLETMQTYRS-----------------------------VSEMASHKFKRML----- 266
                 |  :::::..||:                             .||:....|...|     
  Fly   508 DERFNC--EIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGI 570

Human   267 ---NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE----------------------------- 299
               |.:|...|::....|||...::....::|:.:|                             
  Fly   571 GLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADK 635

Human   300 --------IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS-NIP-- 353
                    ..:..:.|.|......|..|:.|        ....|||     |..:...: |:|  
  Fly   636 GSFSRVFDFEANDLSEEEATSRTSPYESRFP--------INIGITG-----HVATTGETVNVPNA 687

Human   354 ----RFGVKTDQ------EELLAQELEN-----------LNKW--------------GLNIFC-- 381
                ||....|:      ..:|...::|           :||:              ...|||  
  Fly   688 YEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGM 752

Human   382 -----------------------VSDYAGGRSL-------------------------------- 391
                                   |..|....::                                
  Fly   753 GIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDD 817

Human   392 ----TCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATP 452
                .|:  .:|.:.|.:::|.|..:.:..::|:::.:|. :|.|||..||.:|.|....:|.|.
  Fly   818 DTLKACL--RMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTT 879

Human   453 ALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 517
            ....:|.::|.||.:.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|...
  Fly   880 QWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSP 943

Human   518 NCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV 582
            ...|..|||......:.:::.|.:|:||::.:.......  :....:.||..|.     .:...:
  Fly   944 GNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRAL 1001

Human   583 LR--NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISP---MCDKHTASVEKSQ 642
            ||  :|..| |||..|||.|:.::..|.:.:|||:|||.|::. :.|:|   |..:....:...|
  Fly  1002 LRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQ 1064

Human   643 VGFIDYIVHPLWETWADLVHPDAQEILDTLEDNR-DWYYSA----IRQSPSPPPEEESRGPGHPP 702
            |.|||.|..|::|.:|.| ....:.:::.:.||| .|...|    .:.|....|||         
  Fly  1065 VNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEE--------- 1119

Human   703 LPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALD----------ATIAWEASPA 757
                       |::::..||.......:.:.:.|   |..|.|:|          :.:|..:|..
  Fly  1120 -----------EQQQQNVISNGDCKAMSDDDVAA---SEAEVAVDSPSEKASVNGSNVANNSSNT 1170

Human   758 QESLEVMAQEASL-------EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSS----- 810
            .:.:.|.:...|.       :.:.:|..:.:||..........||.|.|.....:.|.:|     
  Fly  1171 NKKIAVASHPTSTQPSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTASSCLST 1235

Human   811 --PSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSAC----AGTFGED 869
              |:.....:|:.|. :||.....|..|     .|.:.:...:.|..|:.|.:|    :|.....
  Fly  1236 PPPTGEDDSTPVSPL-KTLQAKLVAANL-----NALQRQTSNQAQTQKQRCKSCDHSRSGLQVRK 1294

Human   870 TSAL 873
            ||:|
  Fly  1295 TSSL 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDE4ANP_001104777.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..128 13/39 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..331 7/73 (10%)
PDEase_I 432..673 CDD:278654 73/245 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 682..705 5/26 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 866..886 3/8 (38%)
Pde11NP_001286044.1 GAF 420..582 CDD:214500 25/168 (15%)
GAF 611..762 CDD:214500 21/163 (13%)
PDEase_I 859..1094 CDD:278654 73/245 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154158
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D904682at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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