Protein Alignment EIF3L and eIF3l

DIOPT Version :10

• Sequence 1: NP_057175.1
• Gene: EIF3L / 51386
• HGNCID: 18138
• Length: 564
• Species: Homo sapiens
• Sequence 2: NP_648553.1
• Gene: eIF3l / 39386
• FlyBaseID: FBgn0036258
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 301/569 - (52%)
• Similarity: 398/569 - (69%)
• Gaps: 44/569 - (7%)

Human     3 YPADDYESEA-AYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQV-IPEVIKNFIQYFHKTVSD 65
            |..|:|.:.: .||.||       |||||:.|:.|||.|    |.. :|:.:|.|:..|.:.:.
  Fly     2 YGGDEYATNSDYYDDYA-------HTGDPQLDMEYERNY----YAARMPDNVKYFLINFCQAIK- 54

Human    66 LIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLI 130
                               :..:|:||::|||::.::::..|..|.|||.:.:|..|.||.||||
  Fly    55 -------------------EGNLYDIQNMYENTFPQISDHHFDKTAWPEEQEVAAIVDNDKVFLI 100

Human   131 LYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQ 195
            ||||||||||:|::.|||.||||..|::|||:.||.|::|..|..||||:.|||:::|||:||||
  Fly   101 LYKELYYRHIHARIPGGPKLEQRINSFFNYCDFFNLIISAQNPVMLELPDIWLWELVDEFVYQFQ 165

Human   196 SFSQYRCKTAKKSEEEIDFL---RSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVA 257
            :|:|||.:..:||::||..|   .||.  |::..:|||||||||.|||.:|||..:.|.||::||
  Fly   166 NFAQYRARLTEKSQDEIQQLCVNHSNE--WSILCILNVLHSLVDISNIKKQLEAISQGVDPQTVA 228

Human   258 GEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFA 322
            |::|:.|.||||||||||||||:|||||||||||||||.||::|||.||.:|.||::|.||||||
  Fly   229 GDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFA 293

Human   323 YLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIH 387
            |:|||||.||||.|::|||||||||.::...:|:.:.||||.|||:.||||.|.::|..|||||.
  Fly   294 YMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQ 358

Human   388 LQLREK-YGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEV 451
            ..|||| |.|.|.:||.||.:|::..|.::||:|:||..|..|....:|.|:|...||:||.|||
  Fly   359 QVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAVDAPMDDYVKDPMEHQLQVFMDEV 423

Human   452 QQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQE-----FRIQLLVFKHKMKNLVWTSGISALDG 511
            :||..|.|.||:||||||:|:.|||.|:|....|     ..|:||.|||||:||||:.|.|.|:|
  Fly   424 RQQKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEG 488

Human   512 EFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKM 560
            .|:|.||:|||||.||||||||||:.||||||:|:|.||.:|||.||.:
  Fly   489 TFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKILKFNDLNRKLKNI 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF3L	NP_057175.1	Paf67	152..550	CDD:463028	237/406 (58%)
eIF3l	NP_648553.1	Paf67	122..527	CDD:463028	237/406 (58%)