Protein Alignment CSAD and b

DIOPT Version :9

• Sequence 1: XP_024304779.1
• Gene: CSAD / 51380
• HGNCID: 18966
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_001246025.1
• Gene: b / 34791
• FlyBaseID: FBgn0000153
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 263/604 - (43%)
• Similarity: 364/604 - (60%)
• Gaps: 61/604 - (10%)

Human    39 HFTEAARLGWRKAQGPSLGASVAGRNGTGSAHTCAFSPSARRSYLCTLPPALL-----------S 92
            ||.|:....:....|..| |||:....|.:......||:...|.:.....:.:           :
  Fly    11 HFKESIFKPYSTTSGDDL-ASVSPLTATAALVASTSSPADSTSTVAFEQASKMLANAANNNNNNN 74

Human    93 REILMADSEALPSLAGDPVA-VEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLEL 156
            ..|.....:....:|..|.| .|..:||....::..|:.:||:.|.||.||.||.||:||.|.:|
  Fly    75 NNITSTKDDLSSFVASHPAAEFEGFIRACVDEIIKLAVFQGTNRSSKVVEWHEPAELRQLFDFQL 139

Human   157 RSQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFV 221
            |.|||||.::.|..|..||:|||||||.|.|||:||:||:||.|:.:|::||.|.||||:||:|.
  Fly   140 REQGESQDKLRELLRETIRFSVKTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFT 204

Human   222 LMEEEVLRKLRALVGW---SSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALFTS 283
            ||||:||.::|.:||:   ..|||||||||||:|.||::.|||:..|:.|:.||....||.:|||
  Fly   205 LMEEQVLAEMRRIVGFPNGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNGLFNAKPLIIFTS 269

Human   284 KEVGKRHRPNPGLLILI---SSHVTTPSRRE---LRFWDLAPTVSEWSRLMREGKWSPRIWRGRL 342
            ::.   |.....|.:.:   |.||...:..|   :|..||...|    :|..|..|.
  Fly   270 EDA---HYSVEKLAMFMGFGSDHVRKIATNEVGKMRLSDLEKQV----KLCLENGWQ-------- 319

Human   343 VWPRLRLTFHFFETFILDSGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSV 407
                                  |.:||||:|||||||||.|..|::||:::.:|:||||||||..
  Fly   320 ----------------------PLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGA 362

Human   408 LLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDV 472
            |:|:.:||||:||:|||||.|||||||||..|||..|.:. ..:|.:||.:.|:||||:|||||.
  Fly   363 LMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRH-QQVLAQCHSTNATYLFQKDKFYDT 426

Human   473 ALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVME-PEF 536
            :.|||||.:|||||.|..|.|.||||:|.||||..:::.|.:|.:...::::|.|||||:| ||.
  Fly   427 SFDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLESPEC 491

Human   537 VNVCFWFVPPSLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSAL 601
            .|:.||:|||.||..:.:.::::||.||||.:||.|:|:|||||.|||.....||||:|:.||.|
  Fly   492 TNISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFRLVLQNSCL 556

Human   602 TCADMDFLLNELERLGQDL 620
            ..:||.:.|:|:|.|.|:|
  Fly   557 EESDMVYFLDEIESLAQNL 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSAD	XP_024304779.1	DOPA_deC_like	185..616	CDD:99743	208/440 (47%)
b	NP_001246025.1	AAT_I	128..499	CDD:302748	196/408 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160392
Domainoid	1	1.000	435	1.000	Domainoid score	I578
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1214
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S2959
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm42070
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45677
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5043
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.940