Protein Alignment CSAD and Tdc2

DIOPT Version :10

• Sequence 1: XP_054228176.1
• Gene: CSAD / 51380
• HGNCID: 18966
• Length: 652
• Species: Homo sapiens
• Sequence 2: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 131/562 - (23%)
• Similarity: 207/562 - (36%)
• Gaps: 141/562 - (25%)

Human   130 QKGTSVSQKVCEW------------KEPEELKQLLDLELRSQGESQKQILERCRAVIRYSV-KTG 181
            ::|..:.:.:|.:            .||..|:.||..|...:.|...||:......|...| ...
  Fly     8 KRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIMPGVTHWQ 72

Human   182 HPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVG---------- 236
            ||||.....:|....::.|.::.:.:....:::..:|....:|..||..|...:|
  Fly    73 HPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLALKE 137

Human   237 WSSGDGIFCPGGSISNMYAVNLARYQ-------RYPDCKQRGLRTLPPLALFTSKEVGKRHR--P 292
            .|:|.|:.....|...:..:..||.|       ::|..::..|  |..|..:.|||.   |.  .
  Fly   138 GSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHL--LSKLMAYCSKEA---HSCVE 197

Human   293 NPGLLILISSQLSRDLPGLLPALPTSSKASLPPGGCASFQSRSVTTPSRRELRFWDLAPTVSEWS 357
            ...::..:..::                  |.|...||.:.:::
  Fly   198 KAAMICFVKLRI------------------LEPDDDASLRGQTI--------------------- 223

Human   358 RLMREGKWSPRIWRGRLVWPRLRLTFHFFETFILD--SGAVPFLVSATSGTTVLGAFDPLEAIAD 420
                                        :|....|  .|.|||.||.|.|||...|||.|..|..
  Fly   224 ----------------------------YEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGK 260

Human   421 VCQRH-GLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQD----T 480
            ..||. |:|||||||:.|:..:....:.||.||:.|||...||:|.|.....||.|.::|    |
  Fly   261 QLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRIRLT 325

Human   481 SNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFV 545
            |.|:       ...|:.:..:.|.|:|.....|...||...||||.:.::.|..||:..|.....
  Fly   326 SALV-------VDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIK 383

Human   546 LARYLVEEMKKREGFELVMEPEFVNVCFWFVPPSLRGKQESPDYHERLSKVAPVLKERMVKEGSM 610
            ||:...|.:.|.:.||:..:.:...|||     .|:|   |...:|:|..:       :.:.|.:
  Fly   384 LAKRFEELVLKDKRFEICNQVKLGLVCF-----RLKG---SDKLNEKLLSI-------INESGKL 433

Human   611 MIGYQPHGTRGNFFRVVVANSALTCADMDF-------LLNEL 645
            .:.....|.|.......||.:| |..|:|:       ..|||
  Fly   434 HMVPASVGDRYIIRFCAVAQNA-TAEDIDYAWDIIVDFANEL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSAD	XP_054228176.1	DOPA_deC_like	185..648	CDD:99743	115/494 (23%)
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:395219	111/462 (24%)