Protein Alignment PDE2A and Pde8

DIOPT Version :10

• Sequence 1: NP_002590.1
• Gene: PDE2A / 5138
• HGNCID: 8777
• Length: 941
• Species: Homo sapiens
• Sequence 2: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Alignment Length: 1093
• Identity: 226/1093 - (20%)
• Similarity: 377/1093 - (34%)
• Gaps: 361/1093 - (33%)

Human    38 PPPQPCADSLQDALLSLGSV-IDISGLQRA-----------VKEALSAVLP--RVETVYTYLLDG 88
            |.|.|..||::..|:|...: :|: ||:.|           ::.......|  :|||:
  Fly    60 PRPLPDDDSIRSRLISAAHLDLDV-GLELASDSTAVPANGGIRPKSEGACPEMKVETI------- 116

Human    89 ESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGK------------------PLARL 135
               .....||...|..|......||...:|.|.   |..|.:                  ||.|.
  Fly   117 ---SAATSPPPPRPLHGTSGPVAISLPFVGRNS---SKTPEEMELEYEANVEAESRDIMTPLRRN 175

Human   136 VAPLA-------------PDTQVLVMPLADKEAGAVAAVILVHC---------GQLSDNEEWSLQ 178
            ..||:             |:....:..|      .|.|:.|.:.         |:.:..||..|.
  Fly   176 TRPLSVSFGGGGGRSALQPEIVEAIRSL------DVPALRLNNLSFDGSTDPKGERNHAEEEPLT 234

Human   179 AVEKH--TLVALRRVQVLQQRG----PREAPR---------AVQNPPEGTAEDQKGGAAYTDRDR 228
            ....|  ::|..|:|..|:::.    .|..||         ..:|||  |.|::     :....|
  Fly   235 PGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPP--TEEEE-----FRTFQR 292

Human   229 KILQL-------------------------------CGELYDLDASSLQLK--VLQYLQQETRAS 260
            .::.|                               | :.:.||.:.::.|  .|..||:....:
  Fly   293 NLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAAC-QRHQLDVTLVKSKEEALDTLQKSYATA 356

Human   261 RCCLLLV--SEDNLQLSCKVIGDKVL---GEEVSFPLTGCLGQVVE-DKKSIQLKDL-TSEDVQQ 318
            :|..|::  :..:..|..:.|...:.   |..::..:..|.....| |...|.|.|. .:..|.:
  Fly   357 QCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCVAE 421

Human   319 LQSMLGCELQAMLCVPVISR-----ATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLT 378
            ..::..|.::....:..|.|     :|.|  ||..|.::|:..:...:|...||:....|..:|.
  Fly   422 TTNLAMCSVELKQILHSIIRPHNVMSTQQ--ALYTALHRLKEVVLITDDLLRIQYANRATERLLN 484

Human   379 STL----AFQKEQKLKCECQALLQVAKNLF--------------------------------THL 407
            ..|    :.|.|.....:...:.:..||:.                                |||
  Fly   485 MRLDEIISKQLEDIFVSDLSTISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGSAPTHL 549

Human   408 -----------DDVSVL-----------------------------------------LQEIITE 420
                       |.::.|                                         |:..||:
  Fly   550 IFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLEAPITK 614

Human   421 ARNLSN--AEICSVFLLDQNELVAKVFD----GGVVDDESYEIRIPADQGIAGHVATTGQILNIP 479
            ..||.:  .|.||.   |:..|:.||.:    .|:...:..|||  .|..||..:  .|.:|..|
  Fly   615 IINLLSQVQENCSA---DEARLIDKVLEFLKREGLYSPQMKEIR--TDDPIATDL--IGALLTGP 672

Human   480 DAYAHPLFYRGVDDS---TGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFS 541
            ..|:.   .|..:||   ||..||.....|.|.::..:|  .||:           ||.|:..|.
  Fly   673 SVYSS---RRSSNDSIIRTGSSTRTAAIVPAKMKSNPII--MELL-----------DESLSWDFD 721

Human   542 IYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYT 606
            |:            |:.|                 ::|  |..||:.|::.....|. ||:...
  Fly   722 IF------------KLEE-----------------ITD--YHPLLYLGMEMFRRFDV-FATLNI- 753

Human   607 PRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSV-----SH 666
                 :::...|.|::::     .:|:                 :...|||..||..|     :.
  Fly   754 -----DENVCKAWLAVIE-----AHYR-----------------KSNTYHNSTHAADVMQATGAF 791

Human   667 FCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHF 731
            ...|..|::.:.:.:|  |..|| |:...||:||.|.:::|...|...||.|| ::.:|:|.||.
  Fly   792 ITQLTNKDMLVMDRME--EATAL-IAAAAHDVDHPGRSSAFLCNSNDALAVLY-NDLTVLENHHA 852

Human   732 AQAIAI-LNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQH 795
            |....: |.....|||.:..::.|:.....:.|:||||::..|   |:.|.|...|......:.|
  Fly   853 AITFKLTLGDDKINIFKNLDKETYKSARSTIIDMILATEMTRH---FEHLAKFVSVFGGEEPRDH 914

Human   796 HR--------LLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRP--MEMMDR 850
            :.        |:..:|:...|:|:..:..:...:.|..|.:|:|.|.|.|| ..:.|  |.|.||
  Fly   915 NPQTDEETSILMRRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEK-QRHLPIVMPMFDR 978

Human   851 EKAYIPELQISFMEHIAMPIYKLLQDL------FPKAAELYERVASNREHWTK 897
            ....||:.||.|:|:|       :||:      |....:|...:..|...|.|
  Fly   979 ATCSIPKSQIGFIEYI-------IQDMMHAWESFIDMPQLITYMQINYSQWKK 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE2A	NP_002590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..42		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..221		8/37 (22%)
		GAF	241..387	CDD:214500	33/163 (20%)
		GAF	409..558	CDD:214500	42/198 (21%)
		PDEase_I	655..888	CDD:459723	73/254 (29%)
Pde8	NP_001163275.2	NtrB	446..>539	CDD:443061	16/94 (17%)
		PDEase_I	775..1016	CDD:459723	73/255 (29%)