DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PDE2A and Pde11

DIOPT Version :9

Sequence 1:	NP_002590.1	Gene:	PDE2A / 5138	HGNCID:	8777	Length:	941	Species:	Homo sapiens
Sequence 2:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	246/762 - (32%)
Similarity:	390/762 - (51%)	Gaps:	69/762 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   230 ILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLV-----SEDNLQLSCKV----------- 278
            :..:|.|   |:..:|..|:||.:.....|.|..|.||     ..|.|: .|.|
  Fly   411 VKDICNE---LEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLK-KCLVSKLFDVCPRST 471

Human   279 IGDKVLGEEVSFPL-TGCLGQVVEDKKSIQLKDLTSED--VQQLQSMLGCELQAMLCVPVISRAT 340
            :.:....:||.... ||..|.|.|..:.:.:.|...::  ..::.|:.|...:|:||:|:...:.
  Fly   472 VEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSG 536

Human   341 DQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFT 405
            | |:.:|...||:.|:.|::.||.|......:....|.:...::|.|......|.||.:|:.:|.
  Fly   537 D-VIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFE 600

Human   406 HLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE--LVAKVFD---GGVVDDES------YEIRI 459
            ....:..::..|:|..::|...:...:.|:.:.:  ..::|||   ..:.::|:      ||.|.
  Fly   601 EQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRF 665

Human   460 PADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKI 524
            |.:.||.|||||||:.:|:|:||....|...||:::.|:.|:|||..|||...::|||.:|:||.
  Fly   666 PINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKF 730

Human   525 NGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDG 589
            |...|:|.||:...||:|:||:.|.::.:|:|...|..:..:..|::.||...:.||..:|..
  Fly   731 NELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRR-- 793

Human   590 IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPP 654
            ::..:|:......|.:......:|||..|.|.|..|::|:..:.||...|.|:.|.|||.||:..
  Fly   794 LRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVT 858

Human   655 YHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALY 719
            ||||.|||:|:...:.:....:......:||..||.|.|:||||||||||||||:.:.|.||.||
  Fly   859 YHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLY 923

Human   720 SSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKD----L 780
            |:  |.||.|||.|.:.|||:.|..|..:.|..||.|::.::.|.||:||||.:   ||.    |
  Fly   924 ST--STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVY---FKKRGPFL 983

Human   781 QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGN-RP 844
            :.:::.......::...||..:.||.||||..||.|:..:::|:|:..|||.|||:||...| .|
  Fly   984 ESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITP 1048

Human   845 MEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHW--------TKVS- 899
            :::|:|||. .:|.:|::|::.|.:|||:....|..|...|.|.|..||.||        ||.|
  Fly  1049 IDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQ 1113

Human   900 -----HKFTIRGLPSNNSL------DFLDEEYEVP-DLDGTRAPING 934
                 .:...:.:.||...      |....|.||. |....:|.:||
  Fly  1114 DQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNG 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDE2A	NP_002590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..221
		GAF	241..387	CDD:214500	39/164 (24%)
		GAF	409..558	CDD:214500	55/159 (35%)
		PDEase_I	655..885	CDD:306695	96/235 (41%)
		Substrate binding	656..660		3/3 (100%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	39/163 (24%)
		GAF	611..762	CDD:214500	54/150 (36%)
		PDEase_I	859..1094	CDD:278654	98/239 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750