Protein Alignment PDE2A and Pde1c

DIOPT Version :10

• Sequence 1: NP_002590.1
• Gene: PDE2A / 5138
• HGNCID: 8777
• Length: 941
• Species: Homo sapiens
• Sequence 2: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 132/502 - (26%)
• Similarity: 219/502 - (43%)
• Gaps: 81/502 - (16%)

Human   461 ADQGIAGHVATTGQILNIPDAYAH-------PLFYRGVDDSTGFRTRNILCFPIKNENQEVIGV- 517
            |.:..||...::|...|  .|..|       |.:.|.:..:   :||      :.:|:.|:..|
  Fly   621 AAESQAGSAGSSGSCSN--PAAVHRQRRLRTPTWARSMSTN---KTR------LADEDDELSEVQ 674

Human   518 AELVNKINGPWF-SKFDEDLATA---------FSIYCGISIAHSLLYKKVNEAQYRSHLANEMMM 572
            .:.|......|. |.|...:||:         |.     |:||::......:..||
  Fly   675 PDAVPPEVREWLASTFTRQMATSRRKSDEKPKFR-----SVAHAIRAGIFVDRMYR--------- 725

Human   573 YHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDM----NFINNYK 633
               :||....|....|    |..:..|...:|:...:|.|..:...:..:..::    ..|:.:|
  Fly   726 ---RVSSSALTAFPPD----VVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFK 783

Human   634 IDCPTLARFCLMVKKG---YRDPPYHNWMHAFSVS---HFCYLLYKNLELTNYLEDIEIFALFIS 692
            |....|..|...|::|   ||: ||||.:||..|.   |:|..   |..|.|:|.|:||||..::
  Fly   784 IAPGILEAFLHRVEEGYCRYRN-PYHNNLHAVDVMQTIHYCLC---NTGLMNWLTDLEIFASLLA 844

Human   693 CMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRM 757
            .:.||.:|.||.|:|.|.|.|..|.|| ::.:|:|.||.:.:..:|.....||..|.||::::.:
  Fly   845 ALLHDYEHTGTTNNFHVMSGSETALLY-NDRAVLENHHASASFRLLREDEYNILSHLSREEFREL 908

Human   758 LDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKI 822
            ..|:.:::|.||:.:|.:..|.::::..:.....:||.   :|.|::..||:|...|.|....:.
  Fly   909 RGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQK---VLSLVLHCCDISHPAKQWGVHHRW 970

Human   823 AELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQD-----LFPKAA 882
            ..|:.:|||.||||||.:|.....:.||....:.|.||.|::.|..|...::.|     |.|.|.
  Fly   971 TMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAP 1035

Human   883 ELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTR 929
            ....:.|:..||.|..:        .:.||...:......|.:|..|
  Fly  1036 MNKSKPATLVEHETTAN--------STTNSAIVIPNSGITPSMDKPR 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE2A	NP_002590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..42
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..221
		GAF	241..387	CDD:214500
		GAF	409..558	CDD:214500	24/114 (21%)
		PDEase_I	655..888	CDD:459723	78/240 (33%)
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	14/70 (20%)
		PDEase_I	807..1027	CDD:459723	75/226 (33%)