Protein Alignment PDE2A and Pde9

DIOPT Version :10

• Sequence 1: NP_002590.1
• Gene: PDE2A / 5138
• HGNCID: 8777
• Length: 941
• Species: Homo sapiens
• Sequence 2: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Alignment Length: 645
• Identity: 151/645 - (23%)
• Similarity: 250/645 - (38%)
• Gaps: 159/645 - (24%)

Human   351 NKLEGDL--FTDEDEH-----VIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLD 408
            |.||..|  |.:|.:|     ||:|..|.         ..|:.|:
  Fly   370 NLLEELLIQFYEEQDHRSNLTVIRHHHHQ---------QHQQHQQ-------------------- 405

Human   409 DVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAG-HVATT 472
                  |:.||...|.:|.  |: .:.:.|.:.............|.|  .||..|... |:..|
  Fly   406 ------QQRITNNNNNNNN--CN-SIQNNNNMSNPAATAAATATPSVE--QPATSGTTNIHLQPT 459

Human   473 GQILNIPDAYAHPLFYRGVDDST--GFRTRNILCFPIKNEN----------------QEVIGVAE 519
                ::||...:|...|..|.|.  ......:.|..:||.|                :.::....
  Fly   460 ----SLPDGSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANS 520

Human   520 LVNK---INGPWFSKFDED----LATAFSIYCGISI------------AHSLLYKKVNEA----- 560
            :.|:   |.....|..|.|    .|||.|...|..|            |..:....:|.|
  Fly   521 IANRATIILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIV 585

Human   561 ----------------QYR-SHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAID-SNFASFTYTP 607
                            :|. ..|.|.::..|.  :||::..|:.|..:.|...: .|:...:..|
  Fly   586 ASNNGNNGNNGNNGNNEYSILQLNNTIIQCHF--NDDDFRALVKDLKRKVEYTERMNWLCLSKRP 648

Human   608 -------RSLPED-----------DTSMA---------------------ILSMLQ----DMNFI 629
                   .|||:.           ||:.:                     ::.::|    ::.||
  Fly   649 LGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDADVIHLMQTMFVELGFI 713

Human   630 NNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCM 694
            ..:.|...||..:...|.|.|.:.|:||:.|.|.|:...|.:.:...|.:.|.|:|...|.:||:
  Fly   714 EKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCI 778

Human   695 CHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLD 759
            ||||||.|.||.:|:.:::.||..| ::.|.:|.||.:.|..:|....||||.:|||..:..:.:
  Fly   779 CHDLDHPGYNNIYQINARTELALRY-NDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIRE 842

Human   760 LMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE 824
            .:...|||||:|.|..|.....::..: :|.:|:.|..||..:|:...|:|::.:.........:
  Fly   843 GIIRCILATDMARHNEILTQFMEITPI-FDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLD 906

Human   825 LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAEL 884
            .:.:|||:|...||:.|......||.:|...|..|:.|:..:.:|:::.|.:|.|:..||
  Fly   907 RLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTEL 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE2A	NP_002590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..42
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..221
		GAF	241..387	CDD:214500	12/42 (29%)
		GAF	409..558	CDD:214500	36/186 (19%)
		PDEase_I	655..888	CDD:459723	74/230 (32%)
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	74/230 (32%)