Protein Alignment PDE2A and dnc

DIOPT Version :10

• Sequence 1: NP_002590.1
• Gene: PDE2A / 5138
• HGNCID: 8777
• Length: 941
• Species: Homo sapiens
• Sequence 2: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 995
• Identity: 208/995 - (20%)
• Similarity: 342/995 - (34%)
• Gaps: 293/995 - (29%)

Human     3 QACGHSILCRSQQYPAARPAEPR-------GQQVFLKPDEPPPPPQPCADSL---------QDAL 51
            |.|.    |:.|..|.....|..       ..|..||..:|.|||...|...         ..|.
  Fly   314 QRCS----CQPQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSAT 374

Human    52 LSLGSVIDISG--LQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHE-------LPQEGKV 107
            .|....:...|  .|..:....|...||::..:.             .||:       |...|..
  Fly   375 SSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFR-------------KPHKSCWSRIVLAPIGSA 426

Human   108 REAIISQKRLGCNG---LGFSDLPGKPLA--------------RLVAPLA--------PDTQVLV 147
            ..:..:...:|.|.   |..|...|....              ||.:..|        .::|:|.
  Fly   427 GGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLP 491

Human   148 MPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPRE-----APRA-- 205
            ......|.|::..:...|...|.:         .:|||..: |..|...:|.|.     :|.|
  Fly   492 TSKMQAEQGSIGDLQKYHSRYLKN---------RRHTLANV-RFDVENGQGARSPLEGGSPSAGL 546

Human   206 -VQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSE 269
             :||.|:              |....|......:::...|:           :|.|.    :.||
  Fly   547 VLQNLPQ--------------RRESFLYRSDSDFEMSPKSM-----------SRNSS----IASE 582

Human   270 DNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQ--LKDLTSEDVQQLQSMLGCELQAMLC 332
            ...:....::.|:..||::   :.....|::...:|::  |..||:
  Fly   583 RFKEQEASILVDRSHGEDL---IVTPFAQILASLRSVRNNLLSLTN------------------- 625

Human   333 VPVI--SRATDQVVALACAFNKLEGDLFTDEDEHV---------IQHCFHYTSTVLT----STLA 382
            ||..  ||..:|..:.:.:.|.....|...|:.:.         :..|.....|:.|    |.:|
  Fly   626 VPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMA 690

Human   383 FQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFD- 446
            ..|.:::         :.|.| :|..:.|        .:.|..:..|||.||..|.|     ||
  Fly   691 SLKFKRM---------LNKEL-SHFSESS--------RSGNQISEYICSTFLDKQQE-----FDL 732

Human   447 -GGVVDD--ESYEIRIPADQGIAGHVATT--------GQILNIPDAYAHPLFYRGVDDSTGFRTR 500
             ...|:|  |.......|.|..||..|.:        .||..:....:|         :..|...
  Fly   733 PSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSH---------TNSFTGE 788

Human   501 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSH 565
            .:..|.::...:..:|.  |:.::: .|                ||.| .|:....||
  Fly   789 RLPTFGVETPRENELGT--LLGELD-TW----------------GIQI-FSIGEFSVN------- 826

Human   566 LANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFIN 630
                                     :|:..:       .||               :.|....:.
  Fly   827 -------------------------RPLTCV-------AYT---------------IFQSRELLT 844

Human   631 NYKIDCPTLARFCLMVKKGY-RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEI-FALFISC 693
            :..|...|...|...::..| :|.|:||.:||..|:....:|.....|......:|: .|||.:|
  Fly   845 SLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAAC 909

Human   694 MCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRML 758
            : ||:||.|..|.|.|.|.|.||.:|:.| ||:|.||.|.|..:|...||:||.:..:|..|.:.
  Fly   910 I-HDVDHPGLTNQFLVNSSSELALMYNDE-SVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLR 972

Human   759 DLMRDIILATDLAHHLRIFKDLQKMAEV------------GYDRNNKQHHRLLLCLLMTSCDLSD 811
            .::.||:|:||::.|:.:..||:.|.|.            .|....:....|:.|     .|||:
  Fly   973 KMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHC-----ADLSN 1032

Human   812 QTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQD 876
            .||.....::...|:.:|||.|||.|:..|.....|.||..|.|.:.|:.|:::|..|:::...|
  Fly  1033 PTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWAD 1097

Human   877 L-FPKAAELYERVASNREHW 895
            | .|.|.::.:.:..||:::
  Fly  1098 LVHPDAQDILDTLEENRDYY 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDE2A	NP_002590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..42		9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..221		7/32 (22%)
		GAF	241..387	CDD:214500	27/162 (17%)
		GAF	409..558	CDD:214500	31/160 (19%)
		PDEase_I	655..888	CDD:459723	80/246 (33%)
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	28/158 (18%)
		PDEase_I	870..1110	CDD:459723	80/246 (33%)