|
Human 1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATI--KQCVVGPNHAAFLLE 63
|.|:.||:.||||::||..:|:||||:|:|::...|| .:.||..| |:.|:||.|...|||
Fly 1 MVSMQFVLQPLPGSDDQFIERIREVSDKVNRFGYGSH---RIFEQLKIPVKEVVIGPAHIGVLLE 62
Human 64 DGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTL 128
||:..|:.||:..::|:|.|.| :|.:::.|:|..| .|.:| |.|..:.|.....|
Fly 63 DGKAFRVSFSINSEKLDLTKSD----AKCSTSGGSGTAS----ASKAP---SSSRPMARSRARLL 116
Human 129 GSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQA 193
.:...|...|.|.|| |.|.||. .|...|:|...:||:.:||||||||
Fly 117 RATGRSNSTGQGSGS------------RSTGVII------GGSTSSRPLVTVPATYVPEELISQA 163
Human 194 QVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHS 258
:||||||||::|||||||||||||||||||||||||:.:|.::.| ::|:| |||:||||.....
Fly 164 EVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEEAEDTEEGA-DNYVP-EDLISLLDNGFSG 226
Human 259 AHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDS----------------- 305
.:.||||| :|.:|||:| :..|.|.|.....|:.|.|........||
Fly 227 DNNSVIIDPSDGLFSEEI-FSNYSSIRNLLFDRIRSERSNANANAADSNQSTTRSTSSGTALTGN 290
Human 306 -------ELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLG 357
.:..:||:..|.|: |||:....:..|:.:.||:.|| :|:.||:.:.
Fly 291 SGLSAQISVNADREAFSRWRDRQYYGPRRWISKDDYTWEKDADSKKKEP------SPMLSPIWIS 349
Human 358 EDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNE 422
|:||.||:|...:|..|||||||.:|:|..|:||||:||::|||: ::..:::||:...|.:. |
Fly 350 EELQPWPEKSSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYK-SETENVYHPKTVSLNIV-E 412
Human 423 KIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQL 487
::.|:|||.||.:|.||.|:||||:||.|..:.:||||:...::|...:.|..::.|:|||..:.
Fly 413 RVELISANFIRCSVVTETNRVATWMDEQLGYIGAKLEHSCCAFNEFISDSITKIYVCSLYTVVKT 477
Human 488 E-NSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSI 551
| |::|||||:||.||:.:.:|.|.|.|||..... .:|.||.||.::..|:|.:|::.|:.
Fly 478 ESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVA----TDINVGAQVIMKKCPMYQSGSIGFTC 538
Human 552 SAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEK----------------------------- 587
|.|:||||.|:.|||...|.||.::.:..:...::|
Fly 539 SNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTG 603
Human 588 ASKTTEAKPESKQEPVKTEMGPPPSPA-STCSDASSIASSASMPYKR-RRSTP-----APKEEEK 645
:||..::...||:...:.:|.|||||| |||||..|:.| :|| :|:|. ||:|..|
Fly 604 SSKNGQSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTS-----HKRTKRATTKEDSNAPQEGRK 663
Human 646 VNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFP------------GTSSNTNCQNSS--- 695
:||.|.:::|||||| |..||||||||||.:|||:|| .|||.:|..::|
Fly 664 -DEELWEVKDVVFVED-KVGPVGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEE 726
Human 696 GPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCI---PEKTEILAVNVDSKGVH 757
|.:.| .|.|||||.:::|:.:|..:.:.||..|:.|||:.: ....:||.:.|||:|:|
Fly 727 GKEDD----WQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVDSRGIH 787
Human 758 AVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIF----TAGQESPIILRDGNGT 818
.:.|....:.|.:::|...|.||...|||...:|:|....|:.:. .:|..|.|:||||||.
Fly 788 VIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNGA 852
Human 819 IYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPA---NSTIKKKAAVIIMAVEKQTLMQHI 880
:||:||||:|.|:||.|.||||:.|:.| |.|:||| ...:|.|..:..:..:.|.||.||
Fly 853 LYPLAKDCLGSIKDPQWFDLPPVKSITM---STISLPAMLSGVNLKSKVCMTALLFDTQKLMPHI 914
Human 881 LRCDYEACRQYLMNLEQ------AVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETK 939
||||.:.....|..||: |:|:|: ||||.|||.||||.:|.|:|||::.
Fly 915 LRCDVKNSFAALGRLEREDQADTALVVEE-----------RCDGARNIFHACVIMCAPSSNKDSP 968
Human 940 EEEEAERSERNTF-----------AERLSAVEAIANAISVVSSNG-------PGNRAGSSSSRS- 985
.:..:...|:.:. ....:.|.:||...|..|||. ..:.|||:||.|
Fly 969 PDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTSR 1033
Human 986 ---LRLREMMRR---SLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILA 1044
..||:||.| |.:|...|......::.|| :::|.|.. .
Fly 1034 DNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDH-----------AYIPWPAE-----------T 1076
Human 1045 PAVGSLTTAATGTGQGPSTS-------TIPGPSTEPSVVESK-----------DRKANAHFILKL 1091
||..:|:.::: |..|.| .||..|....:...| .|:.:|..||:.
Fly 1077 PAASNLSASSS---QNVSDSIEDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQ 1138
Human 1092 LCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMG 1156
:|.|..|:|||..:||.|||:|.||||.:||.|||.|.|.:|.|. :..||::..:...
Fly 1139 MCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTI-------LMLSEQDPQLKEA 1196
Human 1157 MVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDC 1221
|:.|:|:..|.|||:|:|.|||||||||||:||||:||||:||||..||||||||||||||||||
Fly 1197 MIFPNGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDC 1261
Human 1222 KLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQ 1286
|||||:||||||||||||||.||||..:.|..||.:|::.|:|||..||:||.:||||:|||.||
Fly 1262 KLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQ 1326
Human 1287 TVEHCQYR-PPRIRE--------------DRNRKTASPE-DSDMPDHDLEPPRFAQLALERVLQD 1335
.||..||| ..|:|. ..||||::.| |:||||||||||:||:.||||:|.|
Fly 1327 IVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLID 1391
Human 1336 WNALKSMIMFGSQENKDPLSASSRIGHLLPEE-QVYLNQQSGTIRLDCFTHCLIVKCTADILLLD 1399
|||::||||.|::....|..|.|...:...|. .:::..|.|:..||.|||.||||||:| .||
Fly 1392 WNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSD--HLD 1454
Human 1400 TLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEM---ASSKKKNNFIPQPIGKCK 1461
|||.|||:||||.....|.:||..|..||:|||||||||.::|. ...:|.::...:.:..|.
Fly 1455 TLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQSCV 1519
Human 1462 RVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPP----R 1522
:|||.|...::||||.|:|:||.|||:|:.|||||||::|:::| ::.|::||||:||.| .
Fly 1520 KVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLD-VRNSDDLFSVDPLAPSNVES 1583
Human 1523 PS---------SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGV 1578
|| :|||::.:..|:..::.....|..|:|:.|..|
Fly 1584 PSEQILVHDAGNDQSANFNIQQNYDVVAMETIRDASESEEVINR--------------------- 1627
Human 1579 AGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVV 1643
|.:.|::.:|..|.....:|..| ||..:|...: .|||||||:.|.|||: .:|||.
Fly 1628 --EANSHNQDDELIENQRNEDGMQD--DESDNDFTFN---DAETESDSDDNQSNQE---VQRSVQ 1682
Human 1644 TAATAGSEAGASSVPAFFSEDDSQSNDSSDSD-SSSSQSDDIEQETFMLDEPLERTTNSSHANGA 1707
..||.||| :.:...|.||:|..:.:.:.| |...:|||...|....::.|||.:.:|:|. :
Fly 1683 AGATVGSE---NDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNAR-S 1743
Human 1708 AQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEAS 1772
..||::||||: |:..||.||...|..|: :::|||..|||| |:..|......::|..
Fly 1744 DLAPQTMQWAI------RSRDTARSSVRVPTGSN--MVFIDPMALRRS-TVPASTTVTTPSIEPH 1799
Human 1773 NASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIP 1837
..: |:||:||||:.|.|||||:|:.:: .|| |.:.|..::|:...:|:.:|.:||::|..
Fly 1800 TMA---TTASNLARAFGITIRQISELISIL-SYN--VLNDIETSLKIQNDEAIAVQAFVEKRLKA 1858
Human 1838 TWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRAT 1902
||:||.::||.|||||::|:.|.:..||.||.|||:.|..::..:.......:|:..: .
Fly 1859 TWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGV------N 1917
Human 1903 LLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTL 1967
::.: ::|.||..|.|||||||..||.|.|||||:.:|:|:|||..|.:|::: |.....
Fly 1918 IMGS-----NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDSGFY 1975
Human 1968 DTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDD------SLP--AETGQNHPFFR 2024
| .::.:...|:|.....|:.|..::.|.|.:.:.| |:| ::..:.|.||.
Fly 1976 D--------KQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFA 2032
Human 2025 RSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVT 2089
||:|...|||..|..||:||..|:||||:|||||||:::::||......:.:::.:|| .|
Fly 2033 RSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG-----AT 2092
Human 2090 VD---RNCLEVLPTKMSYAANLK-------------------NVMNMQ----------NRQKKEG 2122
.| .:..:..||::.::.:|| ||.|.. ..:||:|
Fly 2093 NDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQG 2157
Human 2123 EE---------------QPVLPEETESSKPGPSAHDLA--------------AQLKSSLLAEIGL 2158
.: :.|:..||:.|.|..|....| |.:..:..|...:
Fly 2158 SDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVI 2222
Human 2159 TESEGPPL----------------TSFRPQC------------------------SFMGMVISHD 2183
..:.|..| |:.:.:| |....:.|.:
Fly 2223 VLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWN 2287
Human 2184 MLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSL-EVDRD 2247
.||.||:|:|:|||||||:|||.|.||:|.||.||.|||.:|||.||||||.|.|||.| :::|:
Fly 2288 FLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERN 2352
Human 2248 RDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLP 2310
|:.||.||.::||..||. |....|:..:||||||||||||||||||||||:||:|.|::.|:|
Fly 2353 RESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIP 2417
Human 2311 NLECIQNANKGTHTS-----LMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSI 2370
|||.:| .||:.| ....||:|......|::....||.|..:...|..|: |:.|::
Fly 2418 NLESVQ---VGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARE---RKALNL 2476
Human 2371 DTRPFRPASEGNPSDDPEP------LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLL 2429
|.||:.|. |.||:..| |..|.|.:||||||::.::....|.||||||||:...|||
Fly 2477 DARPYTPP---NSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLL 2538
Human 2430 LLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDD 2494
.:::|:::||.:|:||:|:|. ....||...|.::.: .|.|||.:|..|
Fly 2539 SVISSDETLRQKVNEAIEIIT---------------FKQKSETSAQSSQPK--KSPSVVVVDPVD 2586
Human 2495 TDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLL 2559
|||.||||.||||||||||.|..:..|:|.||||||::|||||||||.|:.|.|||:|.:|
Fly 2587 ----DDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYIL 2647
Human 2560 GRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNI 2624
|||:.:||.|||||.:|||.||:|..:|:.:.:...:.|:|.|.|||.||||.|..||||.|.::
Fly 2648 GRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDV 2712
Human 2625 PVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2689
.||..|::||||:|.|:|::...|:.|.|::.|:.||||.||:.:|||||.|||:||.|::||..
Fly 2713 AVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVST 2777
Human 2690 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITI 2754
|||:|:|||||.|..:|||:||:|||||||||::.||||||||||.||:||||||||||:||:||
Fly 2778 LISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTI 2842
Human 2755 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799
||.||.|||||||||||||:||||||.||:.|:|:|||:||||||
Fly 2843 RPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887
| 
