DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TAOK3 and STE7

DIOPT Version :9

Sequence 1:	NP_001333416.1	Gene:	TAOK3 / 51347	HGNCID:	18133	Length:	907	Species:	Homo sapiens
Sequence 2:	NP_010122.1	Gene:	STE7 / 851396	SGDID:	S000002318	Length:	515	Species:	Saccharomyces cerevisiae

Alignment Length:	347	Identity:	108/347 - (31%)
Similarity:	171/347 - (49%)	Gaps:	60/347 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    25 IGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLK-HPNTIEYK 88
            :.|.:||.|:.|.|..|.:...|::|| ||.....:........:::|:..::.:| |.|.|.:.
Yeast   192 VQLGKIGAGNSGTVVKALHVPDSKIVA-KKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFY 255

Human    89 GCYLKEH---TAWLVMEY--CLGSASDLLEVHKKPLQ------------EVEIAAITHGALHGLA 136
            |.|..:|   ...::|||  | ||...:|.|:|:.:|            |:.|:.|.:|.|:||.
Yeast   256 GAYYNQHINNEIIILMEYSDC-GSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLD 319

Human   137 YLH-SHALIHRDIKAGNILLTEPGQVKLADFGSAS--MASPANSFVGTPYWMAPEVILAMDEGQ- 197
            :|: .:.:||||||..|:|:...||:||.|||.:.  :.|.|::||||..:|:||.|    :|.
Yeast   320 HLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERI----QGNV 380

Human   198 YDGKVDIWSLGITCIELAERKPPLFNMN-----AMSALYHIAQNDSPTL-----QSNEWTDSFRR 252
            |..|.|:||||:..|||...:.||...|     .:..|..|....||.|     .|.|.||
Yeast   381 YSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTD---- 441

Human   253 FVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQY--RKMKKILFQE 315
            ||:.|..|..:||.:..|||.||.:.:         .:..:||     |..::  ||:|..:.::
Yeast   442 FVNRCCIKNERERSSIHELLHHDLIMK---------YVSPSKD-----DKFRHWCRKIKSKIKED 492

Human   316 TR--NGPLNESQEDEEDSEHGT 335
            .|  ...|:.::.:::.||..|
Yeast   493 KRIKREALDRAKLEKKQSERST 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAOK3	NP_001333416.1	STKc_TAO3	2..314	CDD:270803	103/322 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..362		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..605
STE7	NP_010122.1	PKc_Byr1_like	185..482	CDD:270792	100/313 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910