Protein Alignment FZR1 and CDH1

DIOPT Version :10

• Sequence 1: XP_016882352.1
• Gene: FZR1 / 51343
• HGNCID: 24824
• Length: 528
• Species: Homo sapiens
• Sequence 2: NP_011512.1
• Gene: CDH1 / 852881
• SGDID: S000002971
• Length: 566
• Species: Saccharomyces cerevisiae
• Alignment Length: 562
• Identity: 214/562 - (38%)
• Similarity: 306/562 - (54%)
• Gaps: 104/562 - (18%)

Human    64 TPASSP----------------------VSSPSK-------HGDRFIPSRAGANWSVNFHRINEN 99
            ||:|||                      :||||:       :|||:||||...::: :...|:..
Yeast    12 TPSSSPLKGSESKRVSKRPISSSSSASLLSSPSRRSRPSTVYGDRYIPSRTDIDFN-SIVSISSM 75

Human   100 EKSPSQNRKAKDATSDNGKDGLA---YSALLKNELLG-----------AGIEKVQD--PQT---- 144
            ...|:.|..:.:...:..|:..|   |:.||||||.|           :.|:::::  |.|
Yeast    76 ASVPALNPSSTEDQVEYQKERQAHETYNTLLKNELFGEMLSKDTVGSESSIDRIKNTRPSTRGNV 140

Human   145 ----------EDRRLQPSTPEKKGLFTYS-----LSTKR---SSPDD----------GNDVSPY- 180
                      |..|:....||..||..:|     ::.:|   |..|:          |..:..|
Yeast   141 HAENTTRHGYELERVSTPPPEAAGLEEFSPHSTPVTPRRLFTSQQDEITRPSSNSVRGASLLTYQ 205

Human   181 -------------------SLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVD 226
                               |:|||...|::||.||.|..|:|:|:|::|||||.|.||||.:|:|
Yeast   206 QRKGRRLSAASLLQSQFFDSMSPVRPDSKQLLLSPGKQFRQIAKVPYRVLDAPSLADDFYYSLID 270

Human   227 WSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAA 291
            |||.:||:|.||..::|....|..|..|||...|   .||:.|...|:.:|||...|.|:|:|..
Yeast   271 WSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENE---YTSLSWIGAGSHLAVGQANGLVEIYDVM 332

Human   292 AGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTD 356
            ..|.:..|.||..||..|:||...|:|||||..||.||:|.|....| .::.|.||||||||:..
Yeast   333 KRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFE-TIESHTQEVCGLKWNVA 396

Human   357 HQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLT 421
            ...||||||||.:.|:..:|.||:..:.||.|||||:|||||:.|:||:|||||||.::.||..|
Yeast   397 DNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNT 461

Human   422 GQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPD 486
            ...:..||:|||:||:.|||:.||||::||||:..:.:|...|:..:|.|.|||:|||:|.:|.|
Yeast   462 SIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSND 526

Human   487 GEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR 528
            |..:|:||||||||:|.:|.|.:: ||:..|: :.:.|.:||
Yeast   527 GTTVVSGAGDETLRYWKLFDKPKA-KVQPNSL-IFDAFNQIR 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FZR1	XP_016882352.1	WD40	<232..504	CDD:441893	133/271 (49%)
		WD40 repeat	264..301	CDD:293791	13/36 (36%)
		WD40 repeat	307..343	CDD:293791	16/35 (46%)
		WD40 repeat	348..384	CDD:293791	18/35 (51%)
		WD40 repeat	391..429	CDD:293791	20/37 (54%)
		WD40 repeat	434..472	CDD:293791	16/37 (43%)
		WD40 repeat	478..504	CDD:293791	16/25 (64%)
CDH1	NP_011512.1	WD40	269..543	CDD:475233	136/277 (49%)
		WD40 repeat	269..300	CDD:293791	13/30 (43%)
		WD40 repeat	305..342	CDD:293791	13/36 (36%)
		WD40 repeat	348..383	CDD:293791	16/35 (46%)
		WD40 repeat	388..424	CDD:293791	18/35 (51%)
		WD40 repeat	431..467	CDD:293791	20/35 (57%)
		WD40 repeat	474..512	CDD:293791	16/37 (43%)
		WD40 repeat	518..544	CDD:293791	16/25 (64%)