Protein Alignment FZR1 and fzr

DIOPT Version :10

• Sequence 1: XP_016882352.1
• Gene: FZR1 / 51343
• HGNCID: 24824
• Length: 528
• Species: Homo sapiens
• Sequence 2: NP_524852.2
• Gene: fzr / 45922
• FlyBaseID: FBgn0262699
• Length: 478
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 342/495 - (69%)
• Similarity: 391/495 - (78%)
• Gaps: 23/495 - (4%)

Human    36 DYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINE-N 99
            :||:|:|:       :..|....:......:::|.|.     |||||.||..||..||..||: |
  Fly     5 EYEKRILK-------HYSPVARNLFNNFESSTTPTSL-----DRFIPCRAYNNWQTNFASINKSN 57

Human   100 EKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTP-EKKGLFTYS 163
            :.||..::|.:|. .:..:|.||||.||||||||:.|:.|: ...|:|.....|| .|:.||.|.
  Fly    58 DNSPQTSKKQRDC-GETARDSLAYSCLLKNELLGSAIDDVK-TAGEERNENAYTPAAKRSLFKYQ 120

Human   164 LSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWS 228
            ..||:    |.|...||||||||.|||||||||||.|||||:|||||||||||||||||||||||
  Fly   121 SPTKQ----DYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWS 181

Human   229 SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAG 293
            |.|||:||||:|||||||||||||||||||.:.::||||.|:||||.||||||.|:|.:||.||.
  Fly   182 SQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAAN 246

Human   294 KKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQ 358
            |:::.|.||:|||||||||::.||||||||.|:|||.|||.|||||||.||||||||||||.|:|
  Fly   247 KQINKLNGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQ 311

Human   359 LLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQ 423
            .||||||||:|.|||..|::|||.||||:|||||||||||.||||||||||||||||||||||||
  Fly   312 YLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQ 376

Human   424 PLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGE 488
            |:||:||||||||||||||::||||||||||||||||||||||||||||||||||||||:|||||
  Fly   377 PMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGE 441

Human   489 AIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR 528
            |||||||||||||||||||.||.|   |:.||||||..||
  Fly   442 AIVTGAGDETLRFWNVFSKARSQK---ENKSVLNLFANIR 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FZR1	XP_016882352.1	WD40	<232..504	CDD:441893	224/271 (83%)
		WD40 repeat	264..301	CDD:293791	23/36 (64%)
		WD40 repeat	307..343	CDD:293791	28/35 (80%)
		WD40 repeat	348..384	CDD:293791	25/35 (71%)
		WD40 repeat	391..429	CDD:293791	35/37 (95%)
		WD40 repeat	434..472	CDD:293791	35/37 (95%)
		WD40 repeat	478..504	CDD:293791	24/25 (96%)
fzr	NP_524852.2	WD40	<194..457	CDD:441893	217/262 (83%)
		WD40 repeat	217..254	CDD:293791	23/36 (64%)
		WD40 repeat	260..296	CDD:293791	28/35 (80%)
		WD40 repeat	301..337	CDD:293791	25/35 (71%)
		WD40 repeat	344..382	CDD:293791	35/37 (95%)
		WD40 repeat	387..425	CDD:293791	35/37 (95%)
		WD40 repeat	431..457	CDD:293791	24/25 (96%)