Protein Alignment FZR1 and fzr1a

DIOPT Version :10

• Sequence 1: XP_016882352.1
• Gene: FZR1 / 51343
• HGNCID: 24824
• Length: 528
• Species: Homo sapiens
• Sequence 2: NP_956547.1
• Gene: fzr1a / 393223
• ZFINID: ZDB-GENE-040426-712
• Length: 495
• Species: Danio rerio
• Alignment Length: 499
• Identity: 455/499 - (91%)
• Similarity: 472/499 - (94%)
• Gaps: 7/499 - (1%)

Human    33 MDQDYERRLLRQIVIQNENTMP-RVTEMRRTLTPA-SSPVSSPSKHGDRFIPSRAGANWSVNFHR 95
            |||||||||||||.:||:||.| :..::...|||. .||:||||||||||||||||||||:||||
Zfish     1 MDQDYERRLLRQINVQNDNTSPMKAKDVICHLTPTPESPLSSPSKHGDRFIPSRAGANWSINFHR 65

Human    96 INENEKSPSQNRKAKDATSDNGK-DGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGL 159
            |||||||||||:|.||||||:|| |||||||||||||||||||||.|||||||||||||||::.|
Zfish    66 INENEKSPSQNKKTKDATSDSGKADGLAYSALLKNELLGAGIEKVLDPQTEDRRLQPSTPERRSL 130

Human   160 FTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNL 224
            |:||||.|||:||| |.||||||||||:|||||||||||||||||||||||||||||||||||||
Zfish   131 FSYSLSAKRSTPDD-NSVSPYSLSPVSSKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNL 194

Human   225 VDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWD 289
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   195 VDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWD 259

Human   290 AAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWS 354
            |.|||||..|||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Zfish   260 ATAGKKLFALEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWS 324

Human   355 TDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNT 419
            ||||||||||||||||||||||:.|:|||||||||||||||||||||||||||||||||||||||
Zfish   325 TDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNT 389

Human   420 LTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMS 484
            ||.||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
Zfish   390 LTAQPLQCIDTGSQVCNLAWSKHTNELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMS 454

Human   485 PDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR 528
            ||||||||||||||||||||||||||||   |||||||||||||
Zfish   455 PDGEAIVTGAGDETLRFWNVFSKTRSTK---ESVSVLNLFTRIR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FZR1	XP_016882352.1	WD40	<232..504	CDD:441893	262/271 (97%)
		WD40 repeat	264..301	CDD:293791	33/36 (92%)
		WD40 repeat	307..343	CDD:293791	34/35 (97%)
		WD40 repeat	348..384	CDD:293791	32/35 (91%)
		WD40 repeat	391..429	CDD:293791	36/37 (97%)
		WD40 repeat	434..472	CDD:293791	36/37 (97%)
		WD40 repeat	478..504	CDD:293791	25/25 (100%)
fzr1a	NP_956547.1	WD40	<202..474	CDD:441893	262/271 (97%)
		WD40 repeat	234..271	CDD:293791	33/36 (92%)
		WD40 repeat	277..313	CDD:293791	34/35 (97%)
		WD40 repeat	318..354	CDD:293791	32/35 (91%)
		WD40 repeat	361..399	CDD:293791	36/37 (97%)
		WD40 repeat	404..442	CDD:293791	36/37 (97%)
		WD40 repeat	448..489	CDD:293791	40/43 (93%)