Protein Alignment FZR1 and mfr1

DIOPT Version :10

• Sequence 1: XP_016882352.1
• Gene: FZR1 / 51343
• HGNCID: 24824
• Length: 528
• Species: Homo sapiens
• Sequence 2: NP_595081.1
• Gene: mfr1 / 2540043
• PomBaseID: SPBC1198.12
• Length: 421
• Species: Schizosaccharomyces pombe
• Alignment Length: 446
• Identity: 215/446 - (48%)
• Similarity: 285/446 - (63%)
• Gaps: 29/446 - (6%)

Human    77 GDRFIPSRAGAN-WSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQ 140
            ||||||.|..:| ::.:|....|...|...|.:.|    .:|.....:..||..||.|:...:.:
pombe     2 GDRFIPIRNVSNEFNFSFQSFKECVLSHGSNLRRK----TSGTIQRQFMELLSMELFGSQASRSR 62

Human   141 D-PQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKIS 204
            . ...||:|    ..|||.|             |..|...|||||:|.:||.:||.|:||.|...
pombe    63 AFYYGEDKR----KIEKKML-------------DTPDRKSYSLSPISPQSQDMLRQPQKPKRAFP 110

Human   205 KIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGW 269
            |.|:|:||||.|::||||||:||...|||:|||.:.:|||||.:.:|.:|.|.... :.||||.|
pombe   111 KTPYKILDAPYLKNDFYLNLLDWGQSNVLAVGLASSIYLWSAASGKVVQLHDFGAT-NHVTSVLW 174

Human   270 SERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPP 334
            :.:|..:||||..|.:.|||..:.|.:..|:||:.||.|||||...|:||.:|.:||..|:|.|.
pombe   175 TGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAWNDNTLTSGGKDEVILHHDLRAPG 239

Human   335 LQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 399
            ..:| .::.|.||:|||:|......||||||||.|.||::.|..|:.::.||.||||||.|||||
pombe   240 CCAE-MMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVKAIGWSPHQ 303

Human   400 HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPS 464
            .|:|||||||.|||:...|||||:....:||||||||:||||.:||:|:|||:::||:.:|||||
pombe   304 RGILASGGGTIDRCLTIHNTLTGRLQNKLDTGSQVCNMAWSKTSNEIVTTHGFAKNQVSLWKYPS 368

Human   465 LTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSV 520
            |..:|.||.|:.|||||:|||||::|||||||||||||.:|:|    |.|.||..:
pombe   369 LKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKLFNK----KPKEESTLI 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FZR1	XP_016882352.1	WD40	<232..504	CDD:441893	150/271 (55%)
		WD40 repeat	264..301	CDD:293791	16/36 (44%)
		WD40 repeat	307..343	CDD:293791	15/35 (43%)
		WD40 repeat	348..384	CDD:293791	17/35 (49%)
		WD40 repeat	391..429	CDD:293791	24/37 (65%)
		WD40 repeat	434..472	CDD:293791	22/37 (59%)
		WD40 repeat	478..504	CDD:293791	22/25 (88%)
mfr1	NP_595081.1	WD40	<138..408	CDD:441893	150/271 (55%)
		WD40 repeat	169..206	CDD:293791	16/36 (44%)
		WD40 repeat	212..247	CDD:293791	15/35 (43%)
		WD40 repeat	252..288	CDD:293791	17/35 (49%)
		WD40 repeat	295..333	CDD:293791	24/37 (65%)
		WD40 repeat	338..376	CDD:293791	22/37 (59%)
		WD40 repeat	382..408	CDD:293791	22/25 (88%)