DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB7A and egr1

DIOPT Version :9

Sequence 1:	XP_005259627.3	Gene:	ZBTB7A / 51341	HGNCID:	18078	Length:	634	Species:	Homo sapiens
Sequence 2:	NP_001090830.1	Gene:	egr1 / 100038164	XenbaseID:	XB-GENE-853412	Length:	499	Species:	Xenopus tropicalis

Alignment Length:	435	Identity:	102/435 - (23%)
Similarity:	165/435 - (37%)	Gaps:	109/435 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   182 LAADAGAD---AGQLDLVDQ--IDQRNLLRAKEYLEFF-------QSN-----PMNSLPPAAAAA 229
            |||||.:|   :|:..:::.  .:|...|.:..|...|       .||     |:.||.......
Frog    71 LAADAFSDMSLSGEKAVIESSYANQSARLPSLTYTGRFSLEPAPNSSNTLWPEPLFSLVSGLVGM 135

Human   230 AASFPWSAFGASDDDLDATKEAVAAAVAAVAAGDCNGLDFYGPGPPAERPPTGDGDEGDSNPGLW 294
            |.:.|.||..:|.....::.........:|.:.|.:.:....|..|            :|:|.|:
Frog   136 ANASPSSAPSSSPSSSSSSSSQSPPLSCSVQSNDSSPIYSAAPTFP------------NSSPELF 188

Human   295 PERD----EDAPTGGL-FPPPVAPPAATQNGHYGRGGEEEAASLSEAAPEPGDSPGFLSGAAEGE 354
            |::.    ::|.|..: :|||..|                   :|:...:....|.:|....:|
Frog   189 PDQSPQPFQNASTASIPYPPPAYP-------------------VSKTTFQVPMIPDYLFPQQQG- 233

Human   355 DGDGPDVDGLAA---------STLLQQMMSSVGRAGAAAGDSDEESRADDKGVMDYYLKYFSGAH 410
                 ||..::|         |...|..::.:....|.|..:.::            ||..:..:
Frog   234 -----DVSLVSADQKPFQAMESRTQQPSLTPLSTIKAFATQTSQD------------LKTINSTY 281

Human   411 DGDV--------YPAWSQKVEKKIRAKAFQKCPI--CEKVIQGAGKLPRHIRTHTGEKPYECNIC 465
            ...:        ||....|.....|..|   ||:  |::....:.:|.||||.|||:||::|.||
Frog   282 QSQIIKPSRMRKYPNRPSKTPPHERPYA---CPVESCDRRFSRSDELTRHIRIHTGQKPFQCRIC 343

Human   466 KVRFTRQDKLKVHMRKHTGEKPYLCQQCGAAFAHNYDLKNHMRVHTGLRPYQCDSCCKTFVRSDH 530
            ...|:|.|.|..|:|.||||||:.|..||..||.:.:.|.|.::|...:..:.|......|.|.
Frog   344 MRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKATPVSVASP- 407

Human   531 LHRHLKKDGCNGVPSRRGRKPRVRGGAPDPSPGATATPGAPAQPS 575
                        |.|   ..|......|.|.|.:.::|.:.|.||
Frog   408 ------------VSS---YSPSASTSYPSPVPTSYSSPVSSAYPS 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB7A	XP_005259627.3	None
egr1	NP_001090830.1	DUF3446	106..180	CDD:288757	14/73 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..309		4/20 (20%)
		zf-C2H2	308..332	CDD:278523	9/26 (35%)
		C2H2 Zn finger	310..332	CDD:275368	8/21 (38%)
		zf-H2C2_2	324..349	CDD:290200	14/24 (58%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		zf-H2C2_2	352..377	CDD:290200	13/24 (54%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..423		10/59 (17%)
		DUF3432	401..486	CDD:288743	12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910