DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PHF21A and CG7379

DIOPT Version :9

Sequence 1:	XP_011518459.1	Gene:	PHF21A / 51317	HGNCID:	24156	Length:	688	Species:	Homo sapiens
Sequence 2:	NP_650656.1	Gene:	CG7379 / 42140	FlyBaseID:	FBgn0038546	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	247	Identity:	50/247 - (20%)
Similarity:	77/247 - (31%)	Gaps:	101/247 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   390 EIQSKRQERKRRTTANPVYSGAVFE-------------------PERKKSAVTYLNSTMHPGTRK 435
            |:|....:|.||...:.|.:|:..|                   .|||.|    |......|..:
  Fly   224 ELQRTGSKRSRRRNESVVNNGSSLEMGGNESNSANEASGSGGGSGERKSS----LGGASGAGQGR 284

Human   436 RGRPPKYNAVLGFGALTPTS-----------------------------PQSSHPDSPENEKTET 471
            :......:..|..|:...:|                             ..:|:.::...|:|
  Fly   285 KASLQSASGSLASGSAATSSGAAGGGGASGAGVVGGNNSGKKKKRKVRGSGASNANASTREET-- 347

Human   472 TFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRK--SGQLLMCDT--CS-RVYHLDCLDPPLKTIP 531
                         |.|.:.|.| ...:| ||.:  .|::::||.  |. ..:|..|:...||  |
  Fly   348 -------------PPPETIDPD-EPTYC-VCNQISFGEMILCDNDLCPIEWFHFSCVSLVLK--P 395

Human   532 KGMWICPRCQD----------QMLKKEEAIPWPGTLAIVHSYIAYKAAKEEE 573
            ||.|.||.|:.          |.||:.|               .|...|||:
  Fly   396 KGKWFCPNCRGERPNVMKPKAQFLKELE---------------RYNKEKEEK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHF21A	XP_011518459.1	ING	<382..544	CDD:331088	42/216 (19%)
PHF21A	XP_011518459.1	PHD_PHF21A	498..540	CDD:276998	17/46 (37%)
CG7379	NP_650656.1	ING	17..116	CDD:289749
CG7379	NP_650656.1	PHD_ING1_2	360..404	CDD:277059	17/46 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910