Protein Alignment TLR8 and rdo

DIOPT Version :10

• Sequence 1: NP_057694.2
• Gene: TLR8 / 51311
• HGNCID: 15632
• Length: 1059
• Species: Homo sapiens
• Sequence 2: NP_001286024.1
• Gene: rdo / 35077
• FlyBaseID: FBgn0243486
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 132/613 - (21%)
• Similarity: 217/613 - (35%)
• Gaps: 205/613 - (33%)

Human   408 LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKR 472
            |.|...|..:.:..:.:..|..:.|.....|.|:.||:|.|:.:
  Fly    78 LRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNI--------------------- 121

Human   473 RSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 537
              |:..|....|...                ||||.|.:..:..:.|.:|.|:..|||:.||..:
  Fly   122 --TENNFRGQDNLLE----------------LDLSKNKVLRMASSTFRHLTDLRRLNLADNSIVE 168

Human   538 VLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFT 602
            ::. ..|..:..:|||||:.|.|.........::.:|:||... |....:|....::|     ..
  Fly   169 LVQ-RNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCR-NCQLKKINPQMYNL-----LP 226

Human   603 NLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLN 667
            .|..|:|..|....|......:.|.|.:::..||:|.::.:       .:|:..|:|..||||.|
  Fly   227 LLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVD-------QLFRMQKSLNHLDLSYN 284

Human   668 RLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSL 732
            ||..:||::||.| .:||.|.::.|.|.......::....|..|::.||.|:.|.:....|...:
  Fly   285 RLAKVPNDSFLQL-TNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRETFEPLI 348

Human   733 RTLLLSHNR--------ISHL--------PSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTK 781
            ....|:.::        ::||        |.|.|.....|::|::|.|   ::|.:|||.....:
  Fly   349 YYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLRYLNISGN---SLNNTALEVIDPCR 410

Human   782 ------LSMLELHG-------------------NPFEC-TCDIGDFRRWMDEHLNVKIPRLVDV- 819
                  ||..:|||                   ||..| .|.:|               :|::|
  Fly   411 ELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMG---------------KLINVV 460

Human   820 -----------ICASPGDQRGKSIVSLE---LTTCVSDV---------------------TAVIL 849
                       ||..|...||..|.:|:   |.||::.:                     |..||
  Fly   461 RQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAIL 525

Human   850 FFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDW 914
            ....|.:..:::|:.:|              |.:|
  Fly   526 GGIIFVLIAVIILSLVA--------------CFSK------------------------------ 546

Human   915 VINELRY-----HLEESRDKNVLLCLEE 937
              |..||     ||..|..|    |||:
  Fly   547 --NRARYYTREDHLNGSESK----CLEK 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLR8	NP_057694.2	LRR	81..460	CDD:443914	11/51 (22%)
		leucine-rich repeat	83..106	CDD:275380
		leucine-rich repeat	107..144	CDD:275380
		leucine-rich repeat	145..165	CDD:275380
		leucine-rich repeat	166..189	CDD:275380
		leucine-rich repeat	190..220	CDD:275380
		leucine-rich repeat	221..241	CDD:275380
		leucine-rich repeat	242..265	CDD:275380
		leucine-rich repeat	266..306	CDD:275380
		leucine-rich repeat	307..330	CDD:275380
		leucine-rich repeat	331..356	CDD:275380
		leucine-rich repeat	387..413	CDD:275380	2/4 (50%)
		leucine-rich repeat	414..437	CDD:275380	3/22 (14%)
		LRR	483..>793	CDD:443914	86/350 (25%)
		leucine-rich repeat	504..524	CDD:275380	7/19 (37%)
		leucine-rich repeat	525..549	CDD:275380	6/23 (26%)
		leucine-rich repeat	550..573	CDD:275380	7/22 (32%)
		leucine-rich repeat	574..603	CDD:275380	6/28 (21%)
		leucine-rich repeat	604..658	CDD:275380	11/53 (21%)
		leucine-rich repeat	659..683	CDD:275380	13/23 (57%)
		leucine-rich repeat	684..707	CDD:275380	5/22 (23%)
		leucine-rich repeat	708..730	CDD:275380	7/21 (33%)
		leucine-rich repeat	732..755	CDD:275380	6/38 (16%)
		leucine-rich repeat	756..775	CDD:275380	6/18 (33%)
		PCC	760..>847	CDD:188093	29/148 (20%)
		TIR	898..1040	CDD:214587	10/45 (22%)
rdo	NP_001286024.1	LRR	69..>446	CDD:443914	98/424 (23%)
		leucine-rich repeat	84..107	CDD:275380	3/22 (14%)
		leucine-rich repeat	108..131	CDD:275380	8/45 (18%)
		leucine-rich repeat	132..155	CDD:275380	7/38 (18%)
		leucine-rich repeat	156..179	CDD:275380	6/23 (26%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..251	CDD:275380	11/52 (21%)
		leucine-rich repeat	252..275	CDD:275380	5/29 (17%)
		leucine-rich repeat	276..299	CDD:275380	13/23 (57%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	388..411	CDD:275380	8/25 (32%)