DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR8 and CG4168

DIOPT Version :10

Sequence 1:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens
Sequence 2:NP_609740.4 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster


Alignment Length:1149 Identity:281/1149 - (24%)
Similarity:433/1149 - (37%) Gaps:359/1149 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    66 ECSNRRLQEVPQTVGKY----VTELDLSDNFITHITNESFQGLQNLTKINLNHN----------- 115
            :.||.|:..|   .|.|    :..:|||.|.:|....:.|:.|..|..::|..|           
  Fly   270 DLSNNRIYHV---AGNYLPRSLVTMDLSSNLLTVFPQQLFEQLPELRIVSLRDNLIRSVQWKELQ 331

Human   116 --PNVQH-------QNGNPGIQSNGL--NITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTEL 169
              |...|       ||....::|:..  |.:|      .:||.|.||.|.:.|:|          
  Fly   332 VRPLRMHLERLDLGQNCIENLESDYFQQNYSD------VHLRALNLEQNFVTQLP---------- 380

Human   170 SLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLT-NLELLSLSFNSLSH 233
                        |.:.:...:.:|.||:|..       :.:....||.|| .||.|.|..|.|:.
  Fly   381 ------------EAVFKATGIAHLVLAFNAI-------SRVHPSAFEGLTETLEYLDLERNRLTT 426

Human   234 VPPKLPS--SLRKLFLSNTQIKYISE-EDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN 295
            ||..|.|  .|:.|:|::.||..::. ..|..  ||.:|.||||       .|..:|..|     
  Fly   427 VPVALSSLHHLKYLYLTSNQISQLNNLPSFTE--NLRVLSLSGN-------NFSMIPVLG----- 477

Human   296 IDRFAFQNLTQLRYLNLSSTSLRKINA------AWFKNMPHLKVLDLEFNYL-VGEIASGAFLTM 353
                 .:|.|||.|||:...|:..|..      :|..|:..:.:.:.:..:| :|..|.      
  Fly   478 -----LKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKITHLHLGSFAG------ 531

Human   354 LPRLEILDLSFNYIKGSYPQHI-NISRNFSKLLSLRALHLRGYVFQELREDDFQP---LMQLPNL 414
            |.:::.:.||||.|...:|... |:||      :|:.|.|...||.....:...|   |:.|..|
  Fly   532 LEQIQEISLSFNDITIHHPLVFENVSR------TLKILELSFAVFPARSLESLDPLDALLPLSQL 590

Human   415 STINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEF 479
            ..:.|..|.:||:..:.|.....|..|.||.|::..|.:..                     |:.
  Fly   591 IWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRGL---------------------FQS 634

Human   480 DPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEF 544
            |.||:...                :|||.|.:..:....|.:|.|:..|||.:| ..:.::...|
  Fly   635 DAHSHLVE----------------IDLSYNGLERLEAQTFHSLGDLQTLNLQSN-RLRTIARHAF 682

Human   545 SAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN------------------------SH- 584
            ..:..::||||:.|||...:..|.|.|.:|..|||.:|                        || 
  Fly   683 HNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHN 747

Human   585 -------------YFRIAGVTH-HLEFIQNFTN----LKVLNLSHNNIYTLTDKYNLESKSLVEL 631
                         |.....::| |:....:|||    |:.|||:||.:      .:|:|.:..:|
  Fly   748 HIASFYDELSSYMYIYQLDISHNHVTKSDSFTNLANTLRFLNLAHNQL------GSLQSHAFGDL 806

Human   632 VFSGNRLDILWNDDDNRYISI----FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDN 692
            .|    |:|| |...|...|:    |:||.:|..||||.|:|..:..|.|.|| ..|..|.||.|
  Fly   807 EF----LEIL-NVAHNNLTSLRRRSFQGLNSLQELDLSHNQLDQLQVEQFSNL-RKLRILRINSN 865

Human   693 MLK------FFNWTLLQQFPRLELLDLRGNKL-LFLTDSLSDFTSSLRTLLLSH----------- 739
            .|:      |.|       .|||.||:..|:| ::...:.:|...:||::.:||           
  Fly   866 RLRALPREVFMN-------TRLEFLDIAENQLSVWPVPAFTDIGFTLRSIQMSHNNLEYLDASMF 923

Human   740 -------------NRISHLPSGFLSEVSSLKHLDLSSNLLKTIN--KSALETKTTTKLSM----- 784
                         |||:.||....|.:::|.:||||.|.|.|.|  :..:.|....|||:     
  Fly   924 INSQFLYDISLARNRITILPDNTFSFLNNLTNLDLSQNPLVTTNLREVFVHTPRLRKLSLHHMGL 988

Human   785 -------------LELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE 836
                         |::.||..:....:|..|..  .|:||...:|.:..||:  :....|:..|:
  Fly   989 YVLPPLKLPLLSYLDVSGNYLQELSPLGSLRHL--RHVNVSHNKLTNASCAA--EHLPPSVRVLD 1049

Human   837 LTTCVSDVTAVILFFFTFFITTMVMLAALAH--HLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYD 899
            |..  :.:..:          |:..||:|.|  .|...||........:|::..|.|..|     
  Fly  1050 LAH--NPLRRI----------TLHDLASLRHLAELNILDVKVTNPQAFSKLRSLRKLHAS----- 1097

Human   900 AYISYDTKDASVTDWV-----INELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKK 959
                   ..|::.:.|     :.:||.|           |||           .|:.|.:     
  Fly  1098 -------SHANLGEIVARIPGLQQLRVH-----------CLE-----------PNIGQQL----- 1128

Human   960 TVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVI---IFILLEPVLQHSQYLRLRQRICKSSILQ 1021
                    :||..|...   :.|..|...|:..|   :|..|      |:..||:.:|..:.|..
  Fly  1129 --------FAKLANNTK---IRLLELYGSNVQTIAPDVFTGL------SRSQRLQVKISHTRISD 1176

Human  1022 WPDNPKAEGLFWQTLRNVVLTEND---SRYNNMYVDSI---KQY 1059
            .|     .|:|: .||.|.....|   :|.|.:..||.   |.|
  Fly  1177 LP-----PGIFY-ALREVPHLSIDISHNRINALAADSFYPNKSY 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR8NP_057694.2 LRR 81..460 CDD:443914 105/419 (25%)
leucine-rich repeat 83..106 CDD:275380 7/22 (32%)
leucine-rich repeat 107..144 CDD:275380 10/58 (17%)
leucine-rich repeat 145..165 CDD:275380 8/19 (42%)
leucine-rich repeat 166..189 CDD:275380 1/22 (5%)
leucine-rich repeat 190..220 CDD:275380 8/30 (27%)
leucine-rich repeat 221..241 CDD:275380 10/21 (48%)
leucine-rich repeat 242..265 CDD:275380 6/23 (26%)
leucine-rich repeat 266..306 CDD:275380 10/39 (26%)
leucine-rich repeat 307..330 CDD:275380 8/28 (29%)
leucine-rich repeat 331..356 CDD:275380 4/25 (16%)
leucine-rich repeat 387..413 CDD:275380 8/28 (29%)
leucine-rich repeat 414..437 CDD:275380 6/22 (27%)
LRR 483..>793 CDD:443914 108/407 (27%)
leucine-rich repeat 504..524 CDD:275380 6/19 (32%)
leucine-rich repeat 525..549 CDD:275380 5/23 (22%)
leucine-rich repeat 550..573 CDD:275380 10/22 (45%)
leucine-rich repeat 574..603 CDD:275380 11/67 (16%)
leucine-rich repeat 604..658 CDD:275380 19/57 (33%)
leucine-rich repeat 659..683 CDD:275380 11/23 (48%)
leucine-rich repeat 684..707 CDD:275380 8/28 (29%)
leucine-rich repeat 708..730 CDD:275380 7/22 (32%)
leucine-rich repeat 732..755 CDD:275380 10/46 (22%)
leucine-rich repeat 756..775 CDD:275380 9/20 (45%)
PCC 760..>847 CDD:188093 25/106 (24%)
TIR 898..1040 CDD:214587 29/149 (19%)
CG4168NP_609740.4 PRK15370 <69..>353 CDD:185268 20/85 (24%)
leucine-rich repeat 99..118 CDD:275380
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
leucine-rich repeat 266..287 CDD:275380 6/19 (32%)
leucine-rich repeat 288..311 CDD:275380 7/22 (32%)
leucine-rich repeat 312..338 CDD:275380 4/25 (16%)
LRR <338..651 CDD:443914 101/415 (24%)
leucine-rich repeat 339..365 CDD:275380 5/31 (16%)
leucine-rich repeat 366..388 CDD:275380 9/43 (21%)
leucine-rich repeat 389..412 CDD:275380 7/29 (24%)
leucine-rich repeat 414..436 CDD:275380 10/21 (48%)
leucine-rich repeat 437..459 CDD:275380 6/23 (26%)
leucine-rich repeat 460..483 CDD:275380 10/39 (26%)
leucine-rich repeat 484..510 CDD:275380 7/25 (28%)
leucine-rich repeat 511..534 CDD:275380 4/28 (14%)
leucine-rich repeat 535..589 CDD:275380 17/59 (29%)
LRR 543..971 CDD:443914 130/490 (27%)
leucine-rich repeat 590..613 CDD:275380 6/22 (27%)
leucine-rich repeat 614..639 CDD:275380 9/45 (20%)
leucine-rich repeat 640..663 CDD:275380 6/38 (16%)
leucine-rich repeat 664..687 CDD:275380 5/23 (22%)
leucine-rich repeat 688..711 CDD:275380 10/22 (45%)
leucine-rich repeat 712..735 CDD:275380 5/22 (23%)
leucine-rich repeat 740..783 CDD:275380 8/42 (19%)
leucine-rich repeat 785..808 CDD:275380 9/28 (32%)
leucine-rich repeat 809..832 CDD:275380 9/23 (39%)
leucine-rich repeat 833..856 CDD:275380 11/23 (48%)
leucine-rich repeat 857..879 CDD:275380 8/28 (29%)
leucine-rich repeat 880..900 CDD:275380 6/19 (32%)
leucine-rich repeat 905..928 CDD:275380 4/22 (18%)
LRR 911..>1203 CDD:443914 80/369 (22%)
leucine-rich repeat 929..952 CDD:275380 6/22 (27%)
leucine-rich repeat 953..977 CDD:275380 10/23 (43%)
leucine-rich repeat 978..1020 CDD:275380 7/41 (17%)
leucine-rich repeat 1045..1068 CDD:275380 6/34 (18%)
leucine-rich repeat 1069..1090 CDD:275380 4/20 (20%)
leucine-rich repeat 1091..1114 CDD:275380 5/34 (15%)
leucine-rich repeat 1115..1161 CDD:275380 17/89 (19%)
leucine-rich repeat 1162..1190 CDD:275380 10/33 (30%)
PCC 1230..>1298 CDD:188093
Blue background indicates that the domain is not in the aligned region.

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