DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR8 and Toll-4

DIOPT Version :10

Sequence 1:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:1262 Identity:258/1262 - (20%)
Similarity:454/1262 - (35%) Gaps:442/1262 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    45 EENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNL-T 108
            |..|  .:..|.::|....:..|:|:  .:.|.                :|..::|....:|| :
  Fly    15 ERRF--KWTSDGQQQQQQQLGWCNNK--DDPPN----------------SHQKSKSNNDARNLNS 59

Human   109 KINLNHNPNVQHQNGNPG-IQSNGLNITDGAFLNLKNLR----ELLLEDNQLPQIPSGLPESLTE 168
            ::.:.....|.     || ::...:|.::|    |.|:|    |:.|::         |.|:.| 
  Fly    60 RVRVRARVRVV-----PGEMRMGDINCSNG----LGNIREDYCEIYLDE---------LGENGT- 105

Human   169 LSLIQNNIYNITKEGISRLINLK-------NLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSL 226
            .|:..|.:  .|::...:|:.||       .::..||.:  |:|.:|:.|      |..:.:|.:
  Fly   106 CSIANNEV--TTEDYQMKLVFLKLEINWTSPVFHGWNIF--KICNETDYE------LVIISVLGI 160

Human   227 SFNSLSHVPPKLPSSLRKLFLSNTQIKYISEED-FKGLINLTLLDL-SGNCPRCFNAPFPCVPCD 289
            .    |.|..::..:::  :||...|:.||..| :...:.:|.:|: ..|.|:.....:..    
  Fly   161 R----SEVDMRISPAVQ--YLSLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLY---- 215

Human   290 GGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTML 354
             .:::|       ::....|:..:..:..||. .::.|......|.:|.|...|:....|     
  Fly   216 -DSTVN-------SVITNNYIRKTMNNTEKIK-IYYHNTFEKTTLTMEKNIFHGKNKMSA----- 266

Human   355 PRLEILDLSFN--YIKGSYPQHINISRN-FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLST 416
                   |.||  .|||       ::.| |..|.||..|     :|..:...|...|..    ||
  Fly   267 -------LIFNGLKIKG-------LTNNTFENLTSLNTL-----IFDNVFLKDLSFLRS----ST 308

Human   417 INLGINFI-----KQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTD 476
            :...:.:.     ..:|.|.|:.|:|||||.:|:             |....:|         |.
  Fly   309 LQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQ-------------YKGFKNF---------TA 351

Human   477 FEFDPHSNFYHFTRPLIKPQC-----AAYGK----------------------------ALDLSL 508
            |..:|:.:...||..:.:..|     .:|.:                            ||....
  Fly   352 FICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQS 416

Human   509 NSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPH-VKYLDLTNNRLDFDNASALTELS 572
            |.:..:..|..|...::..|::|.|.    |:....|.:|. :.|||:.:|:        :|.||
  Fly   417 NLLAELPDNSLEGYHNLKSLDVSYNQ----LTSLSVSQLPESLHYLDIRHNK--------ITTLS 469

Human   573 DLEVLDLSYNSHYFRIAG-------VTHHLE-------------------------------FIQ 599
            . :|::..|:.:.|...|       ..:||:                               |::
  Fly   470 P-QVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVE 533

Human   600 NF--TNLKVLNLSHN-----NIYTLTDKY-NLESKSLVEL------VFSGNRLDIL--------- 641
            ||  .|:..|.|..|     :.:..:||| ||:   |:|.      :|||...:|:         
  Fly   534 NFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLK---LMEALNHAIWLFSGEFDEIILHHLNSPCP 595

Human   642 --------WNDDD------NRYISIFKGLKN----LTRLDLSLNRLKHIPNEAFLNLP--ASLTE 686
                    |:..:      |..:.|:..|.|    .|.|.|..|.::.:.|...|.:.  ||:.:
  Fly   596 YRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHK 660

Human   687 LHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL-------------------------- 725
            ||::.|:|:.....||.:  .:..||:|.|.|.:|.|.:                          
  Fly   661 LHMSQNLLRELPLHLLPE--NITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKA 723

Human   726 SDFTSSLR--------------------------------------------------------- 733
            ..|.|.||                                                         
  Fly   724 KAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTP 788

Human   734 -----TLLLSHNRISHLPSGFLSEVSS--------------------LKHLDLSSN--------- 764
                 ||:...|.:...||..|...||                    |::||:|:|         
  Fly   789 TYGQTTLVFERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRV 853

Human   765 ---LLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEH----LNVKIPRLVDVICA 822
               |.|.:|.|.|:         |.|.|||:.|.|:..||..::.|.    .|....:.:|.   
  Fly   854 RGFLQKRMNSSQLQ---------LSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDT--- 906

Human   823 SPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYW-----DVWFI-YNVC 881
                  |:|::.:|.|    |:...:|.::|....::::: ||:.::|..     .:||. :.:|
  Fly   907 ------GRSLIEVEET----DICPSVLIYYTSLAVSLLII-ALSINVFICFRQPIMIWFYEHEIC 960

Human   882 LAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAI 946
            |: :...|.|...:. |||::|:..||..    :|.|....||..|.| ..||...|||..|.:|
  Fly   961 LS-LAARRELDEDKK-YDAFLSFTHKDED----LIEEFVDRLENGRHK-FRLCFYLRDWLVGESI 1018

Human   947 IDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYL--R 1009
            .|.:.||:..|::.:.::||.:.||...:..|.|||.....:....:| ::|.|.::|...|  .
  Fly  1019 PDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLI-VVLYPDVEHFDDLDSE 1082

Human  1010 LRQRICKSSILQWPDNPKAEGLFWQTL 1036
            ||..:..::.|. .:||.    ||..|
  Fly  1083 LRAYMVLNTYLD-RNNPN----FWNKL 1104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR8NP_057694.2 LRR 81..460 CDD:443914 80/401 (20%)
leucine-rich repeat 83..106 CDD:275380 2/22 (9%)
leucine-rich repeat 107..144 CDD:275380 7/38 (18%)
leucine-rich repeat 145..165 CDD:275380 4/23 (17%)
leucine-rich repeat 166..189 CDD:275380 5/22 (23%)
leucine-rich repeat 190..220 CDD:275380 9/36 (25%)
leucine-rich repeat 221..241 CDD:275380 3/19 (16%)
leucine-rich repeat 242..265 CDD:275380 6/23 (26%)
leucine-rich repeat 266..306 CDD:275380 5/40 (13%)
leucine-rich repeat 307..330 CDD:275380 4/22 (18%)
leucine-rich repeat 331..356 CDD:275380 5/24 (21%)
leucine-rich repeat 387..413 CDD:275380 5/25 (20%)
leucine-rich repeat 414..437 CDD:275380 6/27 (22%)
LRR 483..>793 CDD:443914 99/544 (18%)
leucine-rich repeat 504..524 CDD:275380 4/19 (21%)
leucine-rich repeat 525..549 CDD:275380 5/23 (22%)
leucine-rich repeat 550..573 CDD:275380 6/22 (27%)
leucine-rich repeat 574..603 CDD:275380 9/68 (13%)
leucine-rich repeat 604..658 CDD:275380 18/88 (20%)
leucine-rich repeat 659..683 CDD:275380 6/25 (24%)
leucine-rich repeat 684..707 CDD:275380 6/22 (27%)
leucine-rich repeat 708..730 CDD:275380 8/47 (17%)
leucine-rich repeat 732..755 CDD:275380 8/84 (10%)
leucine-rich repeat 756..775 CDD:275380 9/30 (30%)
PCC 760..>847 CDD:188093 25/102 (25%)
TIR 898..1040 CDD:214587 44/141 (31%)
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 63/334 (19%)
leucine-rich repeat 264..287 CDD:275380 10/41 (24%)
leucine-rich repeat 288..308 CDD:275380 5/28 (18%)
leucine-rich repeat 309..334 CDD:275380 4/24 (17%)
leucine-rich repeat 335..386 CDD:275380 14/72 (19%)
PRK15370 <381..>482 CDD:185268 20/113 (18%)
leucine-rich repeat 388..408 CDD:275380 0/19 (0%)
leucine-rich repeat 412..432 CDD:275378 4/19 (21%)
LRR <416..591 CDD:443914 40/190 (21%)
leucine-rich repeat 433..454 CDD:275378 6/24 (25%)
leucine-rich repeat 455..478 CDD:275378 8/31 (26%)
leucine-rich repeat 479..490 CDD:275378 2/10 (20%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 6/22 (27%)
leucine-rich repeat 680..706 CDD:275378 7/25 (28%)
PCC 684..>771 CDD:188093 10/86 (12%)
leucine-rich repeat 707..719 CDD:275378 0/11 (0%)
leucine-rich repeat 771..791 CDD:275380 0/19 (0%)
PRK15370 <793..>877 CDD:185268 23/92 (25%)
leucine-rich repeat 793..815 CDD:275378 6/21 (29%)
leucine-rich repeat 816..835 CDD:275378 0/18 (0%)
leucine-rich repeat 836..859 CDD:275378 6/22 (27%)
TIR 974..1110 CDD:214587 44/143 (31%)

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