Protein Alignment TLR8 and kek5

DIOPT Version :10

• Sequence 1: NP_057694.2
• Gene: TLR8 / 51311
• HGNCID: 15632
• Length: 1059
• Species: Homo sapiens
• Sequence 2: NP_573382.1
• Gene: kek5 / 32930
• FlyBaseID: FBgn0031016
• Length: 931
• Species: Drosophila melanogaster
• Alignment Length: 290
• Identity: 68/290 - (23%)
• Similarity: 117/290 - (40%)
• Gaps: 91/290 - (31%)

Human   567 ALTEL-----SDLEVLDLSYNS------HYFRIAGVTH-HLEFIQNFTNLKVLNLSHNNIYTLTD 619
            |||::     ::::|||.::|.      ..|.:||:.: |..|::|.|..:|...:...::.
  Fly    63 ALTKIPQDMSNEMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHI--- 124

Human   620 KYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASL 684
                    |:||..||||:..|       :...|.||:.|..:.::.|.::.:||..|:|| :.|
  Fly   125 --------LIELDLSGNRIREL-------HPGTFAGLEKLRNVIINNNEIEVLPNHLFVNL-SFL 173

Human   685 TELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGF 749
            :.:...:|.|:           :::|....|             |.:|..:.|..||:|||....
  Fly   174 SRIEFRNNRLR-----------QVQLHVFAG-------------TMALSAISLEQNRLSHLHKET 214

Human   750 LSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKI- 813
            ..::..|.|                          |.|.||.:.|:|::.|||   |..::.::
  Fly   215 FKDLQKLMH--------------------------LSLQGNAWNCSCELQDFR---DFAISKRLY 250

Human   814 -PRLVDVICASPGDQRGK--SIVSLELTTC 840
             |   ...|..|...|||  |.|..|...|
  Fly   251 TP---PTDCQEPPQLRGKLWSEVPSENFAC 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLR8	NP_057694.2	LRR	81..460	CDD:443914
		leucine-rich repeat	83..106	CDD:275380
		leucine-rich repeat	107..144	CDD:275380
		leucine-rich repeat	145..165	CDD:275380
		leucine-rich repeat	166..189	CDD:275380
		leucine-rich repeat	190..220	CDD:275380
		leucine-rich repeat	221..241	CDD:275380
		leucine-rich repeat	242..265	CDD:275380
		leucine-rich repeat	266..306	CDD:275380
		leucine-rich repeat	307..330	CDD:275380
		leucine-rich repeat	331..356	CDD:275380
		leucine-rich repeat	387..413	CDD:275380
		leucine-rich repeat	414..437	CDD:275380
		LRR	483..>793	CDD:443914	52/237 (22%)
		leucine-rich repeat	504..524	CDD:275380
		leucine-rich repeat	525..549	CDD:275380
		leucine-rich repeat	550..573	CDD:275380	3/10 (30%)
		leucine-rich repeat	574..603	CDD:275380	10/35 (29%)
		leucine-rich repeat	604..658	CDD:275380	12/53 (23%)
		leucine-rich repeat	659..683	CDD:275380	7/23 (30%)
		leucine-rich repeat	684..707	CDD:275380	3/22 (14%)
		leucine-rich repeat	708..730	CDD:275380	2/21 (10%)
		leucine-rich repeat	732..755	CDD:275380	7/22 (32%)
		leucine-rich repeat	756..775	CDD:275380	2/18 (11%)
		PCC	760..>847	CDD:188093	20/85 (24%)
		TIR	898..1040	CDD:214587
kek5	NP_573382.1	LRR	<76..>229	CDD:443914	47/221 (21%)
		leucine-rich repeat	76..100	CDD:275380	7/23 (30%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		leucine-rich repeat	125..148	CDD:275380	11/29 (38%)
		leucine-rich repeat	149..172	CDD:275380	7/23 (30%)
		leucine-rich repeat	173..196	CDD:275380	6/46 (13%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		LRRCT	229..277	CDD:214507	16/53 (30%)
		Ig	296..379	CDD:472250
		Ig strand B	296..300	CDD:409353
		Ig strand C	309..313	CDD:409353
		Ig strand E	345..349	CDD:409353
		Ig strand F	359..364	CDD:409353
		Ig strand G	372..375	CDD:409353