Protein Alignment KCNK9 and Task6

DIOPT Version :10

• Sequence 1: NP_001269463.1
• Gene: KCNK9 / 51305
• HGNCID: 6283
• Length: 374
• Species: Homo sapiens
• Sequence 2: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 385
• Identity: 175/385 - (45%)
• Similarity: 234/385 - (60%)
• Gaps: 40/385 - (10%)

Human     1 MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELV 65
            ||:|||||:||||||||||||||||||||||:.|.|..|.|:..|..|..|||||.||::.:|.|
  Fly     1 MKKQNVRTISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYNISQEDFKVMETV 65

Human    66 ILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGE 130
            :|:||.|:||.||||.|:||:|.||:|||||||:.|.|..||.|.|.||::||||.||||||:||
  Fly    66 VLKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMFQSIGE 130

Human   131 RMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFI 195
            |:|....|::|.::.....:.|..|..:::.|.......|:..||||||:.|.||:|.:.|||||
  Fly   131 RVNRLSSYVIKAVRSSLRCKRTVASEVDLICVVTTLSSLTIAGGAAAFSKFEGWSYFDSVYYCFI 195

Human   196 TLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEE 260
            |||||||||.||||...||.:||.||.|:.::||.||.::.|.|||:||||:|||:||||||..:
  Fly   196 TLTTIGFGDMVALQRDNALNRKPEYVMFALIFILFGLAIVAASLNLLVLRFVTMNTEDERRDEAQ 260

Human   261 -------RASLAGN---RNSMVI-----HIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGR 310
                   ...|.|:   .|..::     |..:....|         :..|:|||.|....  |.|
  Fly   261 AMQALQVAVKLEGDVITSNGSILSGYEGHDGQSLNGS---------NTSSMCSCHCICLN--GNR 314

Human   311 SVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPS--PISSI-----SPGLHSFTD 363
                 :..|:.|..:......||:.: ||:.::: |.|.  |:..:     :..||:..|
  Fly   315 -----HKKSSNLEKNNDAENQYKLRQ-SPTHIRH-LLPEVVPMQDLNYDYDTQSLHTLAD 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK9	NP_001269463.1	Ion_trans_2	<73..132	CDD:462301	39/58 (67%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98		4/4 (100%)
		Ion_trans_2	<183..243	CDD:462301	36/59 (61%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204		4/4 (100%)
		X-gate. /evidence=ECO:0000269|PubMed:38630723	243..248		4/4 (100%)
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	36/53 (68%)
		Ion_trans_2	165..243	CDD:462301	44/77 (57%)