Protein Alignment KCNK9 and Shal

DIOPT Version :10

• Sequence 1: NP_001269463.1
• Gene: KCNK9 / 51305
• HGNCID: 6283
• Length: 374
• Species: Homo sapiens
• Sequence 2: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Alignment Length: 436
• Identity: 77/436 - (17%)
• Similarity: 130/436 - (29%)
• Gaps: 172/436 - (39%)

Human    32 DHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPH--RAGVQWKFAGSFYFAIT----V 90
            |.:....|:|..:::...|..|:......:.::......||  .:.:.:.:...|:.|::    |
  Fly   139 DRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANV 203

Human    91 ITTIGYGHAAPGTDAGKA----------FCM---------------------------------- 111
            :.|:..|| .||. ||..          ||:
  Fly   204 VETVPCGH-RPGR-AGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIID 266

Human   112 ------FYAVLGIP---------LTLVMFQSLG----ERMNTFVRYLLKRIKKCCGMRNTDVSME 157
                  :|..|||.         :||.:|:...    .|.:..:|.|...:|.|..
  Fly   267 VVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS--------- 322

Human   158 NMVTVGF--FSCMGTLCIGAAAFSQCEE-------WSFFHAYYYCFITLTTIGFGDYVALQTKGA 213
               .:||  ||....:.|.|......|:       .|...|::|..:|:||:|:||.|.....|.
  Fly   323 ---ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGK 384

Human   214 LQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTM---NSEDERRDAEERASLA---------- 265
            :        ...:..|.|:.||...:.::|..|..:   |...::|.|:.:|.||
  Fly   385 I--------VGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSG 441

Human   266 -----------------------------------------------GNRNSMVIHIPEEPRPSR 283
                                                           .:|..:.:.||...:|.|
  Fly   442 AAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKR 506

Human   284 PRYKADVPD-----------LQSVCS-CTCYRSQDYGGRSVAPQNS 317
            |...:.:..           |||.|. |...|.|..|....|..|:
  Fly   507 PGSPSPMASPAHSTNSAAGLLQSCCGRCCSQRYQACGKYMPAASNA 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK9	NP_001269463.1	Ion_trans_2	<73..132	CDD:462301	19/125 (15%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98		1/4 (25%)
		Ion_trans_2	<183..243	CDD:462301	15/66 (23%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204		2/4 (50%)
		X-gate. /evidence=ECO:0000269|PubMed:38630723	243..248		2/4 (50%)
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	1/4 (25%)
		Ion_trans	188..415	CDD:459842	48/248 (19%)
		DUF3399	471..535	CDD:463381	10/63 (16%)